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Sms
Gene Detail
Symbol

Name
ID
Sms
spermine synthase
MGI:109490
Synonyms
SpmST
Feature Type
protein coding gene
Genetic Map
Chromosome X
72.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:157443855-157492287 bp, - strand
From VEGA annotation of GRCm38

  48433 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88709  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sms

Human
homologs
Human Homolog SMS, spermine synthase
NCBI Gene ID 6611
neXtProt AC  NX_P52788
Human Synonyms  MRSR, SPMSY, SpS, SRS
Human Chr (Location)  Xp22.1; chrX:21940573-22007213 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMS
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Radiation induced(1) Targeted(2)
Genomic Mutations involving Sms (1)
 
Male mice hemizygous for a knock-out allele exhibit muscle weakness, decreased lean body mass and bone mineral density, lumbar lordosis, postnatal growth retardation, and male infertility.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Sms interacts with 326 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process spermine biosynthetic process, spermine metabolic process
Component extracellular vesicular exosome
Function spermine synthase activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (229)    Tissues (129)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 203
Northern blot 17
RT-PCR 9
cDNA source data(104)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(113) Genomic(1) cDNA(105) Primer pair(7)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000019398 (Evidence)
Ensembl Gene ModelENSMUSG00000071708 (Evidence)
Entrez Gene20603 (Evidence)
UniGene18652
DoTSDT.531646, DT.91563650
Consensus CDS ProjectCCDS41189.1
International Mouse Knockout Project StatusSms
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019398 VEGA Gene Model | MGI Sequence Detail 48433 C57BL/6J ±  kb
transcript OTTMUST00000046291 VEGA | MGI Sequence Detail 3717 Not Applicable 
polypeptide OTTMUSP00000020908 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4)
Polymorphisms
SNPs within 2kb(240 from dbSNP Build 137)    SNPs within 2kb including multiple locations(242)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000015301 spermine synthase
References
(Earliest) J:38621 Strom TM, et al., Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet. 1997 Feb;6(2):165-71
(Latest) J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24
All references(40)
Other
accession IDs
MGD-MRK-39489, MGI:2147883

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory