Trpc4
Gene Detail

Symbol Name ID

Trpc4 transient receptor potential cation channel, subfamily C, member 4 MGI:109525

Synonyms

CCE1, STRPC4, Trp4, Trrp4

Feature Type

protein coding gene

Genetic Map

Chromosome 3

25.43 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:54156057-54318470 bp, + strand From Ensembl annotation of GRCm38   162414 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc4

Human homologs

Human Homolog		TRPC4, transient receptor potential cation channel, subfamily C, member 4
NCBI Gene ID		7223
neXtProt AC		NX_Q9UBN4
Human Synonyms		HTRP4, HTRP-4, TRP4
Human Chr (Location)		13q13.3; chr13:38210773-38443939 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice exhibit a significant reduction in agonist-induced Ca2+ entry and vasorelaxation of aortic rings.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	calcium ion import, calcium ion transmembrane transport, ...
Component	basolateral plasma membrane, calcium channel complex, ...
Function	beta-catenin binding, cadherin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (92)    Tissues (55)    Images (6)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	46
Western blot	7
RT-PCR	34

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(1) cDNA(19) Primer pair(6)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000027748 (Evidence)
Entrez Gene	22066 (Evidence)
UniGene	10100
DFCI	TC1584004, TC1595677, TC1604079, TC1619460
DoTS	DT.101725914, DT.103549767, DT.40144471, DT.91377911
NIA Mouse Gene Index	U003235
Consensus CDS Project	CCDS17350.1
International Mouse Knockout Project Status	Trpc4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000027748	Ensembl Gene Model | MGI Sequence Detail	162414	C57BL/6J
transcript	ENSMUST00000029311	Ensembl | MGI Sequence Detail	3472	Not Applicable
polypeptide	ENSMUSP00000029311	Ensembl | MGI Sequence Detail	974	Not Applicable

All sequences(39) RefSeq(7) UniProt(4)

Polymorphisms

PCR(1) : SNPs(743 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR013555	Transient receptor ion channel domain
InterPro	IPR004729	Transient receptor potential channel
InterPro	IPR002153	Transient receptor potential channel, canonical
InterPro	IPR005460	Transient receptor potential channel, canonical 4
Protein Ontology	PR:000001075	transient receptor potential cation channel TRPC4

References

(Earliest) J:40448 Petersen CC, et al., Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Biochem J. 1995 Oct 1;311(Pt 1):41-4
(Latest) J:194590 Phelan KD, et al., Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013 Feb;83(2):429-38
All references(62)

Other accession IDs

MGD-MRK-39524