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Sycp3
Gene Detail
 Symbol
Name
ID
Sycp3
synaptonemal complex protein 3
MGI:109542
Synonyms Cor1, Scp3
Feature Type protein coding gene
Genetic Map
Chromosome 10
43.94 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:88459569-88473236 bp, + strand
From VEGA annotation of GRCm38

  13668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sycp3

Human
homologs
Human Homolog SYCP3, synaptonemal complex protein 3
NCBI Gene ID 50511
neXtProt AC  NX_Q8IZU3
Human Synonyms  COR1, SCP3, SPGF4
Human Chr (Location)  12q; chr12:101728648-101739689 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SYCP3
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
 
Homozygous mutants are male infertile and female sub-fertile. Reduced litter size in females is due to achiasmatic oocytes, resulting in aneuploidy and embryonic death. Meiosis in males blocks at early prophase with lack of synaptonemal complexes.
 
Human Diseases Modeled Using Mouse Sycp3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sycp3 interacts with 81 markers (Mir7-1, Mir19a, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cell cycle, cell division, ...
Component chromosome, condensed chromosome, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (93 records)
Data Summary: Results (98)    Tissues (31)    Images (35)
Theiler Stages: 15, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 70
Western blot 6
RT-PCR 22
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(10) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023468 (Evidence)
Ensembl Gene ModelENSMUSG00000020059 (Evidence)
Entrez Gene20962 (Evidence)
NIA Mouse Gene IndexU011862
Consensus CDS ProjectCCDS24111.1
International Mouse Knockout Project StatusSycp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023468 VEGA Gene Model | MGI Sequence Detail 13668 C57BL/6J ±  kb
transcript OTTMUST00000057079 VEGA | MGI Sequence Detail 1139 Not Applicable 
polypeptide OTTMUSP00000027498 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006888 Cor1/Xlr/Xmr family
Protein Ontology PR:000015865 synaptonemal complex protein 3
References (Earliest) J:39612 Klink A, et al., The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10. Mamm Genome. 1997 May;8(5):376-7
(Latest) J:208416 Holt JE, et al., The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development. 2014 Mar;141(6):1354-65
All references(166)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory