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Abcb7
Gene Detail
Symbol

Name
ID
Abcb7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
MGI:109533
Synonyms
Abc7
Feature Type
protein coding gene
Genetic Map
Chromosome X
46.58 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:104280657-104413856 bp, - strand
From VEGA annotation of GRCm38

  133200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCB7
Protein SuperFamily: ATP-binding cassette sub-family B member 7, mitochondrial precurso
Gene Tree: Abcb7

Human
homologs
ABCB7, ATP-binding cassette, sub-family B (MDR/TAP), member 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 22
neXtProt AC: NX_O75027

Human Synonyms: ABC7, ASAT, Atm1p, EST140535

Human Chr (Location): Xq13.3; chrX:75053172-75156340 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ABCB7

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Hemizygous male and heterozygous female mice carrying a maternally inherited null allele display prenatal lethality.
 
Interactions
Abcb7 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (157)    Tissues (143)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
Northern blot 21
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abcb7 ; ZFIN abcb7    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018115 (Evidence)
Ensembl Gene Model ENSMUSG00000031333 (Evidence)
Entrez Gene 11306 (Evidence)
DFCI TC1629218, TC1597695
DoTS DT.101350064, DT.111021629, DT.481749, DT.111021630, DT.91421222, DT.99850195
NIA Mouse Gene Index U039608
Consensus CDS Project CCDS53167.1
International Mouse Phenotyping Consortium Status Abcb7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018115 VEGA Gene Model | MGI Sequence Detail 133200 C57BL/6J ±  kb
transcript OTTMUST00000043710 VEGA | MGI Sequence Detail 5667 Not Applicable 
polypeptide OTTMUSP00000019632 VEGA | MGI Sequence Detail 752 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(297 from dbSNP Build 137)    SNPs within 2kb including multiple locations(309)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003552 ATP-binding cassette sub-family B member 7, mitochondrial
References
(Earliest) J:39831 Savary S, et al., Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human. Genomics. 1997 Apr 15;41(2):275-8
(Latest) J:219775 Martelli A, et al., Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency. Cell Metab. 2015 Feb 3;21(2):311-22
All references(41)
Other
accession IDs
MGD-MRK-39532, MGI:2147832, MGI:2147959

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory