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Prdx2 Gene Detail
Summary
  • Symbol
    Prdx2
  • Name
    peroxiredoxin 2
  • Synonyms
    protector protein, PRP, PrxII, Prx II-1, Tdpx1, TDX1, thiol specific antioxidant protein, thioredoxin dependent peroxide reductase 1, thioredoxin peroxidase, thioredoxin reductase, TPx, TR, Trx dependent peroxide reductase 1, TSA
  • Feature Type
    protein coding gene
  • IDs
    MGI:109486
    NCBI Gene: 21672
  • Gene Overview
    MyGene.info: PRDX2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84969622-84974811 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.40 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109486
protein coding gene Chr8:84969587-84974834 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033883
protein coding gene Chr8:85912376-85918841 (+)
A/J MGP_AJ_G0033866
protein coding gene Chr8:82517348-82522532 (+)
AKR/J MGP_AKRJ_G0033792
protein coding gene Chr8:84961106-84966291 (+)
BALB/cJ MGP_BALBcJ_G0033859
protein coding gene Chr8:82649023-82654208 (+)
C3H/HeJ MGP_C3HHeJ_G0033569
protein coding gene Chr8:85587932-85593168 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034379
protein coding gene Chr8:89198294-89203541 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031320
protein coding gene Chr8:76316074-76321461 (+)
CAST/EiJ MGP_CASTEiJ_G0032899
protein coding gene Chr8:85018860-85024128 (+)
CBA/J MGP_CBAJ_G0033545
protein coding gene Chr8:92215770-92221225 (+)
DBA/2J MGP_DBA2J_G0033698
protein coding gene Chr8:82156779-82162356 (+)
FVB/NJ MGP_FVBNJ_G0033646
protein coding gene Chr8:81111428-81116612 (+)
LP/J MGP_LPJ_G0033790
protein coding gene Chr8:86013605-86019644 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033688
protein coding gene Chr8:94790719-94797084 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034396
protein coding gene Chr8:84950984-84956231 (+)
PWK/PhJ MGP_PWKPhJ_G0032603
protein coding gene Chr8:81403870-81409344 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032439
protein coding gene Chr8:83762432-83767884 (+)
WSB/EiJ MGP_WSBEiJ_G0033012
protein coding gene Chr8:85384934-85390119 (+)



Homology
more
  • Human Ortholog
    PRDX2, peroxiredoxin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRDX2, peroxiredoxin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-2a, NKEFB, NKEF-B, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
  • Links
    NCBI Gene ID: 7001
    neXtProt AC: NX_P32119
    UniProt: P32119

  • Chr Location
    19p13.13; chr19:12796820-12801910 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21182
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRDX2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have hemolytic anemia and exhibit enlarged spleens due to congestion of the red pulp.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21672 NCBI Gene Model | MGI Sequence Detail 5190 C57BL/6J ±  kb
    transcript NM_011563 RefSeq | MGI Sequence Detail 1481 C57BL/6  
    polypeptide Q61171 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 586
      Genomic 2
      cDNA 577
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39485, MGI:2138384
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 13
      Gene Ontology 18
      Phenotypes 54
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory