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Trpc4 Gene Detail
Summary
  • Symbol
    Trpc4
  • Name
    transient receptor potential cation channel, subfamily C, member 4
  • Synonyms
    CCE1, STRPC4, Trp4, Trrp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109525
    NCBI Gene: 22066
  • Gene Overview
    MyGene.info: TRPC4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54156051-54318471 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 25.43 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1060 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109525
protein coding gene Chr3:54156035-54318471 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027210
protein coding gene Chr3:52809422-52980563 (+)
A/J MGP_AJ_G0027170
protein coding gene Chr3:51192887-51360234 (+)
AKR/J MGP_AKRJ_G0027140
protein coding gene Chr3:52238025-52409995 (+)
BALB/cJ MGP_BALBcJ_G0027183
protein coding gene Chr3:51045783-51217339 (+)
C3H/HeJ MGP_C3HHeJ_G0026926
protein coding gene Chr3:52464988-52637754 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027629
protein coding gene Chr3:54844721-55027632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024988
protein coding gene Chr3:47736710-47898451 (+)
CAST/EiJ MGP_CASTEiJ_G0026378
protein coding gene Chr3:52575246-52750247 (+)
CBA/J MGP_CBAJ_G0026902
protein coding gene Chr3:56582657-56765594 (+)
DBA/2J MGP_DBA2J_G0027036
protein coding gene Chr3:50761267-50929611 (+)
FVB/NJ MGP_FVBNJ_G0027004
protein coding gene Chr3:49739766-49904511 (+)
LP/J MGP_LPJ_G0027148
protein coding gene Chr3:53521858-53697277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027022
protein coding gene Chr3:60698672-60887602 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027687
protein coding gene Chr3:52146254-52324272 (+)
PWK/PhJ MGP_PWKPhJ_G0026110
protein coding gene Chr3:50434821-50596504 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025923
protein coding gene Chr3:51890439-52067240 (+)
WSB/EiJ MGP_WSBEiJ_G0026452
protein coding gene Chr3:52275885-52454494 (+)



Homology
more
  • Human Ortholog
    TRPC4, transient receptor potential cation channel subfamily C member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPC4, transient receptor potential cation channel subfamily C member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTRP4, HTRP-4, TRP4
  • Links
    NCBI Gene ID: 7223
    neXtProt AC: NX_Q9UBN4
    UniProt: Q9UBN4

  • Chr Location
    13q13.3; chr13:37633872-37870374 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a significant reduction in agonist-induced Ca2+ entry and vasorelaxation of aortic rings.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22066 NCBI Gene Model | MGI Sequence Detail 162421 C57BL/6J ±  kb
transcript NM_016984 RefSeq | MGI Sequence Detail 3490 C57BL/6  
polypeptide Q9QUQ5 UniProt | EBI | MGI Sequence Detail 974 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 16
    Primer pair 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-39524
References
more
  • Summaries
    All 81
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 13
    Phenotypes 23
  • Earliest
    J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
  • Latest
    J:264217 Cheung SY, et al., TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A. Oncotarget. 2018 Jul 3;9(51):29634-29643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory