Adam10
Gene Detail

Symbol Name ID

Adam10 a disintegrin and metallopeptidase domain 10 MGI:109548

Synonyms

1700031C13Rik, kuz, kuzbanian

Feature Type

protein coding gene

Genetic Map

Chromosome 9

39.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:70678997-70780229 bp, + strand From VEGA annotation of GRCm38   101233 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ADAM 10 endopeptidase
Gene Tree: Adam10

Human homologs

Human Homolog		ADAM10, ADAM metallopeptidase domain 10
NCBI Gene ID		102
neXtProt AC		NX_O14672
Human Synonyms		AD10, AD18, CD156c, HsT18717, kuz, MADM, RAK
Human Chr (Location)		15q22; chr15:58595204-58749978 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human ADAM10

Alleles and phenotypes

All alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

Targeted inactivation of this gene leads to embryonic lethality at E9.5. Embryos homozygous for a knock-out allele display decreased size and multiple abnormalities related to Notch signaling, including defects of the developing central nervous system, somites, and cardiovascular system.

 

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	constitutive protein ectodomain proteolysis, in utero embryonic development, ...
Component	cell, cell surface, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (183)    Tissues (54)    Images (48)
Theiler Stages: 15, 16, 20, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	137
Western blot	22
RT-PCR	1

cDNA source data(179)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(182) Genomic(1) cDNA(179) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000033211 (Evidence)
Ensembl Gene Model	ENSMUSG00000054693 (Evidence)
Entrez Gene	11487 (Evidence)
UniGene	3037
DFCI	TC1579683, TC1597292, TC1598451, TC1602066
DoTS	DT.102557350, DT.489991
NIA Mouse Gene Index	U010708
EC	3.4.24.81
Consensus CDS Project	CCDS23323.1
International Mouse Knockout Project Status	Adam10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033211	VEGA Gene Model | MGI Sequence Detail	101233	C57BL/6J
transcript	OTTMUST00000083164	VEGA | MGI Sequence Detail	4593	Not Applicable
polypeptide	OTTMUSP00000044639	VEGA | MGI Sequence Detail	749	Not Applicable

All sequences(47) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs within 2kb(192 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR027053	Disintegrin and metalloproteinase domain-containing protein 10
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000001278	disintegrin and metalloproteinase domain-containing protein 10

References

(Earliest) J:45558 Yamazaki K, et al., Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9. Genomics. 1997 Dec 15;46(3):528-9
(Latest) J:207127 Folgosa L, et al., Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-alpha shedding. J Immunol. 2013 Dec 15;191(12):5951-8
All references(95)

Other accession IDs

MGD-MRK-39547, MGI:1914564