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Adam10 Gene Detail
Summary
  • Symbol
    Adam10
  • Name
    a disintegrin and metallopeptidase domain 10
  • Synonyms
    1700031C13Rik, kuz, kuzbanian
  • Feature Type
    protein coding gene
  • IDs
    MGI:109548
    NCBI Gene: 11487
  • Gene Overview
    MyGene.info: ADAM10
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:70678997-70780229 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      101233 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.53 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ADAM10, ADAM metallopeptidase domain 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAM10, ADAM metallopeptidase domain 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AD10, AD18, CD156c, CDw156, HsT18717, kuz, MADM, RAK
  • Links
    NCBI Gene ID: 102
    neXtProt AC: NX_O14672
    UniProt: O14672

  • Chr Location
    15q21.3; chr15:58595204-58749978 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human ADAM10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 7 alleles in 10 genetic backgrounds
    20 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to embryonic lethality at E9.5. Embryos homozygous for a knock-out allele display decreased size and multiple abnormalities related to Notch signaling, including defects of the developing central nervous system, somites, and cardiovascular system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    63
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    190
  • Tissues
    59
  • cDNA Data
    180
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033211 VEGA Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
    transcript OTTMUST00000083164 VEGA | MGI Sequence Detail 4593 Not Applicable  
    polypeptide OTTMUSP00000044639 VEGA | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      189 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 1
      cDNA 180
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-39547, MGI:1914564
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 21
      Gene Ontology 13
      Phenotypes 47
    • Earliest
      J:45558 Yamazaki K, et al., Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9. Genomics. 1997 Dec 15;46(3):528-9
    • Latest
      J:254707 Wichert R, et al., Mucus Detachment by Host Metalloprotease Meprin beta Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory