Trpc3
Gene Detail

Symbol Name ID

Trpc3 transient receptor potential cation channel, subfamily C, member 3 MGI:109526

Synonyms

Trcp3, Trp3, Trrp3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

17.93 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:36620482-36690167 bp, - strand From VEGA annotation of GRCm38   69686 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20708  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc3

Human homologs

Human Homolog		TRPC3, transient receptor potential cation channel, subfamily C, member 3
NCBI Gene ID		7222
neXtProt AC		NX_Q13507
Human Synonyms		TRP3
Human Chr (Location)		4q27; chr4:122800183-122872909 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Chemically induced(1)
 

Homozygous knockout mice or mice heterozygoous for a point mutation in exon 7 display an abnormal gait. Abnormal nervous system electrophysiology is also described. An A1903G point mutation in exon 7 results in homozygous lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	integral to membrane, membrane
Function	calcium activated cation channel activity, calcium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (39)    Tissues (14)    Images (14)
Theiler Stages: 19, 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	10
RT-PCR	29

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(13) Primer pair(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006507 (Evidence)
Ensembl Gene Model	ENSMUSG00000027716 (Evidence)
Entrez Gene	22065 (Evidence)
UniGene	74363
DFCI	TC1583927
DoTS	DT.60105792, DT.91426760, DT.94184862
NIA Mouse Gene Index	U023951
Consensus CDS Project	CCDS50893.1
International Mouse Knockout Project Status	Trpc3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006507	VEGA Gene Model | MGI Sequence Detail	69686	C57BL/6J
transcript	OTTMUST00000014880	VEGA | MGI Sequence Detail	3694	Not Applicable
polypeptide	OTTMUSP00000006901	VEGA | MGI Sequence Detail	910	Not Applicable

All sequences(40) RefSeq(2) UniProt(7)

Polymorphisms

PCR(1) : SNPs(414 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR013555	Transient receptor ion channel domain
InterPro	IPR004729	Transient receptor potential channel
InterPro	IPR002153	Transient receptor potential channel, canonical
InterPro	IPR005459	Transient receptor potential channel, canonical 3
Protein Ontology	PR:000000775	transient receptor potential cation channel TRPC3

References

(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:190105 Tano JY, et al., Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages. Biochem Biophys Res Commun. 2012 Oct 12;427(1):178-84
All references(66)

Other accession IDs

MGD-MRK-39525, MGI:3687252