About   Help   FAQ
Wnt8b Gene Detail
Summary
  • Symbol
    Wnt8b
  • Name
    wingless-type MMTV integration site family, member 8B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109485
    NCBI Gene: 22423
  • Gene Overview
    MyGene.info: WNT8B
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:44493472-44514273 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 37.98 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    279 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109485
protein coding gene Chr19:44493472-44514273 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025171
protein coding gene Chr19:43989146-44012953 (+)
A/J MGP_AJ_G0025148
protein coding gene Chr19:41883325-41905023 (+)
AKR/J MGP_AKRJ_G0025116
protein coding gene Chr19:43230954-43254091 (+)
BALB/cJ MGP_BALBcJ_G0025142
protein coding gene Chr19:41934142-41955185 (+)
C3H/HeJ MGP_C3HHeJ_G0024902
protein coding gene Chr19:43386164-43408323 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025585
protein coding gene Chr19:45071578-45094729 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022999
protein coding gene Chr19:41157058-41177617 (+)
CAST/EiJ MGP_CASTEiJ_G0024367
protein coding gene Chr19:43105943-43131773 (+)
CBA/J MGP_CBAJ_G0024882
protein coding gene Chr19:47342770-47363317 (+)
DBA/2J MGP_DBA2J_G0025014
protein coding gene Chr19:41702571-41723014 (+)
FVB/NJ MGP_FVBNJ_G0024975
protein coding gene Chr19:41472621-41492849 (+)
LP/J MGP_LPJ_G0025100
protein coding gene Chr19:43927555-43951227 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025006
protein coding gene Chr19:46780079-46802520 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025643
protein coding gene Chr19:43301547-43324508 (+)
PWK/PhJ MGP_PWKPhJ_G0024116
protein coding gene Chr19:41596624-41618141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023920
protein coding gene Chr19:41993470-42013792 (+)
WSB/EiJ MGP_WSBEiJ_G0024437
protein coding gene Chr19:43428093-43452276 (+)



Homology
more
  • Human Ortholog
    WNT8B, Wnt family member 8B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT8B, Wnt family member 8B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 7479
    neXtProt AC: NX_Q93098
    UniProt: Q93098

  • Chr Location
    10q24.31; chr10:100463055-100483642 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22423 NCBI Gene Model | MGI Sequence Detail 20802 C57BL/6J ±  kb
transcript NM_011720 RefSeq | MGI Sequence Detail 3376 C57BL/6  
polypeptide Q9WUD6 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 25
    Primer pair 10
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39484
References
more
  • Summaries
    All 133
    Developmental Gene Expression 106
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
  • Latest
    J:254118 De Clercq S, et al., DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 Feb 1;28(2):493-509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory