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Trpc5
Gene Detail
Symbol

Name
ID
Trpc5
transient receptor potential cation channel, subfamily C, member 5
MGI:109524
Synonyms
CCE2, TRP5, Trrp5
Feature Type
protein coding gene
Genetic Map
Chromosome X
65.49 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:144381671-144688180 bp, - strand
From VEGA annotation of GRCm38

  306510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74915  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRPC5
Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc5

Human
homologs
TRPC5, transient receptor potential cation channel, subfamily C, member 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7224
neXtProt AC: NX_Q9UL62

Human Synonyms: PPP1R159, TRP5

Human Chr (Location): Xq23; chrX:111774314-112082776 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice with homozygous null alleles of the gene exhibit diminished innate fear response with reduction in synaptic activation and strength in neurons of the amygdala.
 
Interactions
Trpc5 interacts with 213 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component calcium channel complex, cytoplasm, ...
Function actin binding, actinin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (85)    Tissues (63)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
RT-PCR 36
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trpc5 ; ZFIN trpc5a    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(13) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018934 (Evidence)
Ensembl Gene Model ENSMUSG00000041710 (Evidence)
Entrez Gene 22067 (Evidence)
DFCI TC1586519
DoTS DT.103547439, DT.87049330
NIA Mouse Gene Index U020287, U039761, U373233
Consensus CDS Project CCDS30457.1
International Mouse Phenotyping Consortium Status Trpc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018934 VEGA Gene Model | MGI Sequence Detail 306510 C57BL/6J ±  kb
transcript OTTMUST00000045505 VEGA | MGI Sequence Detail 4158 Not Applicable 
polypeptide OTTMUSP00000020456 VEGA | MGI Sequence Detail 975 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(831 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005461 Transient receptor potential channel, canonical 5
Protein Ontology PR:000016695 short transient receptor potential channel 5
References
(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47
All references(55)
Other
accession IDs
MGD-MRK-39523

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory