Rab33a MGI Mouse Gene Detail - MGI:109493 - RAB33A, member RAS oncogene family

Symbol

Rab33a
Name

RAB33A, member RAS oncogene family
Synonyms

Rabs10

Feature Type

protein coding gene
IDs

MGI:109493
NCBI Gene: 19337
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:47608162-47619109 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 25.68 cM
Mapping Data

1 experiment

SNPs within 2kb

223 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109493	protein coding gene	ChrX:47602540-47619112 (+)
129S1/SvImJ	ENSMUSG00200037492	protein coding gene	ChrX:31639373-31650314 (+)
A/J	ENSMUSG00195016916	protein coding gene	ChrX:34241021-34251960 (+)
AKR/J	ENSMUSG00220035217	protein coding gene	ChrX:31129436-31140381 (+)
BALB/cJ	ENSMUSG00180031330	protein coding gene	ChrX:31970916-31981855 (+)
C3H/HeJ	ENSMUSG00175037436	protein coding gene	ChrX:34989550-35000490 (+)
C57BL/6NJ	ENSMUSG00215046813	protein coding gene	ChrX:31983029-31993982 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033044	protein coding gene	ChrX:41231273-41243146 (+)
CAST/EiJ	ENSTCUG00005038676	protein coding gene	ChrX:34062637-34073580 (+)
CBA/J	ENSMUSG00210036936	protein coding gene	ChrX:32233080-32244021 (+)
DBA/2J	ENSMUSG00185033000	protein coding gene	ChrX:42939467-42950411 (+)
FVB/NJ	ENSMUSG00205028666	protein coding gene	ChrX:30918733-30929679 (+)
JF1/MsJ	ENSUMUG00000022746	protein coding gene	ChrX:61993370-62004307 (+)
LP/J	ENSMUSG00230018907	protein coding gene	ChrX:49471802-49482742 (+)
NOD/ShiLtJ	ENSMUSG00190028000	protein coding gene	ChrX:31408701-31419642 (+)
NZO/HlLtJ	ENSMUSG00225042153	protein coding gene	ChrX:54665465-54676405 (+)
PWK/PhJ	ENSLUMG00010036860	protein coding gene	ChrX:31710725-31721647 (+)
SPRET/EiJ	ENSMSPG00010023750	protein coding gene	ChrX:33295481-33306489 (+)
WSB/EiJ	ENSIUOG00005044340	protein coding gene	ChrX:32519275-32530225 (+)

Human Ortholog

RAB33A, RAB33A, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB33A, RAB33A, member RAS oncogene family
Synonyms

RabS10
Links

HGNC:9773

NCBI Gene ID: 9363

UniProt: Q14088
Chr Location

Xq26.1; chrX:130110623-130184874 (+) GRCh38

MGI Vertebrate Homology

Rab33a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB33A
Gene Tree

Rab33a

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

10
Targeted

1
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab33a

ZFIN rab33a

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All Sequences

51
RefSeq

18
UniProt

2
CCDS

CCDS30110.1

Ensembl

ENSMUSG00000031104 (Evidence)
NCBI Gene

19337

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031104	Ensembl Gene Model \| MGI Sequence Detail	10948	C57BL/6J	± kb
transcript	ENSMUST00000033430	Ensembl \| MGI Sequence Detail	1158	Not Applicable
polypeptide	ENSMUSP00000033430	Ensembl \| MGI Sequence Detail	237	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013608 Ras-related protein Rab-33A

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041822 Rab33A/B

IPR001806 Small GTPase

IPR005225 Small GTP-binding domain

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All nucleic 13

Genomic 3

cDNA 10

Microarray probesets 3

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MGD-MRK-39492

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 8
Earliest

J:39130 Zheng JY, et al., Structure and expression of the mouse S10 gene. Biochim Biophys Acta. 1997 Mar 20;1351(1-2):47-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab33a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160903	ChrX:47608122-47608158 (+)	-22 bp
Tssr160904	ChrX:47608289-47608351 (+)	158 bp
Tssr160905	ChrX:47608353-47608400 (+)	215 bp
Tssr160906	ChrX:47608401-47608415 (+)	246 bp
Tssr160907	ChrX:47608417-47608435 (+)	264 bp
Tssr160908	ChrX:47608658-47608667 (+)	501 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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