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Trpc5 Gene Detail
Summary
  • Symbol
    Trpc5
  • Name
    transient receptor potential cation channel, subfamily C, member 5
  • Synonyms
    CCE2, TRP5, Trrp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109524
    NCBI Gene: 22067
  • Gene Overview
    MyGene.info: TRPC5
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:144381671-144688180 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 65.49 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109524
protein coding gene ChrX:144377327-144688180 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036159
protein coding gene ChrX:141936647-142248630 (-)
A/J MGP_AJ_G0036136
protein coding gene ChrX:141248394-141578882 (-)
AKR/J MGP_AKRJ_G0036062
protein coding gene ChrX:145853542-146181741 (-)
BALB/cJ MGP_BALBcJ_G0036127
protein coding gene ChrX:139496223-139814458 (-)
C3H/HeJ MGP_C3HHeJ_G0035835
protein coding gene ChrX:142033319-142366487 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036650
protein coding gene ChrX:145950093-146258429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033474
protein coding gene ChrX:132828427-133113150 (-)
CAST/EiJ MGP_CASTEiJ_G0035126
protein coding gene ChrX:122690836-122990731 (-)
CBA/J MGP_CBAJ_G0035812
protein coding gene ChrX:150447298-150779625 (-)
DBA/2J MGP_DBA2J_G0035970
protein coding gene ChrX:140346182-140642500 (-)
FVB/NJ MGP_FVBNJ_G0035904
protein coding gene ChrX:139556551-139861052 (-)
LP/J MGP_LPJ_G0036061
protein coding gene ChrX:142879475-143204228 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035940
protein coding gene ChrX:158240459-158578460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036687
protein coding gene ChrX:141237680-141554533 (-)
PWK/PhJ MGP_PWKPhJ_G0034820
protein coding gene ChrX:119474983-119751696 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034645
protein coding gene ChrX:123231856-123541040 (-)
WSB/EiJ MGP_WSBEiJ_G0035261
protein coding gene ChrX:139588118-139898779 (-)



Homology
more
  • Human Ortholog
    TRPC5, transient receptor potential cation channel subfamily C member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRPC5, transient receptor potential cation channel subfamily C member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PPP1R159, TRP5
  • Links
    NCBI Gene ID: 7224
    neXtProt AC: NX_Q9UL62
    UniProt: Q9UL62

  • Chr Location
    Xq23; chrX:111774314-112082943 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with homozygous null alleles of the gene exhibit diminished innate fear response with reduction in synaptic activation and strength in neurons of the amygdala.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041710 Ensembl Gene Model | MGI Sequence Detail 306510 C57BL/6J ±  kb
transcript ENSMUST00000040184 Ensembl | MGI Sequence Detail 4158 Not Applicable  
polypeptide ENSMUSP00000049063 Ensembl | MGI Sequence Detail 975 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 14
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39523
References
more
  • Summaries
    All 75
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
  • Latest
    J:264217 Cheung SY, et al., TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A. Oncotarget. 2018 Jul 3;9(51):29634-29643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory