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Trpc2 Gene Detail
Summary
  • Symbol
    Trpc2
  • Name
    transient receptor potential cation channel, subfamily C, member 2
  • Synonyms
    3010009O07Rik, mTrp2, trp2, TRPC2a, TRPC2b, Trrp2
Location &
Maps
more
  • Sequence Map
    Chr7:101732323-101745603 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.71 cM, cytoband F1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    548 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109527
 protein coding gene Chr7:101732323-101746071 (+)
129S1/SvImJ no annotation
A/J ENSMUSG00195054501
 protein coding gene Chr7:93080353-93093479 (+)
AKR/J ENSMUSG00220048230
 protein coding gene Chr7:86497026-86510151 (+)
BALB/cJ ENSMUSG00180031835
 protein coding gene Chr7:89753282-89766408 (+)
C3H/HeJ ENSMUSG00175021415
 protein coding gene Chr7:90407454-90420579 (+)
C57BL/6NJ ENSMUSG00215030289
 protein coding gene Chr7:89579531-89592612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030078
 protein coding gene Chr7:104787664-104801484 (+)
CAST/EiJ ENSTCUG00005052739
 protein coding gene Chr7:92986404-92999885 (+)
CBA/J ENSMUSG00210024904
 protein coding gene Chr7:90260862-90273986 (+)
DBA/2J ENSMUSG00185056221
 protein coding gene Chr7:94583350-94596475 (+)
FVB/NJ ENSMUSG00205028507
 protein coding gene Chr7:90251481-90264607 (+)
JF1/MsJ ENSUMUG00000044368
 protein coding gene Chr7:99485491-99499014 (+)
LP/J ENSMUSG00230043521
 protein coding gene Chr7:100684623-100697751 (+)
NOD/ShiLtJ ENSMUSG00190019290
 protein coding gene Chr7:90523952-90537053 (+)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010042604
 protein coding gene Chr7:88733260-88746781 (+)
SPRET/EiJ ENSMSPG00010011386
 protein coding gene Chr7:89980683-89993873 (+)
WSB/EiJ ENSIUOG00005008741
 protein coding gene Chr7:90841703-90854954 (+)



Homology
more
  • Human Ortholog
    TRPC2, transient receptor potential cation channel subfamily C member 2 (pseudogene)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC2, transient receptor potential cation channel subfamily C member 2 (pseudogene)
  • Synonyms
    TRPC2P
  • Links
    NCBI Gene ID: 7221

  • Chr Location
    11p15.4; chr11:3616679-3637677 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit altered sexual and social behavior, including intermale mounting and a lack of aggressive behavior in the presence of invading males. Homozygotes for another allele show increased triglyceride levels in both males and femalesand increased cholesterol in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    79
  • cDNA Data
    16
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000100254 Ensembl Gene Model | MGI Sequence Detail 13281 C57BL/6J ±  kb
    transcript ENSMUST00000124189 Ensembl | MGI Sequence Detail 2874 Not Applicable  
    polypeptide ENSMUSP00000116934 Ensembl | MGI Sequence Detail 890 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001725 short transient receptor potential cation channel TRPC2
      (term hierarchy)
    • InterPro Domains
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR056336 Calcium channel YVC1-like, C-terminal transmembrane domain
      IPR002706 DNA-repair protein Xrcc1, N-terminal
      IPR008979 Galactose-binding-like domain superfamily
      IPR013555 Transient receptor ion channel domain
      IPR002153 Transient receptor potential channel, canonical
      IPR005458 Transient receptor potential channel, canonical 2
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 17
      Primer pair 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39526, MGI:1924097, MGI:2141869
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 16
      Gene Ontology 20
      Phenotypes 73
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:367759 Liu D, et al., A hypothalamic circuit underlying the dynamic control of social homeostasis. Nature. 2025 Apr;640(8060):1000-1010
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory