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Tfpi
Gene Detail
 Symbol
Name
ID
Tfpi
tissue factor pathway inhibitor
MGI:1095418
Synonyms A630013F22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:84432855-84476775 bp, - strand
From VEGA annotation of GRCm38

  43921 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4579  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: tissue factor pathway inhibitor
Gene Tree: Tfpi

Human
homologs
Human Homolog TFPI, tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
NCBI Gene ID 7035
neXtProt AC  NX_P10646
Human Synonyms  EPI, LACI, TFI, TFPI1
Human Chr (Location)  2q32; chr2:187464230-187554492 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(52) Targeted(5)
Genomic Mutations involving Tfpi (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos die showing hemorrhages of the yolk sac, central nervous system, and tail.
 
Interactions
Tfpi interacts with 326 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular space
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (166)    Tissues (55)    Images (34)
Theiler Stages: 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 117
Northern blot 32
Western blot 5
RT-PCR 12
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) Genomic(1) cDNA(100) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000013407 (Evidence)
Ensembl Gene ModelENSMUSG00000027082 (Evidence)
Entrez Gene21788 (Evidence)
UniGene124316
DFCITC1577595, TC1584389, TC1597904, TC1626400
DoTSDT.101304130, DT.101735916, DT.91388802, DT.97362307
NIA Mouse Gene IndexU022807
Consensus CDS ProjectCCDS16185.1, CCDS50620.1
International Mouse Knockout Project StatusTfpi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013407 VEGA Gene Model | MGI Sequence Detail 43921 C57BL/6J ±  kb
transcript OTTMUST00000032382 VEGA | MGI Sequence Detail 2027 Not Applicable 
polypeptide OTTMUSP00000014384 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(18) UniProt(6)
Polymorphisms SNPs within 2kb(322 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
InterPro IPR008296 Proteinase inhibitor I2, tissue factor pathway inhibitor
Protein Ontology PR:000016279 tissue factor pathway inhibitor
References (Earliest) J:41945 Huang ZF, et al., Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997 Aug 1;90(3):944-51
(Latest) J:194708 Holroyd EW, et al., Tissue factor pathway inhibitor blocks angiogenesis via its carboxyl terminus. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):704-11
All references(50)
Other
accession IDs
MGI:2139389, MGI:2443242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory