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Prdx2
Gene Detail
Symbol

Name
ID
Prdx2
peroxiredoxin 2
MGI:109486
Synonyms
protector protein, PRP, PrxII, Prx II-1, Tdpx1, TDX1, thiol specific antioxidant protein, thioredoxin dependent peroxide reductase 1, thioredoxin peroxidase, thioredoxin reductase, TPx, TR, Trx dependent peroxide reductase 1, TSA
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:84969587-84974834 bp, + strand
From VEGA annotation of GRCm38

  5248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRDX2
Protein SuperFamily: AHPC
Gene Tree: Prdx2

Human
homologs
PRDX2, peroxiredoxin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7001
neXtProt AC: NX_P32119

Human Synonyms: HEL-S-2a, NKEFB, NKEF-B, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA

Human Chr (Location): 19p13.2; chr19:12796820-12801910 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have hemolytic anemia and exhibit enlarged spleens due to congestion of the red pulp.
 
Interactions
Prdx2 interacts with 101 markers (Mir19a, Mir29b-2, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process activation of MAPK activity, cellular response to oxidative stress, ...
Component cytoplasm, cytosol, ...
Function antioxidant activity, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (182)    Tissues (167)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
Northern blot 16
Western blot 2
RT-PCR 56
cDNA source data(573)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prdx2 ; ZFIN prdx2    NEW 
Molecular
reagents
All nucleic(584) Genomic(2) cDNA(576) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016959 (Evidence)
Ensembl Gene Model ENSMUSG00000005161 (Evidence)
Entrez Gene 21672 (Evidence)
UniGene 347009
DFCI TC1573827
DoTS DT.496904, DT.101318011, DT.101291469, DT.91294835
NIA Mouse Gene Index U136056, U021643
EC 1.11.1.15
Consensus CDS Project CCDS40416.1
International Mouse Phenotyping Consortium Status Prdx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016959 VEGA Gene Model | MGI Sequence Detail 5248 C57BL/6J ±  kb
transcript OTTMUST00000041123 VEGA | MGI Sequence Detail 1612 Not Applicable 
polypeptide OTTMUSP00000018423 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
InterPro IPR024706 Peroxiredoxin, AhpC-type
InterPro IPR019479 Peroxiredoxin, C-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000013192 peroxiredoxin-2
References
(Earliest) J:39372 Ichimiya S, et al., Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 1997 Mar;16(3):311-21
(Latest) J:220104 Matte A, et al., The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence. Free Radic Biol Med. 2014 Nov;76:80-8
All references(73)
Other
accession IDs
MGD-MRK-39485, MGI:2138384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory