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Tuba4a
Gene Detail
 Symbol
Name
ID
Tuba4a
tubulin, alpha 4A
MGI:1095410
Synonyms M[a]4, Tuba4
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.63 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:75214228-75219865 bp, - strand
From VEGA annotation of GRCm38

  5638 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tuba4a

Human
homologs
Human Homolog TUBA4A, tubulin, alpha 4a
NCBI Gene ID 7277
neXtProt AC  NX_P68366
Human Synonyms  H2-ALPHA, TUBA1
Human Chr (Location)  2q35; chr2:219249711-219254608 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Spontaneous(1) Targeted(1)
Genomic Mutations involving Tuba4a (1)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(1)   
Interactions
Tuba4a interacts with 69 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process GTP catabolic process, microtubule-based process, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (47)    Tissues (11)    Images (5)
Theiler Stages: 2, 3, 24, 27, 28
Assay TypeResults
RNA in situ 11
RT-PCR 36
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000048543 (Evidence)
Ensembl Gene ModelENSMUSG00000026202 (Evidence)
Entrez Gene22145 (Evidence)
NIA Mouse Gene IndexU021496, U324788
Consensus CDS ProjectCCDS35623.1
International Mouse Knockout Project StatusTuba4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048543 VEGA Gene Model | MGI Sequence Detail 5638 C57BL/6J ±  kb
transcript OTTMUST00000124384 VEGA | MGI Sequence Detail 2083 Not Applicable 
polypeptide OTTMUSP00000067687 VEGA | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002452 Alpha tubulin
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016812 tubulin alpha-4A chain
References (Earliest) J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
(Latest) J:184585 Yamamoto M, et al., The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biol Open. 2012;1(5):458-466
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory