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Tuba4a Gene Detail
Summary
  • Symbol
    Tuba4a
  • Name
    tubulin, alpha 4A
  • Synonyms
    M[a]4, Tuba4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095410
    NCBI Gene: 22145
  • Gene Overview
    MyGene.info: TUBA4A
Location & Maps
more
  • Sequence Map
    Chr1:75214228-75219865 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5638 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.63 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TUBA4A, tubulin alpha 4a
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TUBA4A, tubulin alpha 4a
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS22, H2-ALPHA, TUBA1
  • Links
    NCBI Gene ID: 7277
    neXtProt AC: NX_P68366

  • Chr Location
    2q35; chr2:219249711-219254608 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TUBA4A associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 22 with or without Frontotemporal Dementia;   OMIM: 616208
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Tuba4a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048543 VEGA Gene Model | MGI Sequence Detail 5638 C57BL/6J ±  kb
transcript OTTMUST00000124384 VEGA | MGI Sequence Detail 2083 Not Applicable  
polypeptide OTTMUSP00000067687 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
  • Latest
    J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory