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Sms Gene Detail
Summary
  • Symbol
    Sms
  • Name
    spermine synthase
  • Synonyms
    SpmST
  • Feature Type
    protein coding gene
  • IDs
    MGI:109490
    NCBI Gene: 20603
  • Gene Overview
    MyGene.info: SMS
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:157443852-157492046 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 72.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109490
protein coding gene ChrX:157443852-157492287 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036217
protein coding gene ChrX:155332159-155384386 (-)
A/J MGP_AJ_G0036187
protein coding gene ChrX:154650937-154700420 (-)
AKR/J MGP_AKRJ_G0036115
protein coding gene ChrX:159518367-159566633 (-)
BALB/cJ MGP_BALBcJ_G0036180
protein coding gene ChrX:152706799-152758336 (-)
C3H/HeJ MGP_C3HHeJ_G0035886
protein coding gene ChrX:155689179-155743460 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036702
protein coding gene ChrX:159912974-159961858 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033523
protein coding gene ChrX:146006382-146056665 (-)
CAST/EiJ MGP_CASTEiJ_G0035174
protein coding gene ChrX:134787055-134836051 (-)
CBA/J MGP_CBAJ_G0035861
protein coding gene ChrX:164479870-164535452 (-)
DBA/2J MGP_DBA2J_G0036027
protein coding gene ChrX:153627818-153676900 (-)
FVB/NJ MGP_FVBNJ_G0035958
protein coding gene ChrX:152716258-152765173 (-)
LP/J MGP_LPJ_G0036112
protein coding gene ChrX:156494141-156550220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035990
protein coding gene ChrX:173057951-173108871 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036743
protein coding gene ChrX:154882582-154934732 (-)
PWK/PhJ MGP_PWKPhJ_G0034872
protein coding gene ChrX:131744623-131795632 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034693
protein coding gene ChrX:135258252-135307918 (-)
WSB/EiJ MGP_WSBEiJ_G0035309
protein coding gene ChrX:152879122-152930157 (-)



Homology
more
  • Human Ortholog
    SMS, spermine synthase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SMS, spermine synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRSR, SPMSY, SpS, SRS
  • Links
    NCBI Gene ID: 6611
    neXtProt AC: NX_P52788
    UniProt: P52788

  • Chr Location
    Xp22.11; chrX:21940573-21994837 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 88709
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMS
  • Gene Tree
    Sms
Human Diseases
more
  • Diseases
    1 with human SMS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele exhibit muscle weakness, decreased lean body mass and bone mineral density, lumbar lordosis, postnatal growth retardation, and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20603 NCBI Gene Model | MGI Sequence Detail 48195 C57BL/6J ±  kb
    transcript NM_009214 RefSeq | MGI Sequence Detail 3721 C57BL/6  
    polypeptide NP_033240 RefSeq | MGI Sequence Detail 366 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 1
      cDNA 106
      Primer pair 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-39489, MGI:2147883
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 3
      Phenotypes 32
    • Earliest
      J:28887 Carter TC, et al., The genetic sensitivity to X-rays of mouse foetal gonads. Genet Res. 1960;1:351-5
    • Latest
      J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory