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Ugt8a
Gene Detail
 Symbol
Name
ID
Ugt8a
UDP galactosyltransferase 8A
MGI:109522
Synonyms Cgt, mCerGT, Ugt8
Feature Type protein coding gene
Genetic Map
Chromosome 3
54.68 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:125865359-125938550 bp, - strand
From Ensembl annotation of GRCm38

  73192 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glucuronosyltransferase
Gene Tree: Ugt8a

Human
homologs
Human Homolog UGT8, UDP glycosyltransferase 8
NCBI Gene ID 7368
neXtProt AC  NX_Q16880
Human Synonyms  CGT, UGT4
Human Chr (Location)  4q26; chr4:114598455-114678225 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants fail to make galactolipid galactocerebroside and its sulfated derivative that are normal myelin constituents. Mutants have tremors, ataxia, progressive hindlimb paralysis and vacuole formation in ventral spinal cord due to abnormal myelin sheath.
 
Phenotype Images(2)
Interactions
Ugt8a interacts with 326 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process axon cargo transport, cellular response to hormone stimulus, ...
Component cell, integral component of membrane, ...
Function 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity, ceramide glucosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (27)    Tissues (24)    Images (2)
Theiler Stages: 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 18
RT-PCR 9
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(15) cDNA(21) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000032854 (Evidence)
Entrez Gene22239 (Evidence)
UniGene306021
DFCITC1583771, TC1611569
DoTSDT.101399848, DT.60103316, DT.87026732, DT.97366411
NIA Mouse Gene IndexU024619
EC2.4.1.45
Consensus CDS ProjectCCDS17821.1
International Mouse Knockout Project StatusUgt8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032854 Ensembl Gene Model | MGI Sequence Detail 73192 C57BL/6J ±  kb
transcript ENSMUST00000057944 Ensembl | MGI Sequence Detail 3583 Not Applicable 
polypeptide ENSMUSP00000050852 Ensembl | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(836 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
Protein Ontology PR:000017068 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
References (Earliest) J:33930 Bosio A, et al., Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase). Genomics. 1996 Jul 1;35(1):223-6
(Latest) J:193501 Yu Y, et al., Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013 Jan 17;152(1-2):248-61
All references(76)
Other
accession IDs
MGD-MRK-36113, MGD-MRK-39521, MGI:2139820, MGI:2139983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory