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Tuba4a Gene Detail
Summary
  • Symbol
    Tuba4a
  • Name
    tubulin, alpha 4A
  • Synonyms
    M[a]4, Tuba4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095410
    NCBI Gene: 22145
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75190872-75196509 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.63 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095410
protein coding gene Chr1:75190872-75197905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016179
protein coding gene Chr1:75778358-75783995 (-)
A/J MGP_AJ_G0016162
protein coding gene Chr1:73136948-73142585 (-)
AKR/J MGP_AKRJ_G0016119
protein coding gene Chr1:75166118-75171755 (-)
BALB/cJ MGP_BALBcJ_G0016117
protein coding gene Chr1:73197913-73203550 (-)
C3H/HeJ MGP_C3HHeJ_G0015948
protein coding gene Chr1:75499331-75504968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016570
protein coding gene Chr1:78727438-78733075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014291
protein coding gene Chr1:68696921-68702572 (-)
CAST/EiJ MGP_CASTEiJ_G0015532
protein coding gene Chr1:74837232-74842870 (-)
CBA/J MGP_CBAJ_G0015921
protein coding gene Chr1:81287826-81293463 (-)
DBA/2J MGP_DBA2J_G0016022
protein coding gene Chr1:72455161-72460798 (-)
FVB/NJ MGP_FVBNJ_G0016025
protein coding gene Chr1:71654103-71659740 (-)
LP/J MGP_LPJ_G0016094
protein coding gene Chr1:76902631-76908268 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016045
protein coding gene Chr1:84645885-84651522 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016617
protein coding gene Chr1:75237130-75242767 (-)
PWK/PhJ MGP_PWKPhJ_G0015319
protein coding gene Chr1:71925452-71931099 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015097
protein coding gene Chr1:74595225-74600859 (-)
WSB/EiJ MGP_WSBEiJ_G0015594
protein coding gene Chr1:75049046-75054683 (-)



Homology
more
  • Human Ortholog
    TUBA4A, tubulin alpha 4a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA4A, tubulin alpha 4a
  • Synonyms
    ALS22, H2-ALPHA, TUBA1
  • Links
    NCBI Gene ID: 7277
    neXtProt AC: NX_P68366
    UniProt: P68366

  • Chr Location
    2q35; chr2:219249710-219277902 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TUBA4A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    7
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Tuba4a
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous knockout results in a low platelet count and spherical platelets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026202 Ensembl Gene Model | MGI Sequence Detail 5638 C57BL/6J ±  kb
transcript ENSMUST00000079464 Ensembl | MGI Sequence Detail 2083 Not Applicable  
polypeptide ENSMUSP00000078429 Ensembl | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 65
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory