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Trpc3
Gene Detail
 Symbol
Name
ID
Trpc3
transient receptor potential cation channel, subfamily C, member 3
MGI:109526
Synonyms Trcp3, Trp3, Trrp3
Feature Type protein coding gene
Genetic Map
Chromosome 3
17.93 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:36620482-36690167 bp, - strand
From VEGA annotation of GRCm38

  69686 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20708  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc3

Human
homologs
Human Homolog TRPC3, transient receptor potential cation channel, subfamily C, member 3
NCBI Gene ID 7222
neXtProt AC  NX_Q13507
Human Synonyms  TRP3
Human Chr (Location)  4q27; chr4:121879028-121951754 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous knockout mice or mice heterozygoous for a point mutation in exon 7 display an abnormal gait. Abnormal nervous system electrophysiology is also described. An A1903G point mutation in exon 7 results in homozygous lethality.
 
Interactions
Trpc3 interacts with 145 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral component of membrane, membrane
Function calcium activated cation channel activity, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (88)    Tissues (66)    Images (16)
Theiler Stages: 19, 20, 22, 25, 26, 27, 28
Assay TypeResults
RNA in situ 59
RT-PCR 29
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(13) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006507 (Evidence)
Ensembl Gene ModelENSMUSG00000027716 (Evidence)
Entrez Gene22065 (Evidence)
UniGene74363
DFCITC1583927
DoTSDT.60105792, DT.91426760, DT.94184862
NIA Mouse Gene IndexU023951
Consensus CDS ProjectCCDS50893.1
International Mouse Knockout Project StatusTrpc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006507 VEGA Gene Model | MGI Sequence Detail 69686 C57BL/6J ±  kb
transcript OTTMUST00000014880 VEGA | MGI Sequence Detail 3694 Not Applicable 
polypeptide OTTMUSP00000006901 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(7)
Polymorphisms PCR(1) : SNPs within 2kb(1031 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005459 Transient receptor potential channel, canonical 3
Protein Ontology PR:000000775 transient receptor potential cation channel TRPC3
References (Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:210682 Lee KP, et al., Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1). J Biol Chem. 2014 Mar 7;289(10):6372-82
All references(73)
Other
accession IDs
MGD-MRK-39525, MGI:3687252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory