About   Help   FAQ
Tnnt3
Gene Detail
 Symbol
Name
ID
Tnnt3
troponin T3, skeletal, fast
MGI:109550
Synonyms fTnT, skeletal muscle fast-twitch TnT
Feature Type protein coding gene
Genetic Map
Chromosome 7
87.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:142498836-142516009 bp, + strand
From VEGA annotation of GRCm38

  17174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31405  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tnnt3

Human
homologs
Human Homolog TNNT3, troponin T type 3 (skeletal, fast)
NCBI Gene ID 7140
neXtProt AC  NX_P45378
Human Synonyms  TNTF
Human Chr (Location)  11p15.5; chr11:1919562-1938706 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TNNT3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, decreased fetal weight, liver and kidney hemorrhage and thin diaphragm. Mice heterozygous for this allele exhibit growth retardation with mild skeleton defects.
 
Interactions
Tnnt3 interacts with 25 markers (Mir207, Mir212, Mir214, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ATP catabolic process, regulation of ATPase activity, ...
Component troponin complex
Function actin binding, calcium-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (155)    Tissues (47)    Images (31)
Theiler Stages: 15, 17, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 97
RT-PCR 58
cDNA source data(95)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) Genomic(7) cDNA(95) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018789 (Evidence)
Ensembl Gene ModelENSMUSG00000061723 (Evidence)
Entrez Gene21957 (Evidence)
UniGene389992
DFCITC1579167, TC1587307, TC1587754, TC1588163, TC1588411, TC1588984, TC1592944, TC1627951, TC1639960
DoTSDT.101387010, DT.102542534, DT.55100263, DT.94400177, DT.94400194, DT.97400372, DT.97400373
NIA Mouse Gene IndexU042875
Consensus CDS ProjectCCDS22031.1, CCDS52451.1, CCDS52452.1, CCDS52453.1, CCDS52454.1, CCDS52455.1, CCDS52456.1, CCDS52457.1
International Mouse Knockout Project StatusTnnt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018789 VEGA Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
transcript OTTMUST00000045212 VEGA | MGI Sequence Detail 1079 Not Applicable 
polypeptide OTTMUSP00000020326 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(288) RefSeq(130) UniProt(20)
Polymorphisms RFLP(1) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001978 Troponin
Protein Ontology PR:000016510 troponin T, fast skeletal muscle
References (Earliest) J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
(Latest) J:208283 Sancisi V, et al., Altered Tnnt3 characterizes selective weakness of fast fibers in mice overexpressing FSHD region gene 1 (FRG1). Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15;306(2):R124-37
All references(49)
Other
accession IDs
MGD-MRK-39549

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory