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Prdx2 Gene Detail
Summary
  • Symbol
    Prdx2
  • Name
    peroxiredoxin 2
  • Synonyms
    protector protein, PRP, PrxII, Prx II-1, Tdpx1, TDX1, thiol specific antioxidant protein, thioredoxin dependent peroxide reductase 1, thioredoxin peroxidase, thioredoxin reductase, TPx, TR, Trx dependent peroxide reductase 1, TSA
  • Feature Type
    protein coding gene
  • IDs
    MGI:109486
    NCBI Gene: 21672
  • Gene Overview
    MyGene.info: PRDX2
Location & Maps
more
  • Sequence Map
    Chr8:84969587-84974834 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5248 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.40 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRDX2, peroxiredoxin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRDX2, peroxiredoxin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-2a, NKEFB, NKEF-B, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
  • Links
    NCBI Gene ID: 7001
    neXtProt AC: NX_P32119

  • Chr Location
    19p13.2; chr19:12796820-12801910 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21182
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PRDX2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Gene trapped
    26
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Prdx2
  • Incidental Mutations
Homozygous null mice have hemolytic anemia and exhibit enlarged spleens due to congestion of the red pulp.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016959 VEGA Gene Model | MGI Sequence Detail 5248 C57BL/6J ±  kb
transcript OTTMUST00000041123 VEGA | MGI Sequence Detail 1612 Not Applicable  
polypeptide OTTMUSP00000018423 VEGA | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    114 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 584
    Genomic 2
    cDNA 576
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-39485, MGI:2138384
References
more
  • Summaries
    All 73
    Developmental Gene Expression 12
    Gene Ontology 16
    Phenotypes 52
  • Earliest
    J:39372 Ichimiya S, et al., Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 1997 Mar;16(3):311-21
  • Latest
    J:227089 Pirson M, et al., Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. J Comp Neurol. 2015 Dec 1;523(17):2599-617

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory