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Adam10 Gene Detail
Summary
  • Symbol
    Adam10
  • Name
    a disintegrin and metallopeptidase domain 10
  • Synonyms
    1700031C13Rik, kuz, kuzbanian
  • Feature Type
    protein coding gene
  • IDs
    MGI:109548
    NCBI Gene: 11487
  • Gene Overview
    MyGene.info: ADAM10
Location & Maps
more
  • Sequence Map
    Chr9:70678997-70780229 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      101233 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.53 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ADAM10, ADAM metallopeptidase domain 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAM10, ADAM metallopeptidase domain 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AD10, AD18, CD156c, CDw156, HsT18717, kuz, MADM, RAK
  • Links
    NCBI Gene ID: 102
    neXtProt AC: NX_O14672

  • Chr Location
    15q22; chr15:58595204-58749978 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    2 with human ADAM10 associations

Human Disease Mouse Models
       Alzheimer Disease 18; AD18   OMIM: 615590
Reticulate Acropigmentation of Kitamura; RAK   OMIM: 615537
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 7 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    9
  • Genomic Mutations
    1 involving Adam10
  • Incidental Mutations
    Mutagenetix , APF
Targeted inactivation of this gene leads to embryonic lethality at E9.5. Embryos homozygous for a knock-out allele display decreased size and multiple abnormalities related to Notch signaling, including defects of the developing central nervous system, somites, and cardiovascular system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    50
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    183
  • Tissues
    55
  • cDNA Data
    179
  • Literature Summary
    19
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033211 VEGA Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
transcript OTTMUST00000083164 VEGA | MGI Sequence Detail 4593 Not Applicable  
polypeptide OTTMUSP00000044639 VEGA | MGI Sequence Detail 749 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    189 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001278 disintegrin and metalloproteinase domain-containing protein 10
  • EC
    3.4.24.81
  • InterPro Domains
    IPR027053 Disintegrin and metalloproteinase domain-containing protein 10
    IPR001762 Disintegrin domain
    IPR024079 Metallopeptidase, catalytic domain
    IPR001590 Peptidase M12B, ADAM/reprolysin
    IPR002870 Peptidase M12B, propeptide
Molecular
Reagents
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  • All nucleic 182
    Genomic 1
    cDNA 179
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-39547, MGI:1914564
References
more
  • Summaries
    All 112
    Developmental Gene Expression 19
    Gene Ontology 11
    Phenotypes 39
  • Earliest
    J:45558 Yamazaki K, et al., Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9. Genomics. 1997 Dec 15;46(3):528-9
  • Latest
    J:230660 Kuhn PH, et al., Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife. 2016;5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory