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Itih4 Gene Detail
Summary
  • Symbol
    Itih4
  • Name
    inter alpha-trypsin inhibitor, heavy chain 4
  • Synonyms
    Itih-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109536
    NCBI Gene: 16427
  • Gene Overview
    MyGene.info: ITIH4
Location & Maps
more
  • Sequence Map
    Chr14:30886476-30901981 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15506 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.09 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ITIH4, inter-alpha-trypsin inhibitor heavy chain family member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITIH4, inter-alpha-trypsin inhibitor heavy chain family member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK120, PK-120
  • Links
    NCBI Gene ID: 3700
    neXtProt AC: NX_Q14624

  • Chr Location
    3p21.1; chr3:52812990-52830701 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ITIH4 associations

Human Disease Mouse Models
       Hypercholesterolemia, Familial   OMIM: 143890
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Surprisingly, IL-6/STAT3 signaling is significantly suppressed in mutant liver tissues but hepatocytes remain well differentiated.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026366 VEGA Gene Model | MGI Sequence Detail 15506 C57BL/6J ±  kb
transcript OTTMUST00000065206 VEGA | MGI Sequence Detail 3159 Not Applicable  
polypeptide OTTMUSP00000032460 VEGA | MGI Sequence Detail 942 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    173 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009149 inter-alpha-trypsin inhibitor heavy chain H4
  • InterPro Domains
    IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
    IPR013694 VIT domain
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 128
    cDNA 126
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39535
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory