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E4f1 Gene Detail
Summary
  • Symbol
    E4f1
  • Name
    E4F transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109530
    NCBI Gene: 13560
  • Gene Overview
    MyGene.info: E4F1
Location & Maps
more
  • Sequence Map
    Chr17:24443792-24455311 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.39 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    E4F1, E4F transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E4F1, E4F transcription factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    E4F
  • Links
    NCBI Gene ID: 1877
    neXtProt AC: NX_Q66K89

  • Chr Location
    16p13.3; chr16:2223488-2235742 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3259
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: E4F1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    10
  • Targeted
    4
  • Incidental Mutations
Homozygous null mice display early embryonic lethality with mitotic progression failure and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024137 Ensembl Gene Model | MGI Sequence Detail 11520 C57BL/6J ±  kb
transcript ENSMUST00000056032 Ensembl | MGI Sequence Detail 2561 Not Applicable  
polypeptide ENSMUSP00000062344 Ensembl | MGI Sequence Detail 782 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    275 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39529
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:39501 Fognani C, et al., Repression of adenovirus E1A enhancer activity by a novel zinc finger-containing DNA-binding protein related to the GLI-Kruppel protein. EMBO J. 1993 Dec 15;12(13):4985-92
  • Latest
    J:228251 Grote D, et al., E4F1 is a master regulator of CHK1-mediated functions. Cell Rep. 2015 Apr 14;11(2):210-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory