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Trpc4
Gene Detail
Symbol

Name
ID
Trpc4
transient receptor potential cation channel, subfamily C, member 4
MGI:109525
Synonyms
CCE1, STRPC4, Trp4, Trrp4
Feature Type
protein coding gene
Genetic Map
Chromosome 3
25.43 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:54156057-54318470 bp, + strand
From Ensembl annotation of GRCm38

  162414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRPC4
Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc4

Human
homologs
TRPC4, transient receptor potential cation channel, subfamily C, member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7223
neXtProt AC: NX_Q9UBN4

Human Synonyms: HTRP4, HTRP-4, TRP4

Human Chr (Location): 13q13.3; chr13:37633872-37869802 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a significant reduction in agonist-induced Ca2+ entry and vasorelaxation of aortic rings.
 
Interactions
Trpc4 interacts with 125 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component basolateral plasma membrane, calcium channel complex, ...
Function beta-catenin binding, cadherin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (141)    Tissues (109)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 95
Western blot 7
RT-PCR 34
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trpc4 ; ZFIN trpc4a, trpc4b    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(15) Primer pair(6)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000027748 (Evidence)
Entrez Gene 22066 (Evidence)
DFCI TC1604079, TC1595677, TC1584004, TC1619460
DoTS DT.101725914, DT.91377911, DT.40144471, DT.103549767
NIA Mouse Gene Index U003235
Consensus CDS Project CCDS17350.1
International Mouse Phenotyping Consortium Status Trpc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027748 Ensembl Gene Model | MGI Sequence Detail 162414 C57BL/6J ±  kb
transcript ENSMUST00000029311 Ensembl | MGI Sequence Detail 3472 Not Applicable 
polypeptide ENSMUSP00000029311 Ensembl | MGI Sequence Detail 974 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(13) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(1062 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005460 Transient receptor potential channel, canonical 4
Protein Ontology PR:000001075 transient receptor potential cation channel TRPC4
References
(Earliest) J:40448 Petersen CC, et al., Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Biochem J. 1995 Oct 1;311(Pt 1):41-4
(Latest) J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47
All references(65)
Other
accession IDs
MGD-MRK-39524

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory