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Trpc5
Gene Detail
 Symbol
Name
ID
Trpc5
transient receptor potential cation channel, subfamily C, member 5
MGI:109524
Synonyms CCE2, TRP5, Trrp5
Feature Type protein coding gene
Genetic Map
Chromosome X
65.49 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:144381671-144688180 bp, - strand
From VEGA annotation of GRCm38

  306510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74915  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc5

Human
homologs
Human Homolog TRPC5, transient receptor potential cation channel, subfamily C, member 5
NCBI Gene ID 7224
neXtProt AC  NX_Q9UL62
Human Synonyms  PPP1R159, TRP5
Human Chr (Location)  Xq23; chrX:111774314-112082776 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with homozygous null alleles of the gene exhibit diminished innate fear response with reduction in synaptic activation and strength in neurons of the amygdala.
 
Interactions
Trpc5 interacts with 213 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component calcium channel complex, integral component of membrane, ...
Function calcium channel activity, inositol 1,4,5 trisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (85)    Tissues (60)    Images (6)
Theiler Stages: 20, 22, 25, 26, 28
Assay TypeResults
RNA in situ 49
RT-PCR 36
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(18) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018934 (Evidence)
Ensembl Gene ModelENSMUSG00000041710 (Evidence)
Entrez Gene22067 (Evidence)
UniGene328378
DFCITC1586519
DoTSDT.87049330
NIA Mouse Gene IndexU039761, U373233
Consensus CDS ProjectCCDS30457.1
International Mouse Knockout Project StatusTrpc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018934 VEGA Gene Model | MGI Sequence Detail 306510 C57BL/6J ±  kb
transcript OTTMUST00000045505 VEGA | MGI Sequence Detail 4158 Not Applicable 
polypeptide OTTMUSP00000020456 VEGA | MGI Sequence Detail 975 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(831 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005461 Transient receptor potential channel, canonical 5
Protein Ontology PR:000016695 short transient receptor potential channel 5
References (Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:207854 Schaldecker T, et al., Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest. 2013 Dec 2;123(12):5298-309
All references(55)
Other
accession IDs
MGD-MRK-39523

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory