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Lgals9
Gene Detail
Symbol

Name
ID
Lgals9
lectin, galactose binding, soluble 9
MGI:109496
Synonyms
gal-9, galectin-9, LGALS35, Lgals5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:78962974-78984946 bp, - strand
From VEGA annotation of GRCm38

  21973 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 western clawed frog

HCOP human homology predictions: LGALS9B
Protein SuperFamily: galectin
Gene Tree: Lgals9

Human
homologs
LGALS9B, lectin, galactoside-binding, soluble, 9B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 284194
neXtProt AC: NX_Q3B8N2

Human Chr (Location): 17p11.2; chr17:20449395-20467535 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Genomic Mutations involving Lgals9 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased susceptibility to collagen-induced arthritis, increased T-helper 1 cells and decreased regulatory T cells.
 
Interactions
Lgals9 interacts with 65 markers (Mir19b-1, Mir19b-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to virus, female pregnancy, ...
Component cytoplasm, extracellular region, ...
Function carbohydrate binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (174)    Tissues (45)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 100
Northern blot 39
Western blot 3
RT-PCR 13
cDNA source data(149)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lgals9    NEW 
Molecular
reagents
All nucleic(153) Genomic(1) cDNA(150) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000163 (Evidence)
Ensembl Gene Model ENSMUSG00000001123 (Evidence)
Entrez Gene 16859 (Evidence)
UniGene 341434
DFCI TC1573879, TC1599420, TC1606179
DoTS DT.97337126, DT.493643, DT.102558617
NIA Mouse Gene Index U033142
PDB 2D6M, 2D6L, 2D6K, 2D6N, 2D6P, 2D6O
Consensus CDS Project CCDS25116.1, CCDS48858.1
International Mouse Phenotyping Consortium Status Lgals9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000163 VEGA Gene Model | MGI Sequence Detail 21973 C57BL/6J ±  kb
transcript OTTMUST00000000502 VEGA | MGI Sequence Detail 1074 Not Applicable 
polypeptide OTTMUSP00000000222 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001079 Galectin, carbohydrate recognition domain
Protein Ontology PR:000009776 galectin-9
References
(Earliest) J:24467 Gitt MA, et al., Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes. J Biol Chem. 1995 Mar 10;270(10):5032-8
(Latest) J:214521 Madireddi S, et al., Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med. 2014 Jun 30;211(7):1433-48
All references(60)
Other
accession IDs
MGD-MRK-24103, MGD-MRK-39495, MGI:103231, MGI:2143968, MGI:2144080, MGI:2144105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory