Trpc2
Gene Detail

Symbol Name ID

Trpc2 transient receptor potential cation channel, subfamily C, member 2 MGI:109527

Synonyms

3010009O07Rik, mTrp2, trp2, TRPC2a, TRPC2b, Trrp2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.71 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:102065511-102096864 bp, + strand From VEGA annotation of GRCm38   31354 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trpc2 ± 2 cM)

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc2

Human ortholog

TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene NCBI Gene ID 7221
Human Chr11:3647714-3658789 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(68) : Targeted(6) Gene trapped(62)
 

Homozygous null mice exhibit altered sexual and social behavior, including intermale mounting and a lack of aggressive behavior in the presence of invading males. Homozygotes for another allele show increased triglyceride levels in both males and females and increased cholesterol in males.

 

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	acrosome reaction, calcium ion transmembrane transport, ...
Component	dendrite membrane, endomembrane system, ...
Function	calcium channel activity, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (49)    Tissues (23)    Images (16)
Theiler Stages: 17, 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	20
RT-PCR	29

cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(80) Genomic(1) cDNA(73) Primer pair(5) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022733 (Evidence)
Ensembl Gene Model	ENSMUSG00000070425 (Evidence)
Entrez Gene	22064 (Evidence)
UniGene	292904
DFCI	TC1580911, TC1582559, TC1587428, TC1587893, TC1596457, TC1634181, TC1662635
DoTS	DT.101132307, DT.101237977, DT.101289375, DT.101381115, DT.110990327, DT.110990420, DT.110990672, DT.40135441, DT.485793, DT.526262, DT.91341315, DT.94219420, DT.97385887
NIA Mouse Gene Index	U175160
Consensus CDS Project	CCDS21524.2, CCDS52333.1
International Mouse Knockout Project Status	Trpc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022733	VEGA Gene Model | MGI Sequence Detail	31354	C57BL/6J
transcript	OTTMUST00000054529	VEGA | MGI Sequence Detail	4173	Not Applicable
polypeptide	OTTMUSP00000026045	VEGA | MGI Sequence Detail	1264	Not Applicable

All sequences(115) RefSeq(4) UniProt(16)

Polymorphisms

PCR(1) : SNPs(128 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR002706	DNA-repair protein Xrcc1, N-terminal
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR013555	Transient receptor ion channel domain
InterPro	IPR002153	Transient receptor potential channel, canonical
InterPro	IPR005458	Transient receptor potential channel, canonical 2
Protein Ontology	PR:000001725	transient receptor potential cation channel TRPC2

References

(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:191597 Kim S, et al., Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ. Nat Neurosci. 2012 Sep;15(9):1236-44
All references(77)

Other accession IDs

MGD-MRK-39526, MGI:1924097, MGI:2141869