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Trpc2
Gene Detail
 Symbol
Name
ID
Trpc2
transient receptor potential cation channel, subfamily C, member 2
MGI:109527
Synonyms 3010009O07Rik, mTrp2, trp2, TRPC2a, TRPC2b, Trrp2
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.71 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:102065511-102096864 bp, + strand
From VEGA annotation of GRCm38

  31354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135989  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc2

Alleles
and
phenotypes
All alleles(67) : Gene trapped(62) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit altered sexual and social behavior, including intermale mounting and a lack of aggressive behavior in the presence of invading males. Homozygotes for another allele show increased triglyceride levels in both males and females and increased cholesterol in males.
 
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process acrosome reaction, calcium ion transmembrane transport, ...
Component dendrite membrane, endomembrane system, ...
Function calcium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (98)    Tissues (72)    Images (18)
Theiler Stages: 17, 20, 22, 25, 26, 28
Assay TypeResults
RNA in situ 69
RT-PCR 29
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(15) Primer pair(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022733 (Evidence)
Ensembl Gene ModelENSMUSG00000070425 (Evidence)
Entrez Gene22064 (Evidence)
Consensus CDS ProjectCCDS52333.1
International Mouse Knockout Project StatusTrpc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022733 VEGA Gene Model | MGI Sequence Detail 31354 C57BL/6J ±  kb
transcript OTTMUST00000054529 VEGA | MGI Sequence Detail 4173 Not Applicable 
polypeptide OTTMUSP00000026045 VEGA | MGI Sequence Detail 1264 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(2) UniProt(11)
Polymorphisms PCR(1) : SNPs within 2kb(298 from dbSNP Build 137)    SNPs within 2kb including multiple locations(300)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR002706 DNA-repair protein Xrcc1, N-terminal
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005458 Transient receptor potential channel, canonical 2
Protein Ontology PR:000001725 transient receptor potential cation channel TRPC2
References (Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:210727 Omura M, et al., Trpc2-Expressing Sensory Neurons in the Main Olfactory Epithelium of the Mouse. Cell Rep. 2014 Jul 4;
All references(74)
Other
accession IDs
MGD-MRK-39526, MGI:1924097, MGI:2141869

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory