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Cdc37 Gene Detail
Summary
  • Symbol
    Cdc37
  • Name
    cell division cycle 37
  • Synonyms
    p50Cdc37
  • Feature Type
    protein coding gene
  • IDs
    MGI:109531
    NCBI Gene: 12539
  • Gene Overview
    MyGene.info: CDC37
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21138541-21149977 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.72 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109531
protein coding gene Chr9:21133222-21149982 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034442
protein coding gene Chr9:18322099-18333439 (-)
A/J MGP_AJ_G0034420
protein coding gene Chr9:18020275-18031640 (-)
AKR/J MGP_AKRJ_G0034347
protein coding gene Chr9:18348013-18359378 (-)
BALB/cJ MGP_BALBcJ_G0034411
protein coding gene Chr9:17914278-17925643 (-)
C3H/HeJ MGP_C3HHeJ_G0034123
protein coding gene Chr9:18652550-18663915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034932
protein coding gene Chr9:19065070-19076435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031862
protein coding gene Chr9:17148552-17160336 (-)
CAST/EiJ MGP_CASTEiJ_G0033446
protein coding gene Chr9:18477674-18489125 (-)
CBA/J MGP_CBAJ_G0034096
protein coding gene Chr9:19775529-19786869 (-)
DBA/2J MGP_DBA2J_G0034255
protein coding gene Chr9:17998546-18009911 (-)
FVB/NJ MGP_FVBNJ_G0034198
protein coding gene Chr9:17512118-17523457 (-)
LP/J MGP_LPJ_G0034340
protein coding gene Chr9:18496465-18507830 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034241
protein coding gene Chr9:21388212-21399553 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034952
protein coding gene Chr9:18298319-18309658 (-)
PWK/PhJ MGP_PWKPhJ_G0033152
protein coding gene Chr9:17973272-17984704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032986
protein coding gene Chr9:18358169-18369597 (-)
WSB/EiJ MGP_WSBEiJ_G0033561
protein coding gene Chr9:18026910-18038275 (-)



Homology
more
  • Human Ortholog
    CDC37, cell division cycle 37
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDC37, cell division cycle 37
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P50CDC37
  • Links
    NCBI Gene ID: 11140
    neXtProt AC: NX_Q16543
    UniProt: Q16543

  • Chr Location
    19p13.2; chr19:10391128-10403595 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12539 NCBI Gene Model | MGI Sequence Detail 11437 C57BL/6J ±  kb
    transcript NM_016742 RefSeq | MGI Sequence Detail 2456 C57BL/6  
    polypeptide Q61081 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 191
      Genomic 1
      cDNA 189
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39530
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:39400 Stepanova L, et al., Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 1996 Jun 15;10(12):1491-502
    • Latest
      J:203314 Erazo T, et al., Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol. 2013 Apr;33(8):1671-86

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory