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Zfpm1 Gene Detail
Summary
  • Symbol
    Zfpm1
  • Name
    zinc finger protein, multitype 1
  • Synonyms
    Fog1, Friend of GATA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095400
    NCBI Gene: 22761
  • Gene Overview
    MyGene.info: ZFPM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:122282141-122337251 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55111 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.86 cM, cytoband E1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZFPM1, zinc finger protein, FOG family member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ZFPM1, zinc finger protein, FOG family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A
  • Links
    NCBI Gene ID: 161882
    neXtProt AC: NX_Q8IX07
    UniProt: Q8IX07

  • Chr Location
    16q24.2; chr16:88451782-88535166 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 7 alleles in 7 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants have poorly vascularized yolk sacs and small, pale livers. Mutants die between embryonic days 10.5 and 12.5 with severe anemia associated with a block in megakaryocyte development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042121 VEGA Gene Model | MGI Sequence Detail 55111 C57BL/6J ±  kb
    transcript OTTMUST00000110497 VEGA | MGI Sequence Detail 3390 Not Applicable  
    polypeptide OTTMUSP00000061643 VEGA | MGI Sequence Detail 995 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      589 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 7
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 19
      Gene Ontology 21
      Phenotypes 15
    • Earliest
      J:13573 LaRosa GJ, et al., Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox. Mol Cell Biol. 1988 Sep;8(9):3906-17
    • Latest
      J:239986 Lahti L, et al., Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei. Development. 2016 Feb 01;143(3):516-29

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory