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Itih4 Gene Detail
Summary
  • Symbol
    Itih4
  • Name
    inter alpha-trypsin inhibitor, heavy chain 4
  • Synonyms
    Itih-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109536
    NCBI Gene: 16427
  • Gene Overview
    MyGene.info: ITIH4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30886476-30901986 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109536
protein coding gene Chr14:30886476-30902353 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021110
protein coding gene Chr14:24034003-24052760 (+)
A/J MGP_AJ_G0021058
protein coding gene Chr14:23139800-23155157 (+)
AKR/J MGP_AKRJ_G0021035
protein coding gene Chr14:24250599-24268382 (+)
BALB/cJ MGP_BALBcJ_G0021062
protein coding gene Chr14:23239289-23255713 (+)
C3H/HeJ MGP_C3HHeJ_G0020845
protein coding gene Chr14:24110710-24126037 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021494
protein coding gene Chr14:24999052-25017913 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019057
protein coding gene Chr14:23196901-23215370 (+)
CAST/EiJ MGP_CASTEiJ_G0020370
protein coding gene Chr14:23864924-23884618 (+)
CBA/J MGP_CBAJ_G0020812
protein coding gene Chr14:25948968-25969607 (+)
DBA/2J MGP_DBA2J_G0020934
protein coding gene Chr14:23164470-23180662 (+)
FVB/NJ MGP_FVBNJ_G0020918
protein coding gene Chr14:23121355-23137538 (+)
LP/J MGP_LPJ_G0021003
protein coding gene Chr14:24362583-24382280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020944
protein coding gene Chr14:25225362-25240675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021527
protein coding gene Chr14:24001889-24018657 (+)
PWK/PhJ MGP_PWKPhJ_G0020118
protein coding gene Chr14:22612769-22628756 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019942
protein coding gene Chr14:23587275-23604662 (+)
WSB/EiJ MGP_WSBEiJ_G0020425
protein coding gene Chr14:24063649-24082612 (+)



Homology
more
  • Human Ortholog
    ITIH4, inter-alpha-trypsin inhibitor heavy chain family member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITIH4, inter-alpha-trypsin inhibitor heavy chain family member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK120, PK-120
  • Links
    NCBI Gene ID: 3700
    neXtProt AC: NX_Q14624
    UniProt: Q14624

  • Chr Location
    3p21.1; chr3:52812990-52830701 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ITIH4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Surprisingly, IL-6/STAT3 signaling is significantly suppressed in mutant liver tissues but hepatocytes remain well differentiated.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16427 NCBI Gene Model | MGI Sequence Detail 15511 C57BL/6J ±  kb
transcript NM_018746 RefSeq | MGI Sequence Detail 3164 C57BL/6  
polypeptide A6X935 UniProt | EBI | MGI Sequence Detail 942 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
    IPR013694 VIT domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 129
    cDNA 127
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39535
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory