Prdx2 MGI Mouse Gene Detail - MGI:109486

Symbol

Prdx2
Name

peroxiredoxin 2
Synonyms

protector protein, PRP, PrxII, Prx II-1, Tdpx1, TDX1, thiol specific antioxidant protein, thioredoxin dependent peroxide reductase 1, thioredoxin peroxidase, thioredoxin reductase, TPx, TR, Trx dependent peroxide reductase 1, TSA

Feature Type

protein coding gene
IDs

MGI:109486
NCBI Gene: 21672
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr8:85696251-85701440 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.40 cM
Mapping Data

4 experiments

SNPs within 2kb

113 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109486	protein coding gene	Chr8:85696216-85701463 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033883	protein coding gene	Chr8:85912376-85918841 (+)
A/J	MGP_AJ_G0033866	protein coding gene	Chr8:82517348-82522532 (+)
AKR/J	MGP_AKRJ_G0033792	protein coding gene	Chr8:84961106-84966291 (+)
BALB/cJ	MGP_BALBcJ_G0033859	protein coding gene	Chr8:82649023-82654208 (+)
C3H/HeJ	MGP_C3HHeJ_G0033569	protein coding gene	Chr8:85587932-85593168 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034379	protein coding gene	Chr8:89198294-89203541 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031320	protein coding gene	Chr8:76316074-76321461 (+)
CAST/EiJ	MGP_CASTEiJ_G0032899	protein coding gene	Chr8:85018860-85024128 (+)
CBA/J	MGP_CBAJ_G0033545	protein coding gene	Chr8:92215770-92221225 (+)
DBA/2J	MGP_DBA2J_G0033698	protein coding gene	Chr8:82156779-82162356 (+)
FVB/NJ	MGP_FVBNJ_G0033646	protein coding gene	Chr8:81111428-81116612 (+)
LP/J	MGP_LPJ_G0033790	protein coding gene	Chr8:86013605-86019644 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033688	protein coding gene	Chr8:94790719-94797084 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034396	protein coding gene	Chr8:84950984-84956231 (+)
PWK/PhJ	MGP_PWKPhJ_G0032603	protein coding gene	Chr8:81403870-81409344 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032439	protein coding gene	Chr8:83762432-83767884 (+)
WSB/EiJ	MGP_WSBEiJ_G0033012	protein coding gene	Chr8:85384934-85390119 (+)

Human Ortholog

PRDX2, peroxiredoxin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRDX2, peroxiredoxin 2
Synonyms

HEL-S-2a, NKEFB, NKEF-B, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
Links

HGNC:9353

NCBI Gene ID: 7001

neXtProt AC: NX_P32119

UniProt: P32119
Chr Location

19p13.13; chr19:12796820-12801800 (-) GRCh38

MGI Vertebrate Homology

Prdx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRDX2
Protein SuperFamily

AHPC
Gene Tree

Prdx2

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
79 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

24
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Prdx2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have hemolytic anemia and exhibit enlarged spleens due to congestion of the red pulp.

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All GO Annotations

42
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

944
Tissues

202
cDNA Data

574
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prdx2

ZFIN prdx2

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All Sequences

60
RefSeq

4
UniProt

3
CCDS

CCDS40416.1

Ensembl

ENSMUSG00000005161 (Evidence)
NCBI Gene

21672

			Length	Strain/Species	Flank
genomic	21672	NCBI Gene Model \| MGI Sequence Detail	5190	C57BL/6J	± kb
transcript	NM_011563	RefSeq \| MGI Sequence Detail	1481	ZRU/MplStud
polypeptide	Q61171	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013192 peroxiredoxin-2

(term hierarchy)
EC

1.11.1.24
InterPro Domains

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

IPR024706 Peroxiredoxin, AhpC-type

IPR019479 Peroxiredoxin, C-terminal

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily

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All nucleic 587

Genomic 2

cDNA 577

Primer pair 7

Other 1

Microarray probesets 5

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MGD-MRK-39485, MGI:2138384

Summaries

All 137

Developmental Gene Expression 16

Gene Ontology 15

Phenotypes 79
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:344186 Munoz-Gallardo MDM, et al., miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810

TSS for Prdx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78481	Chr8:85695596-85695610 (+)	-648 bp
Tssr78482	Chr8:85696247-85696265 (+)	5 bp
Tssr78483	Chr8:85696266-85696282 (+)	23 bp
Tssr78484	Chr8:85696285-85696308 (+)	46 bp
Tssr78485	Chr8:85696315-85696335 (+)	74 bp
Tssr2631	Chr8:85696337-85696344 (+)	90 bp
Tssr78486	Chr8:85696419-85696447 (+)	182 bp
Tssr78487	Chr8:85696453-85696491 (+)	221 bp
Tssr78488	Chr8:85696697-85696722 (+)	459 bp
Tssr78489	Chr8:85697856-85697872 (+)	1,613 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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