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Wnt8b
Gene Detail
Symbol

Name
ID
Wnt8b
wingless-type MMTV integration site family, member 8B
MGI:109485
Feature Type
protein coding gene
Genetic Map
Chromosome 19
37.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:44493472-44514273 bp, + strand
From NCBI annotation of GRCm38

  20802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT8B
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt8b

Human
homologs
WNT8B, wingless-type MMTV integration site family, member 8B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7479
neXtProt AC: NX_Q93098

Human Chr (Location): 10q24; chr10:100463055-100483642 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.
 
Interactions
Wnt8b interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell-cell signaling, cell fate commitment, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, receptor binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (89 records)
Data Summary: Results (345)    Tissues (307)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 333
RT-PCR 12
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT8B ; Xenbase wnt8b ; ZFIN wnt8b    NEW 
Molecular
reagents
All nucleic(36) cDNA(24) Primer pair(9) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000036961 (Evidence)
Entrez Gene 22423 (Evidence)
UniGene 88365
DFCI TC1587932
DoTS DT.486231
NIA Mouse Gene Index U019488
Consensus CDS Project CCDS50446.1
International Mouse Phenotyping Consortium Status Wnt8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22423 NCBI Gene Model | MGI Sequence Detail 20802 C57BL/6J ±  kb
transcript NM_011720 RefSeq | MGI Sequence Detail 3376 C57BL/6 
polypeptide Q9WUD6 UniProt | EBI | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013301 Wnt-8 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017451 protein Wnt-8b
Graphical View of Protein Domain Structure
References
(Earliest) J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
(Latest) J:217604 Lavado A, et al., The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development. 2014 Nov;141(21):4182-93
All references(115)
Other
accession IDs
MGD-MRK-39484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory