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Cdh17 Gene Detail
Summary
  • Symbol
    Cdh17
  • Name
    cadherin 17
  • Synonyms
    BILL-cadherin, HPT-1, LI-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095414
    NCBI Gene: 12557
  • Gene Overview
    MyGene.info: CDH17
Location & Maps
more
  • Sequence Map
    Chr4:11758147-11817895 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59749 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 5.35 cM, cytoband A2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CDH17, cadherin 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDH17, cadherin 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDH16, HPT1, HPT-1
  • Links
    NCBI Gene ID: 1015
    neXtProt AC: NX_Q12864

  • Chr Location
    8q22.1; chr8:94127162-94217303 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56859
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CDH17
  • Gene Tree
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cdh17
  • Incidental Mutations
Homozygous mutant mice exhibit impaired B lymphocyte development and impaired IgG1 and IgG3 antibody response to T-independent antigen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004521 VEGA Gene Model | MGI Sequence Detail 59749 C57BL/6J ±  kb
transcript OTTMUST00000010244 VEGA | MGI Sequence Detail 3462 Not Applicable  
polypeptide OTTMUSP00000004872 VEGA | MGI Sequence Detail 827 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    229 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:33453 Dantzig AH, et al., Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science. 1994 Apr 15;264(5157):430-3
  • Latest
    J:225656 Funakoshi S, et al., BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. PLoS One. 2015;10(1):e0117566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory