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Cort Gene Detail
Summary
  • Symbol
    Cort
  • Name
    cortistatin
  • Synonyms
    CST, PCST
  • Feature Type
    protein coding gene
  • IDs
    MGI:109538
    NCBI Gene: 12854
  • Gene Overview
    MyGene.info: CORT
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149125034-149126763 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109538
protein coding gene Chr4:149125034-149126763 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029134
protein coding gene Chr4:152939894-152941618 (-)
A/J MGP_AJ_G0029099
protein coding gene Chr4:146565916-146567649 (-)
AKR/J MGP_AKRJ_G0029047
protein coding gene Chr4:150583006-150584730 (-)
BALB/cJ MGP_BALBcJ_G0029115
protein coding gene Chr4:147075172-147076905 (-)
C3H/HeJ MGP_C3HHeJ_G0028836
protein coding gene Chr4:151141311-151143035 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029564
protein coding gene Chr4:158460225-158461954 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026810
protein coding gene Chr4:138993853-138995583 (-)
CAST/EiJ MGP_CASTEiJ_G0028249
protein coding gene Chr4:148357181-148359323 (-)
CBA/J MGP_CBAJ_G0028798
protein coding gene Chr4:163120594-163122318 (-)
DBA/2J MGP_DBA2J_G0028947
protein coding gene Chr4:146683607-146685331 (-)
FVB/NJ MGP_FVBNJ_G0028911
protein coding gene Chr4:145784463-145786192 (-)
LP/J MGP_LPJ_G0029037
protein coding gene Chr4:152879060-152880784 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028938
protein coding gene Chr4:166359902-166361626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029596
protein coding gene Chr4:151076305-151078036 (-)
PWK/PhJ MGP_PWKPhJ_G0027969
protein coding gene Chr4:142677035-142678759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027803
protein coding gene Chr4:145309852-145311701 (-)
WSB/EiJ MGP_WSBEiJ_G0028329
protein coding gene Chr4:151232524-151234255 (-)



Homology
more
  • Human Ortholog
    CORT, cortistatin
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CORT, cortistatin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CST-14, CST-17, CST-29
  • Links
    NCBI Gene ID: 1325
    neXtProt AC: NX_O00230
    UniProt: O00230

  • Chr Location
    1p36.22; chr1:10449719-10452003 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased circulating growth hormone and adrenocorticotropin, decreased serum prolactin, and insulin resistance and increased serum glucose level in male mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12854 NCBI Gene Model | MGI Sequence Detail 1730 C57BL/6J ±  kb
    transcript NM_007745 RefSeq | MGI Sequence Detail 690 C57BL/6  
    polypeptide P56469 UniProt | EBI | MGI Sequence Detail 109 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39537
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:41516 de Lecea L, et al., Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. Genomics. 1997 Jun 15;42(3):499-506
    • Latest
      J:247473 Martersteck EM, et al., Diverse Central Projection Patterns of Retinal Ganglion Cells. Cell Rep. 2017 Feb 21;18(8):2058-2072

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory