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Lgals9
Gene Detail
 Symbol
Name
ID
Lgals9
lectin, galactose binding, soluble 9
MGI:109496
Synonyms gal-9, galectin-9, LGALS35, Lgals5
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:78962974-78984946 bp, - strand
From VEGA annotation of GRCm38

  21973 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat

Protein SuperFamily: galectin
Gene Tree: Lgals9

Human
homologs
Human Homolog LGALS9B, lectin, galactoside-binding, soluble, 9B
NCBI Gene ID 284194
neXtProt AC  NX_Q3B8N2
Human Chr (Location)  17p11.2; chr17:20449395-20467535 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased susceptibility to collagen-induced arthritis, increased T-helper 1 cells and decreased regulatory T cells.
 
Interactions
Lgals9 interacts with 65 markers (Mir19b-1, Mir19b-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process heterophilic cell-cell adhesion
Component cytoplasm, extracellular region
Function carbohydrate binding, galactoside binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (174)    Tissues (40)    Images (79)
Theiler Stages: 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 19
RNA in situ 100
Northern blot 39
Western blot 3
RT-PCR 13
cDNA source data(149)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(153) Genomic(1) cDNA(150) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000163 (Evidence)
Ensembl Gene ModelENSMUSG00000001123 (Evidence)
Entrez Gene16859 (Evidence)
UniGene341434
DFCITC1573879, TC1599420, TC1606179
DoTSDT.102558617, DT.493643, DT.97337126
NIA Mouse Gene IndexU033142
PDB2D6K, 2D6L, 2D6M, 2D6N, 2D6O, 2D6P
Consensus CDS ProjectCCDS25116.1, CCDS48858.1
International Mouse Knockout Project StatusLgals9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000163 VEGA Gene Model | MGI Sequence Detail 21973 C57BL/6J ±  kb
transcript OTTMUST00000000502 VEGA | MGI Sequence Detail 1074 Not Applicable 
polypeptide OTTMUSP00000000222 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001079 Galectin, carbohydrate recognition domain
Protein Ontology PR:000009776 galectin-9
References (Earliest) J:24467 Gitt MA, et al., Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes. J Biol Chem. 1995 Mar 10;270(10):5032-8
(Latest) J:203452 Steelman AJ, et al., Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013 Aug 16;288(33):23776-87
All references(57)
Other
accession IDs
MGD-MRK-24103, MGD-MRK-39495, MGI:103231, MGI:2143968, MGI:2144080, MGI:2144105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory