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Adam10
Gene Detail
Symbol

Name
ID
Adam10
a disintegrin and metallopeptidase domain 10
MGI:109548
Synonyms
1700031C13Rik, kuz, kuzbanian
Feature Type
protein coding gene
Genetic Map
Chromosome 9
39.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:70678997-70780229 bp, + strand
From VEGA annotation of GRCm38

  101233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ADAM 10 endopeptidase
Gene Tree: Adam10

Human
homologs
Human Homolog ADAM10, ADAM metallopeptidase domain 10
NCBI Gene ID 102
neXtProt AC  NX_O14672
Human Synonyms  AD10, AD18, CD156c, HsT18717, kuz, MADM, RAK
Human Chr (Location)  15q22; chr15:58595204-58749978 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADAM10
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted inactivation of this gene leads to embryonic lethality at E9.5. Embryos homozygous for a knock-out allele display decreased size and multiple abnormalities related to Notch signaling, including defects of the developing central nervous system, somites, and cardiovascular system.
 
Interactions
Adam10 interacts with 405 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process constitutive protein ectodomain proteolysis, in utero embryonic development, ...
Component cell, cell surface, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (183)    Tissues (55)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 137
Western blot 22
RT-PCR 1
cDNA source data(179)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(182) Genomic(1) cDNA(179) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033211 (Evidence)
Ensembl Gene ModelENSMUSG00000054693 (Evidence)
Entrez Gene11487 (Evidence)
UniGene3037
DFCITC1602066, TC1598451, TC1597292, TC1579683
DoTSDT.489991, DT.102557350
NIA Mouse Gene IndexU010708
EC3.4.24.81
Consensus CDS ProjectCCDS23323.1
International Mouse Knockout Project StatusAdam10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033211 VEGA Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
transcript OTTMUST00000083164 VEGA | MGI Sequence Detail 4593 Not Applicable 
polypeptide OTTMUSP00000044639 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR027053 Disintegrin and metalloproteinase domain-containing protein 10
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000001278 disintegrin and metalloproteinase domain-containing protein 10
References
(Earliest) J:45558 Yamazaki K, et al., Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9. Genomics. 1997 Dec 15;46(3):528-9
(Latest) J:213737 Pruessmeyer J, et al., Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space. Blood. 2014 Jun 26;123(26):4077-88
All references(99)
Other
accession IDs
MGD-MRK-39547, MGI:1914564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory