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Sycp3
Gene Detail
Symbol

Name
ID
Sycp3
synaptonemal complex protein 3
MGI:109542
Synonyms
Cor1, Scp3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
43.94 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:88459569-88473236 bp, + strand
From VEGA annotation of GRCm38

  13668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYCP3
Gene Tree: Sycp3

Human
homologs
SYCP3, synaptonemal complex protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 50511
neXtProt AC: NX_Q8IZU3

Human Synonyms: COR1, SCP3, SPGF4

Human Chr (Location): 12q; chr12:101728648-101739513 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SYCP3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from CvDC )
 
Homozygous mutants are male infertile and female sub-fertile. Reduced litter size in females is due to achiasmatic oocytes, resulting in aneuploidy and embryonic death. Meiosis in males blocks at early prophase with lack of synaptonemal complexes.
 
Human Diseases Modeled in Mice Using Sycp3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sycp3 interacts with 81 markers (Mir7-1, Mir19a, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cell cycle, cell division, ...
Component chromosome, condensed chromosome, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (103 records)
Data Summary: Results (108)    Tissues (33)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 75
Western blot 6
RT-PCR 27
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SYCP3 ; Xenbase sycp3 ; ZFIN sycp3    NEW 
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(10) Primer pair(5)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023468 (Evidence)
Ensembl Gene Model ENSMUSG00000020059 (Evidence)
Entrez Gene 20962 (Evidence)
NIA Mouse Gene Index U011862
Consensus CDS Project CCDS24111.1
International Mouse Phenotyping Consortium Status Sycp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023468 VEGA Gene Model | MGI Sequence Detail 13668 C57BL/6J ±  kb
transcript OTTMUST00000057079 VEGA | MGI Sequence Detail 1139 Not Applicable 
polypeptide OTTMUSP00000027498 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006888 Cor1/Xlr/Xmr family
Protein Ontology PR:000015865 synaptonemal complex protein 3
References
(Earliest) J:39612 Klink A, et al., The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10. Mamm Genome. 1997 May;8(5):376-7
(Latest) J:217603 Vanhoutteghem A, et al., The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014 Nov;141(22):4298-310
All references(183)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory