Itih4
Gene Detail

Symbol Name ID

Itih4 inter alpha-trypsin inhibitor, heavy chain 4 MGI:109536

Synonyms

Itih-4

Feature Type

protein coding gene

Genetic Map

Chromosome 14

19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:30886476-30901981 bp, + strand From VEGA annotation of GRCm38   15506 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: inter-alpha-trypsin inhibitor complex component II
Gene Tree: Itih4

Human homologs

Human Homolog		ITIH4, inter-alpha-trypsin inhibitor heavy chain family, member 4
NCBI Gene ID		3700
neXtProt AC		NX_Q14624
Human Synonyms		GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK120, PK-120
Human Chr (Location)		3p21.1; chr3:52847006-52864717 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITIH4

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Surprisingly, IL-6/STAT3 signaling is significantly suppressed in mutant liver tissues but hepatocytes remain well differentiated.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	acute-phase response, hyaluronan metabolic process, ...
Component	cytoplasm, extracellular region, ...
Function	peptidase inhibitor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (28)    Tissues (22)    Images (1)
Theiler Stages: 17, 19, 20, 22, 28

Assay Type	Results
Northern blot	8
RT-PCR	20

cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(128) cDNA(126) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026366 (Evidence)
Ensembl Gene Model	ENSMUSG00000021922 (Evidence)
Entrez Gene	16427 (Evidence)
UniGene	34819
DFCI	TC1577521, TC1661823
DoTS	DT.101739712, DT.94307176
NIA Mouse Gene Index	U015452
Consensus CDS Project	CCDS26901.1, CCDS49433.1
International Mouse Knockout Project Status	Itih4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026366	VEGA Gene Model | MGI Sequence Detail	15506	C57BL/6J
transcript	OTTMUST00000065206	VEGA | MGI Sequence Detail	3159	Not Applicable
polypeptide	OTTMUSP00000032460	VEGA | MGI Sequence Detail	942	Not Applicable

All sequences(44) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(116 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010600	Inter-alpha-trypsin inhibitor heavy chain, C-terminal
InterPro	IPR013694	VIT domain
InterPro	IPR002035	von Willebrand factor, type A

References

(Earliest) J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Other accession IDs

MGD-MRK-39535