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Mfng Gene Detail
Summary
  • Symbol
    Mfng
  • Name
    MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Synonyms
    manic fringe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095404
    NCBI Gene: 17305
  • Gene Overview
    MyGene.info: MFNG
Location & Maps
more
  • Sequence Map
    Chr15:78755882-78773475 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17594 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.69 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4242
    neXtProt AC: NX_O00587

  • Chr Location
    22q12; chr22:37469063-37486440 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    8
  • Genomic Mutations
    3 involving Mfng
  • Incidental Mutations
Mice homozygous for a null mutation exhibit normal pancreatic development, morphology and physiology. Mice homozygous for a different knock-out allele exhibit altered lymphocyte numbers, abnormal circulating factors II, VII, IX and XI, and decreased prothrombin and partial thromboplastin time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021012 VEGA Gene Model | MGI Sequence Detail 17594 C57BL/6J ±  kb
transcript OTTMUST00000049672 VEGA | MGI Sequence Detail 1865 Not Applicable  
polypeptide OTTMUSP00000023053 VEGA | MGI Sequence Detail 321 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    100 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 47
    Genomic 2
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2146229
References
more
  • Summaries
    All 60
    Developmental Gene Expression 29
    Diseases 1
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
  • Latest
    J:221116 Zhang S, et al., Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction. Cancer Res. 2015 May 15;75(10):1936-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory