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Ugt8a
Gene Detail
Symbol

Name
ID
Ugt8a
UDP galactosyltransferase 8A
MGI:109522
Synonyms
Cgt, mCerGT, Ugt8
Feature Type
protein coding gene
Genetic Map
Chromosome 3
54.68 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:125865359-125938550 bp, - strand
From Ensembl annotation of GRCm38

  73192 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UGT8
Protein SuperFamily: glucuronosyltransferase
Gene Tree: Ugt8a

Human
homologs
UGT8, UDP glycosyltransferase 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7368
neXtProt AC: NX_Q16880

Human Synonyms: CGT, UGT4

Human Chr (Location): 4q26; chr4:114598403-114678225 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants fail to make galactolipid galactocerebroside and its sulfated derivative that are normal myelin constituents. Mutants have tremors, ataxia, progressive hindlimb paralysis and vacuole formation in ventral spinal cord due to abnormal myelin sheath.
 
Phenotype Images(2)
Interactions
Ugt8a interacts with 325 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (10 records)
Data Summary: Results (25)    Tissues (22)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 16
RT-PCR 9
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(15) cDNA(21) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000032854 (Evidence)
Entrez Gene 22239 (Evidence)
UniGene 306021
DFCI TC1583771, TC1611569
DoTS DT.101399848, DT.60103316, DT.87026732, DT.97366411
NIA Mouse Gene Index U024619
EC 2.4.1.45
Consensus CDS Project CCDS17821.1
International Mouse Phenotyping Consortium Status Ugt8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032854 Ensembl Gene Model | MGI Sequence Detail 73192 C57BL/6J ±  kb
transcript ENSMUST00000057944 Ensembl | MGI Sequence Detail 3583 Not Applicable 
polypeptide ENSMUSP00000050852 Ensembl | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(836 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
Protein Ontology PR:000017068 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
References
(Earliest) J:33930 Bosio A, et al., Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase). Genomics. 1996 Jul 1;35(1):223-6
(Latest) J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
All references(75)
Other
accession IDs
MGD-MRK-36113, MGD-MRK-39521, MGI:2139820, MGI:2139983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory