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Sms Gene Detail
Summary
  • Symbol
    Sms
  • Name
    spermine synthase
  • Synonyms
    SpmST
  • Feature Type
    protein coding gene
  • IDs
    MGI:109490
    NCBI Gene: 20603
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:156226851-156275283 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 72.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1243 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109490
 protein coding gene ChrX:156226847-156275283 (-)
129S1/SvImJ ENSMUSG00200024799
 protein coding gene ChrX:132971557-133019995 (-)
A/J ENSMUSG00195037933
 protein coding gene ChrX:138066545-138115230 (-)
A/J ENSMUSG00195008999
 protein coding gene ChrX:47595740-47597413 (-)
AKR/J ENSMUSG00220028857
 protein coding gene ChrX:129911353-129959791 (-)
BALB/cJ ENSMUSG00180038700
 protein coding gene ChrX:133432831-133481267 (-)
BALB/cJ ENSMUSG00180006497
 protein coding gene ChrX:44216808-44218481 (-)
C3H/HeJ ENSMUSG00175026516
 protein coding gene ChrX:138004018-138052451 (-)
C3H/HeJ ENSMUSG00175009202
 protein coding gene ChrX:47776887-47778560 (-)
C57BL/6NJ ENSMUSG00215017751
 protein coding gene ChrX:133801831-133850263 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033523
 protein coding gene ChrX:146006382-146056665 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033288
 protein coding gene ChrX:135312417-135360854 (-)
DBA/2J ENSMUSG00185034245
 protein coding gene ChrX:56864500-56866173 (-)
DBA/2J ENSMUSG00185041337
 protein coding gene ChrX:150273233-150321671 (-)
FVB/NJ ENSMUSG00205022326
 protein coding gene ChrX:133922624-133971060 (-)
JF1/MsJ ENSUMUG00000024818
 protein coding gene ChrX:170682415-170731317 (-)
LP/J ENSMUSG00230018445
 protein coding gene ChrX:63421396-63423069 (-)
LP/J ENSMUSG00230012497
 protein coding gene ChrX:157056478-157104909 (-)
NOD/ShiLtJ ENSMUSG00190031066
 protein coding gene ChrX:134445497-134494192 (-)
NZO/HlLtJ ENSMUSG00225032117
 protein coding gene ChrX:68667056-68668729 (-)
NZO/HlLtJ ENSMUSG00225041886
 protein coding gene ChrX:160462587-160511270 (-)
PWK/PhJ ENSLUMG00010033693
 protein coding gene ChrX:131789695-131838502 (-)
SPRET/EiJ ENSMSPG00010017419
 protein coding gene ChrX:136894774-136943390 (-)
WSB/EiJ ENSIUOG00005025538
 protein coding gene ChrX:134785340-134834132 (-)



Homology
more
  • Human Ortholog
    SMS, spermine synthase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMS, spermine synthase
  • Synonyms
    MRSR, MRXSSR, SPMSY, SpS, SRS
  • Links
    NCBI Gene ID: 6611
    UniProt: P52788

  • Chr Location
    Xp22.11; chrX:21940709-21994837 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SMS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 3 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele exhibit muscle weakness, decreased lean body mass and bone mineral density, lumbar lordosis, postnatal growth retardation, and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    129
  • cDNA Data
    105
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071708 Ensembl Gene Model | MGI Sequence Detail 48433 C57BL/6J ±  kb
    transcript ENSMUST00000112529 Ensembl | MGI Sequence Detail 3717 Not Applicable  
    polypeptide ENSMUSP00000108148 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015301 spermine synthase
      (term hierarchy)
    • EC
      2.5.1.22
    • InterPro Domains
      IPR030374 Polyamine biosynthesis domain
      IPR030373 Polyamine biosynthesis domain, conserved site
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR035246 Spermidine synthase, tetramerisation domain
      IPR037163 Spermidine synthase, tetramerisation domain superfamily
      IPR015576 Spermine synthase, animal
      IPR040900 Spermine synthase, N-terminal
    • GlyGen
      P97355 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 1
      cDNA 106
      Primer pair 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-39489, MGI:2147883
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 13
      Phenotypes 42
    • Earliest
      J:28887 Carter TC, et al., The genetic sensitivity to X-rays of mouse foetal gonads. Genet Res. 1960;1(3):351-5
    • Latest
      J:359503 Yorgan TA, et al., Inactivation of spermine synthase in mice causes osteopenia due to reduced osteoblast activity. J Bone Miner Res. 2024 Oct 29;39(11):1606-1620
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory