About   Help   FAQ
Trpc4
Gene Detail
 Symbol
Name
ID
Trpc4
transient receptor potential cation channel, subfamily C, member 4
MGI:109525
Synonyms CCE1, STRPC4, Trp4, Trrp4
Feature Type protein coding gene
Genetic Map
Chromosome 3
25.43 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:54156057-54318470 bp, + strand
From Ensembl annotation of GRCm38

  162414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc4

Human
homologs
Human Homolog TRPC4, transient receptor potential cation channel, subfamily C, member 4
NCBI Gene ID 7223
neXtProt AC  NX_Q9UBN4
Human Synonyms  HTRP4, HTRP-4, TRP4
Human Chr (Location)  13q13.3; chr13:37636636-37869802 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a significant reduction in agonist-induced Ca2+ entry and vasorelaxation of aortic rings.
 
Interactions
Trpc4 interacts with 125 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component basolateral plasma membrane, calcium channel complex, ...
Function beta-catenin binding, cadherin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (141)    Tissues (109)    Images (8)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 95
Western blot 7
RT-PCR 34
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(15) Primer pair(6)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000027748 (Evidence)
Entrez Gene22066 (Evidence)
DFCITC1584004, TC1595677, TC1604079, TC1619460
DoTSDT.101725914, DT.103549767, DT.40144471, DT.91377911
NIA Mouse Gene IndexU003235
Consensus CDS ProjectCCDS17350.1
International Mouse Knockout Project StatusTrpc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027748 Ensembl Gene Model | MGI Sequence Detail 162414 C57BL/6J ±  kb
transcript ENSMUST00000029311 Ensembl | MGI Sequence Detail 3472 Not Applicable 
polypeptide ENSMUSP00000029311 Ensembl | MGI Sequence Detail 974 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(13) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(1062 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005460 Transient receptor potential channel, canonical 4
Protein Ontology PR:000001075 transient receptor potential cation channel TRPC4
References (Earliest) J:40448 Petersen CC, et al., Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Biochem J. 1995 Oct 1;311(Pt 1):41-4
(Latest) J:204700 Boudes M, et al., Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity. PLoS One. 2013;8(7):e69550
All references(63)
Other
accession IDs
MGD-MRK-39524

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory