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Tuba1c Gene Detail
Summary
  • Symbol
    Tuba1c
  • Name
    tubulin, alpha 1C
  • Synonyms
    M[a]6, Tuba6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095409
    NCBI Gene: 22146
  • Gene Overview
    MyGene.info: TUBA1C
Location & Maps
more
  • Sequence Map
    Chr15:99029891-99038105 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8215 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 55.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TUBA1C, tubulin alpha 1c
  • Vertebrate Orthologs
    12
  • Human Ortholog
    TUBA1C, tubulin alpha 1c
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bcm948, TUBA6
  • Links
    NCBI Gene ID: 84790
    neXtProt AC: NX_Q9BQE3

  • Chr Location
    12q13.12; chr12:49227926-49273338 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69045
    1 human;1 mouse;2 rat;1 chimpanzee;2 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TUBA1C
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotype references
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Tuba1c
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22146 NCBI Gene Model | MGI Sequence Detail 8215 C57BL/6J ±  kb
transcript NM_009448 RefSeq | MGI Sequence Detail 1977 C57BL/6  
polypeptide P68373 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 279
    cDNA 279

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 24
  • Earliest
    J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
  • Latest
    J:145723 Zhao M, et al., Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol. 2009 Mar;29(5):1291-305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory