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E4f1
Gene Detail
 Symbol
Name
ID
E4f1
E4F transcription factor 1
MGI:109530
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:24443792-24455311 bp, - strand
From Ensembl annotation of GRCm38

  11520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3259  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: E4f1

Human
homologs
Human Homolog E4F1, E4F transcription factor 1
NCBI Gene ID 1877
neXtProt AC  NX_Q66K89
Human Synonyms  E4F
Human Chr (Location)  16p13.3; chr16:2223488-2235742 (+)  GRCh38
Alleles
and
phenotypes
All alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display early embryonic lethality with mitotic progression failure and increased apoptosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, nucleus, ...
Function cAMP response element binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (235)    Tissues (203)    Images (25)
Theiler Stages: 10, 17, 18, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 223
Northern blot 12
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024137 (Evidence)
Entrez Gene13560 (Evidence)
UniGene163132
DFCITC1579795, TC1594150, TC1613980, TC1700072
DoTSDT.101332201, DT.102540993, DT.110555458, DT.87068540, DT.91399215, DT.94198625, DT.97391927
NIA Mouse Gene IndexU037526
EC6.3.2.-
Consensus CDS ProjectCCDS28481.1
International Mouse Knockout Project StatusE4f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024137 Ensembl Gene Model | MGI Sequence Detail 11520 C57BL/6J ±  kb
transcript ENSMUST00000056032 Ensembl | MGI Sequence Detail 2561 Not Applicable 
polypeptide ENSMUSP00000062344 Ensembl | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(7) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000006860 transcription factor E4F1
References (Earliest) J:39501 Fognani C, et al., Repression of adenovirus E1A enhancer activity by a novel zinc finger-containing DNA-binding protein related to the GLI-Kruppel protein. EMBO J. 1993 Dec 15;12(13):4985-92
(Latest) J:182258 Taher L, et al., Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
All references(45)
Other
accession IDs
MGD-MRK-39529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory