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Tfpi Gene Detail
Summary
  • Symbol
    Tfpi
  • Name
    tissue factor pathway inhibitor
  • Synonyms
    A630013F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095418
    NCBI Gene: 21788
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:84432855-84476775 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43921 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TFPI, tissue factor pathway inhibitor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TFPI, tissue factor pathway inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPI, LACI, TFI, TFPI1
  • Links
    NCBI Gene ID: 7035
    neXtProt AC: NX_P10646
    UniProt: P10646

  • Chr Location
    2q32.1; chr2:187464230-187554498 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant embryos die showing hemorrhages of the yolk sac, central nervous system, and tail.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000013407 VEGA Gene Model | MGI Sequence Detail 43921 C57BL/6J ±  kb
    transcript OTTMUST00000032382 VEGA | MGI Sequence Detail 2027 Not Applicable  
    polypeptide OTTMUSP00000014384 VEGA | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      320 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000016279 tissue factor pathway inhibitor
    • InterPro Domains
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
      IPR029864 Tissue factor pathway inhibitor 1
      IPR008296 Tissue factor pathway inhibitor-like
    Molecular
    Reagents
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    • All nucleic 103
      Genomic 1
      cDNA 100
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2139389, MGI:2443242
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 26
    • Earliest
      J:41945 Huang ZF, et al., Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997 Aug 1;90(3):944-51
    • Latest
      J:244506 Westrick RJ, et al., Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci. Proc Natl Acad Sci U S A. 2017 Sep 05;114(36):9659-9664

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory