Cdh17
Gene Detail

Symbol Name ID

Cdh17 cadherin 17 MGI:1095414

Synonyms

BILL-cadherin, HPT-1, LI-cadherin

Feature Type

protein coding gene

Genetic Map

Chromosome 4

5.35 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:11758147-11817895 bp, + strand From VEGA annotation of GRCm38   59749 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cdh17

Human homologs

Human Homolog		CDH17, cadherin 17, LI cadherin (liver-intestine)
NCBI Gene ID		1015
neXtProt AC		NX_Q12864
Human Synonyms		CDH16, HPT1, HPT-1
Human Chr (Location)		8q22.1; chr8:95139394-95229531 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygous mutant mice exhibit impaired B lymphocyte development and impaired IgG1 and IgG3 antibody response to T-independent antigen.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	calcium-dependent cell-cell adhesion, cell adhesion, ...
Component	basolateral plasma membrane, integral to membrane, ...
Function	calcium ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (82)    Tissues (60)    Images (27)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	44
Northern blot	15
Western blot	2
RT-PCR	6

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000004521 (Evidence)
Ensembl Gene Model	ENSMUSG00000028217 (Evidence)
Entrez Gene	12557 (Evidence)
UniGene	33402
DFCI	TC1580824, TC1607544
DoTS	DT.101715332, DT.102532356, DT.487852
NIA Mouse Gene Index	U004072
Consensus CDS Project	CCDS17972.1
International Mouse Knockout Project Status	Cdh17

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004521	VEGA Gene Model | MGI Sequence Detail	59749	C57BL/6J
transcript	OTTMUST00000010244	VEGA | MGI Sequence Detail	3462	Not Applicable
polypeptide	OTTMUSP00000004872	VEGA | MGI Sequence Detail	827	Not Applicable

All sequences(32) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(202 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR015919	Cadherin-like
Protein Ontology	PR:000005235	cadherin-17

References

(Earliest) J:33453 Dantzig AH, et al., Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science. 1994 Apr 15;264(5157):430-3
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)