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Prdx2
Gene Detail
 Symbol
Name
ID
Prdx2
peroxiredoxin 2
MGI:109486
Synonyms protector protein, PRP, PrxII, Prx II-1, Tdpx1, TDX1, thiol specific antioxidant protein, thioredoxin dependent peroxide reductase 1, thioredoxin peroxidase, thioredoxin reductase, TPx, TR, Trx dependent peroxide reductase 1, TSA
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:84969587-84974834 bp, + strand
From VEGA annotation of GRCm38

  5248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: AHPC
Gene Tree: Prdx2

Human
homologs
Human Homolog PRDX2, peroxiredoxin 2
NCBI Gene ID 7001
neXtProt AC  NX_P32119
Human Synonyms  HEL-S-2a, NKEFB, NKEF-B, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
Human Chr (Location)  19p13.2; chr19:12796820-12801910 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have hemolytic anemia and exhibit enlarged spleens due to congestion of the red pulp.
 
Interactions
Prdx2 interacts with 102 markers (Mir19a, Mir29b-2, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process activation of MAPK activity, cellular response to oxidative stress, ...
Component cytoplasm, cytosol, ...
Function antioxidant activity, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (182)    Tissues (167)    Images (18)
Theiler Stages: 10, 11, 12, 14, 16, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 108
Northern blot 16
Western blot 2
RT-PCR 56
cDNA source data(573)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(584) Genomic(2) cDNA(576) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016959 (Evidence)
Ensembl Gene ModelENSMUSG00000005161 (Evidence)
Entrez Gene21672 (Evidence)
UniGene347009
DFCITC1573827
DoTSDT.101291469, DT.101318011, DT.496904, DT.91294835
NIA Mouse Gene IndexU021643, U136056
EC1.11.1.15
Consensus CDS ProjectCCDS40416.1
International Mouse Knockout Project StatusPrdx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016959 VEGA Gene Model | MGI Sequence Detail 5248 C57BL/6J ±  kb
transcript OTTMUST00000041123 VEGA | MGI Sequence Detail 1612 Not Applicable 
polypeptide OTTMUSP00000018423 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
InterPro IPR024706 Peroxiredoxin, AhpC-type
InterPro IPR019479 Peroxiredoxin, C-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000013192 peroxiredoxin-2
References (Earliest) J:39372 Ichimiya S, et al., Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 1997 Mar;16(3):311-21
(Latest) J:206260 Won HY, et al., Ablation of peroxiredoxin II attenuates experimental colitis by increasing FoxO1-induced Foxp3+ regulatory T cells. J Immunol. 2013 Oct 15;191(8):4029-37
All references(70)
Other
accession IDs
MGD-MRK-39485, MGI:2138384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory