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Tnnt3 Gene Detail
Summary
  • Symbol
    Tnnt3
  • Name
    troponin T3, skeletal, fast
  • Synonyms
    fTnT, skeletal muscle fast-twitch TnT
  • Feature Type
    protein coding gene
  • IDs
    MGI:109550
    NCBI Gene: 21957
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142052573-142069746 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109550
protein coding gene Chr7:142052530-142069746 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033259
protein coding gene Chr7:147755875-147774610 (+)
A/J MGP_AJ_G0033242
protein coding gene Chr7:143491456-143509884 (+)
AKR/J MGP_AKRJ_G0033174
protein coding gene Chr7:147519281-147536423 (+)
BALB/cJ MGP_BALBcJ_G0033243
protein coding gene Chr7:143263511-143280844 (+)
C3H/HeJ MGP_C3HHeJ_G0032958
protein coding gene Chr7:147278687-147295828 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033753
protein coding gene Chr7:153100347-153117498 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030726
protein coding gene Chr7:144700440-144717308 (+)
CAST/EiJ MGP_CASTEiJ_G0032281
protein coding gene Chr7:139588369-139605286 (+)
CBA/J MGP_CBAJ_G0032929
protein coding gene Chr7:158346342-158363517 (+)
DBA/2J MGP_DBA2J_G0033083
protein coding gene Chr7:141444409-141461570 (+)
FVB/NJ MGP_FVBNJ_G0033032
protein coding gene Chr7:141379486-141396655 (+)
LP/J MGP_LPJ_G0033176
protein coding gene Chr7:149266259-149283410 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033066
protein coding gene Chr7:158965329-158982490 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033772
protein coding gene Chr7:146467655-146484814 (+)
PWK/PhJ MGP_PWKPhJ_G0031989
protein coding gene Chr7:134772097-134789084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031835
protein coding gene Chr7:133267005-133283893 (+)
WSB/EiJ MGP_WSBEiJ_G0032393
protein coding gene Chr7:147445598-147462856 (+)



Homology
more
  • Human Ortholog
    TNNT3, troponin T3, fast skeletal type
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNNT3, troponin T3, fast skeletal type
  • Synonyms
    beta-TnTF, DA2B2, TNTF
  • Links
    NCBI Gene ID: 7140
    neXtProt AC: NX_P45378
    UniProt: P45378

  • Chr Location
    11p15.5; chr11:1919552-1938706 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human TNNT3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    4 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, decreased fetal weight, liver and kidney hemorrhage and thin diaphragm. Mice heterozygous for this allele exhibit growth retardation with mild skeleton defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061723 Ensembl Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
    transcript ENSMUST00000179658 Ensembl | MGI Sequence Detail 1079 Not Applicable  
    polypeptide ENSMUSP00000136278 Ensembl | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      Genomic 7
      cDNA 97
      Primer pair 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39549
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 36
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
    • Latest
      J:304923 Doll CF, et al., Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part. Sci Rep. 2021 Mar 23;11(1):6608

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory