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Trpc5 Gene Detail
Summary
  • Symbol
    Trpc5
  • Name
    transient receptor potential cation channel, subfamily C, member 5
  • Synonyms
    CCE2, TRP5, Trrp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109524
    NCBI Gene: 22067
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:143164667-143471176 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 65.49 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109524
 protein coding gene ChrX:143160323-143471176 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036159
 protein coding gene ChrX:141936647-142248630 (-)
A/J MGP_AJ_G0036136
 protein coding gene ChrX:141248394-141578882 (-)
AKR/J MGP_AKRJ_G0036062
 protein coding gene ChrX:145853542-146181741 (-)
BALB/cJ MGP_BALBcJ_G0036127
 protein coding gene ChrX:139496223-139814458 (-)
C3H/HeJ MGP_C3HHeJ_G0035835
 protein coding gene ChrX:142033319-142366487 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036650
 protein coding gene ChrX:145950093-146258429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033474
 protein coding gene ChrX:132828427-133113150 (-)
CAST/EiJ MGP_CASTEiJ_G0035126
 protein coding gene ChrX:122690836-122990731 (-)
CBA/J MGP_CBAJ_G0035812
 protein coding gene ChrX:150447298-150779625 (-)
DBA/2J MGP_DBA2J_G0035970
 protein coding gene ChrX:140346182-140642500 (-)
FVB/NJ MGP_FVBNJ_G0035904
 protein coding gene ChrX:139556551-139861052 (-)
LP/J MGP_LPJ_G0036061
 protein coding gene ChrX:142879475-143204228 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035940
 protein coding gene ChrX:158240459-158578460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036687
 protein coding gene ChrX:141237680-141554533 (-)
PWK/PhJ MGP_PWKPhJ_G0034820
 protein coding gene ChrX:119474983-119751696 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034645
 protein coding gene ChrX:123231856-123541040 (-)
WSB/EiJ MGP_WSBEiJ_G0035261
 protein coding gene ChrX:139588118-139898779 (-)



Homology
more
  • Human Ortholog
    TRPC5, transient receptor potential cation channel subfamily C member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC5, transient receptor potential cation channel subfamily C member 5
  • Synonyms
    PPP1R159, TRP5
  • Links
    NCBI Gene ID: 7224
    neXtProt AC: NX_Q9UL62
    UniProt: Q9UL62

  • Chr Location
    Xq23; chrX:111768011-112082776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with homozygous null alleles of the gene exhibit diminished innate fear response with reduction in synaptic activation and strength in neurons of the amygdala. Mice homozygous for a null allele exhibit reduced female fertility with reduced prolactin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    105
  • cDNA Data
    13
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041710 Ensembl Gene Model | MGI Sequence Detail 306510 C57BL/6J ±  kb
    transcript ENSMUST00000040184 Ensembl | MGI Sequence Detail 4158 Not Applicable  
    polypeptide ENSMUSP00000049063 Ensembl | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 14
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39523
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 53
    • Earliest
      J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
    • Latest
      J:340130 Lin Y, et al., TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis. Int Immunopharmacol. 2023 Feb;115:109655
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory