Lgals9
Gene Detail

Symbol Name ID

Lgals9 lectin, galactose binding, soluble 9 MGI:109496

Synonyms

gal-9, galectin-9, LGALS35, Lgals5

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:78962974-78984946 bp, - strand From VEGA annotation of GRCm38   21973 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 5 zebrafish

Protein SuperFamily: galectin
Gene Tree: Lgals9

Human homologs

Human Homolog		LGALS9, lectin, galactoside-binding, soluble, 9
NCBI Gene ID		3965
neXtProt AC		NX_O00182
Human Synonyms		HUAT, LGALS9A
Human Chr (Location)		17q11.2; chr17:25958174-25976586 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(2) Gene trapped(12)
 

Mice homozygous for a null allele exhibit increased susceptibility to collagen-induced arthritis, increased T-helper 1 cells and decreased regulatory T cells.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	heterophilic cell-cell adhesion, positive regulation of I-kappaB kinase/NF-kappaB cascade, ...
Component	cytoplasm, extracellular region
Function	carbohydrate binding, galactoside binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (174)    Tissues (40)    Images (79)
Theiler Stages: 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	19
RNA in situ	100
Northern blot	39
Western blot	3
RT-PCR	13

cDNA source data(149)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(153) Genomic(1) cDNA(150) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000163 (Evidence)
Ensembl Gene Model	ENSMUSG00000001123 (Evidence)
Entrez Gene	16859 (Evidence)
UniGene	341434
DFCI	TC1573879, TC1599420, TC1606179
DoTS	DT.102558617, DT.493643, DT.97337126
NIA Mouse Gene Index	U033142
PDB	2D6K, 2D6L, 2D6M, 2D6N, 2D6O, 2D6P
Consensus CDS Project	CCDS25116.1, CCDS48858.1
International Mouse Knockout Project Status	Lgals9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000163	VEGA Gene Model | MGI Sequence Detail	21973	C57BL/6J
transcript	OTTMUST00000000502	VEGA | MGI Sequence Detail	1074	Not Applicable
polypeptide	OTTMUSP00000000222	VEGA | MGI Sequence Detail	352	Not Applicable

All sequences(41) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs within 2kb(108 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001079	Galectin, carbohydrate recognition domain
Protein Ontology	PR:000009776	galectin-9

References

(Earliest) J:24467 Gitt MA, et al., Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes. J Biol Chem. 1995 Mar 10;270(10):5032-8
(Latest) J:181457 Oomizu S, et al., Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner. Clin Immunol. 2012 Apr;143(1):51-8
All references(53)

Other accession IDs

MGD-MRK-24103, MGD-MRK-39495, MGI:103231, MGI:2143968, MGI:2144080, MGI:2144105