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Lgals9 Gene Detail
Summary
  • Symbol
    Lgals9
  • Name
    lectin, galactose binding, soluble 9
  • Synonyms
    gal-9, galectin-9, LGALS35, Lgals5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109496
    NCBI Gene: 16859
  • Gene Overview
    MyGene.info: LGALS9
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78962979-78984924 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109496
protein coding gene Chr11:78962974-78984946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018792
protein coding gene Chr11:80024187-80046147 (-)
A/J MGP_AJ_G0018759
protein coding gene Chr11:76950208-76972757 (-)
AKR/J MGP_AKRJ_G0018729
protein coding gene Chr11:79257893-79279872 (-)
BALB/cJ MGP_BALBcJ_G0018732
protein coding gene Chr11:77361767-77383730 (-)
C3H/HeJ MGP_C3HHeJ_G0018546
protein coding gene Chr11:79306044-79331181 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019184
protein coding gene Chr11:82486982-82510322 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016819
protein coding gene Chr11:73907905-73930659 (-)
CAST/EiJ MGP_CASTEiJ_G0018101
protein coding gene Chr11:79772815-79795127 (-)
CBA/J MGP_CBAJ_G0018517
protein coding gene Chr11:86074906-86097062 (-)
DBA/2J MGP_DBA2J_G0018625
protein coding gene Chr11:76516505-76538514 (-)
FVB/NJ MGP_FVBNJ_G0018614
protein coding gene Chr11:76110516-76132526 (-)
LP/J MGP_LPJ_G0018695
protein coding gene Chr11:80540255-80562309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018641
protein coding gene Chr11:86463398-86485425 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019224
protein coding gene Chr11:79517724-79539739 (-)
PWK/PhJ MGP_PWKPhJ_G0017871
protein coding gene Chr11:77321211-77343363 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017662
protein coding gene Chr11:79132995-79158809 (-)
WSB/EiJ MGP_WSBEiJ_G0018153
protein coding gene Chr11:79341988-79365553 (-)



Homology
more
  • Human Ortholog
    LGALS9, galectin 9
  • Vertebrate Orthologs
    4
  • Human Ortholog
    LGALS9, galectin 9
    Orthology source: HGNC
  • Synonyms
    HUAT, LGALS9A
  • Links
    NCBI Gene ID: 3965
    neXtProt AC: NX_O00182
    UniProt: O00182

  • Chr Location
    17q11.2; chr17:27631148-27649560 (+)  GRCh38.p7

  • Human Ortholog
    LGALS9B, galectin 9B
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 284194
    neXtProt AC: NX_Q3B8N2
    UniProt: Q3B8N2

  • Chr Location
    17p11.2; chr17:20449863-20467535 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to collagen-induced arthritis, increased T-helper 1 cells and decreased regulatory T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16859 NCBI Gene Model | MGI Sequence Detail 21946 C57BL/6J ±  kb
    transcript NM_010708 RefSeq | MGI Sequence Detail 1586 C57BL/6NCrl  
    polypeptide O08573 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 154
      Genomic 1
      cDNA 151
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24103, MGD-MRK-39495, MGI:103231, MGI:2143968, MGI:2144080, MGI:2144105
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261108 Liang CC, et al., Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis. Am J Pathol. 2018 May;188(5):1225-1235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory