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Sycp3 Gene Detail
Summary
  • Symbol
    Sycp3
  • Name
    synaptonemal complex protein 3
  • Synonyms
    Cor1, Scp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109542
    NCBI Gene: 20962
  • Gene Overview
    MyGene.info: SYCP3
Location & Maps
more
  • Sequence Map
    Chr10:88459569-88473236 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13668 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SYCP3, synaptonemal complex protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYCP3, synaptonemal complex protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COR1, RPRGL4, SCP3, SPGF4
  • Links
    NCBI Gene ID: 50511
    neXtProt AC: NX_Q8IZU3

  • Chr Location
    12q; chr12:101728648-101739513 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7964
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SYCP3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sycp3 mouse models; 1 with human SYCP3 associations

Human Disease Mouse Models
       Spermatogenic Failure 4; SPGF4   OMIM: 270960 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    7
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Sycp3
  • Incidental Mutations
Homozygous mutants are male infertile and female sub-fertile. Reduced litter size in females is due to achiasmatic oocytes, resulting in aneuploidy and embryonic death. Meiosis in males blocks at early prophase with lack of synaptonemal complexes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023468 VEGA Gene Model | MGI Sequence Detail 13668 C57BL/6J ±  kb
transcript OTTMUST00000057079 VEGA | MGI Sequence Detail 1139 Not Applicable  
polypeptide OTTMUSP00000027498 VEGA | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    152 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015865 synaptonemal complex protein 3
  • InterPro Domains
    IPR006888 XLR/SYCP3/FAM9 domain
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 10
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-39541
References
more
  • Summaries
    All 194
    Developmental Gene Expression 113
    Diseases 1
    Gene Ontology 43
    Phenotypes 33
  • Earliest
    J:39612 Klink A, et al., The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10. Mamm Genome. 1997 May;8(5):376-7
  • Latest
    J:229539 Heeren AM, et al., On the development of extragonadal and gonadal human germ cells. Biol Open. 2016;5(2):185-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory