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Itih4
Gene Detail
 Symbol
Name
ID
Itih4
inter alpha-trypsin inhibitor, heavy chain 4
MGI:109536
Synonyms Itih-4
Feature Type protein coding gene
Genetic Map
Chromosome 14
19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:30886476-30901981 bp, + strand
From VEGA annotation of GRCm38

  15506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: inter-alpha-trypsin inhibitor complex component II
Gene Tree: Itih4

Human
homologs
Human Homolog ITIH4, inter-alpha-trypsin inhibitor heavy chain family, member 4
NCBI Gene ID 3700
neXtProt AC  NX_Q14624
Human Synonyms  GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK120, PK-120
Human Chr (Location)  3p21.1; chr3:52812990-52830701 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITIH4
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Surprisingly, IL-6/STAT3 signaling is significantly suppressed in mutant liver tissues but hepatocytes remain well differentiated.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process acute-phase response, hyaluronan metabolic process, ...
Component blood microparticle, cytoplasm, ...
Function peptidase inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (28)    Tissues (22)    Images (1)
Theiler Stages: 17, 19, 20, 22, 28
Assay TypeResults
Northern blot 8
RT-PCR 20
cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(128) cDNA(126) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026366 (Evidence)
Ensembl Gene ModelENSMUSG00000021922 (Evidence)
Entrez Gene16427 (Evidence)
UniGene34819
DFCITC1577521, TC1661823
DoTSDT.101739712, DT.94307176
NIA Mouse Gene IndexU015452
Consensus CDS ProjectCCDS26901.1, CCDS49433.1
International Mouse Knockout Project StatusItih4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026366 VEGA Gene Model | MGI Sequence Detail 15506 C57BL/6J ±  kb
transcript OTTMUST00000065206 VEGA | MGI Sequence Detail 3159 Not Applicable 
polypeptide OTTMUSP00000032460 VEGA | MGI Sequence Detail 942 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(173 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
InterPro IPR013694 VIT domain
InterPro IPR002035 von Willebrand factor, type A
References (Earliest) J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)
Other
accession IDs
MGD-MRK-39535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory