Sycp3
Gene Detail

Symbol Name ID

Sycp3 synaptonemal complex protein 3 MGI:109542

Synonyms

Cor1, Scp3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

43.94 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:88459569-88473236 bp, + strand From VEGA annotation of GRCm38   13668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7964  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sycp3

Human homologs

Human Homolog		SYCP3, synaptonemal complex protein 3
NCBI Gene ID		50511
neXtProt AC		NX_Q8IZU3
Human Synonyms		COR1, SCP3, SPGF4
Human Chr (Location)		12q; chr12:102122426-102133250 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SYCP3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutants are male infertile and female sub-fertile. Reduced litter size in females is due to achiasmatic oocytes, resulting in aneuploidy and embryonic death. Meiosis in males blocks at early prophase with lack of synaptonemal complexes.

 
Human Diseases Modeled Using Mouse Sycp3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	achiasmate meiosis I, cell cycle, ...
Component	chromosome, condensed chromosome, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (82 records)
Data Summary: Results (93)    Tissues (29)    Images (30)
Theiler Stages: 15, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	65
Western blot	6
RT-PCR	22

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(10) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023468 (Evidence)
Ensembl Gene Model	ENSMUSG00000020059 (Evidence)
Entrez Gene	20962 (Evidence)
NIA Mouse Gene Index	U011862
Consensus CDS Project	CCDS24111.1
International Mouse Knockout Project Status	Sycp3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023468	VEGA Gene Model | MGI Sequence Detail	13668	C57BL/6J
transcript	OTTMUST00000057079	VEGA | MGI Sequence Detail	1139	Not Applicable
polypeptide	OTTMUSP00000027498	VEGA | MGI Sequence Detail	254	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006888	Cor1/Xlr/Xmr family
Protein Ontology	PR:000015865	synaptonemal complex protein 3

References

(Earliest) J:39612 Klink A, et al., The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10. Mamm Genome. 1997 May;8(5):376-7
(Latest) J:194075 Guenatri M, et al., Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development. 2013 Feb 1;140(3):562-72
All references(150)

Other accession IDs

MGD-MRK-39541