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Trpc3 Gene Detail
Summary
  • Symbol
    Trpc3
  • Name
    transient receptor potential cation channel, subfamily C, member 3
  • Synonyms
    Trcp3, Trp3, Trrp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109526
    NCBI Gene: 22065
  • Gene Overview
    MyGene.info: TRPC3
Location & Maps
more
  • Sequence Map
    Chr3:36620482-36690167 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69686 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TRPC3, transient receptor potential cation channel subfamily C member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPC3, transient receptor potential cation channel subfamily C member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCA41, TRP3
  • Links
    NCBI Gene ID: 7222
    neXtProt AC: NX_Q13507

  • Chr Location
    4q27; chr4:121879028-121951891 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TRPC3 associations

Human Disease Mouse Models
       Spinocerebellar Ataxia 41; SCA41   OMIM: 616410
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Radiation induced
    2
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    2 involving Trpc3
  • Incidental Mutations
Homozygous knockout mice or mice heterozygoous for a point mutation in exon 7 display an abnormal gait. Abnormal nervous system electrophysiology is also described. An A1903G point mutation in exon 7 results in homozygous lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006507 VEGA Gene Model | MGI Sequence Detail 69686 C57BL/6J ±  kb
transcript OTTMUST00000014880 VEGA | MGI Sequence Detail 3694 Not Applicable  
polypeptide OTTMUSP00000006901 VEGA | MGI Sequence Detail 910 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2210 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000000775 transient receptor potential cation channel TRPC3
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR005821 Ion transport domain
    IPR013555 Transient receptor ion channel domain
    IPR004729 Transient receptor potential channel
    IPR002153 Transient receptor potential channel, canonical
    IPR005459 Transient receptor potential channel, canonical 3
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 13
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-39525, MGI:3687252
References
more
  • Summaries
    All 81
    Developmental Gene Expression 19
    Gene Ontology 5
    Phenotypes 36
  • Earliest
    J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
  • Latest
    J:228754 Sexton JE, et al., The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing. Neurosci Lett. 2016 Jan 1;610:36-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory