Wnt8b Gene Detail

Summary

• Symbol
  Wnt8b
• Name
  wingless-type MMTV integration site family, member 8B

• Feature Type
  protein coding gene
• IDs
  MGI:109485
  NCBI Gene: 22423
• Gene Overview
  MyGene.info: WNT8B
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr19:44493472-44514273 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 37.98 cM
• Mapping Data
  7 experiments

Strain
Comparison

• SNPs within 2kb
  279 from dbSNP Build 142
• Strain Annotations
  18
• PCR
  1
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109485	protein coding gene	Chr19:44493472-44514273 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025171	protein coding gene	Chr19:43989146-44012953 (+)
A/J	MGP_AJ_G0025148	protein coding gene	Chr19:41883325-41905023 (+)
AKR/J	MGP_AKRJ_G0025116	protein coding gene	Chr19:43230954-43254091 (+)
BALB/cJ	MGP_BALBcJ_G0025142	protein coding gene	Chr19:41934142-41955185 (+)
C3H/HeJ	MGP_C3HHeJ_G0024902	protein coding gene	Chr19:43386164-43408323 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025585	protein coding gene	Chr19:45071578-45094729 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022999	protein coding gene	Chr19:41157058-41177617 (+)
CAST/EiJ	MGP_CASTEiJ_G0024367	protein coding gene	Chr19:43105943-43131773 (+)
CBA/J	MGP_CBAJ_G0024882	protein coding gene	Chr19:47342770-47363317 (+)
DBA/2J	MGP_DBA2J_G0025014	protein coding gene	Chr19:41702571-41723014 (+)
FVB/NJ	MGP_FVBNJ_G0024975	protein coding gene	Chr19:41472621-41492849 (+)
LP/J	MGP_LPJ_G0025100	protein coding gene	Chr19:43927555-43951227 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025006	protein coding gene	Chr19:46780079-46802520 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025643	protein coding gene	Chr19:43301547-43324508 (+)
PWK/PhJ	MGP_PWKPhJ_G0024116	protein coding gene	Chr19:41596624-41618141 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023920	protein coding gene	Chr19:41993470-42013792 (+)
WSB/EiJ	MGP_WSBEiJ_G0024437	protein coding gene	Chr19:43428093-43452276 (+)

Homology

• Human Ortholog
  WNT8B, Wnt family member 8B

• Vertebrate Orthologs
  10

• Human Ortholog
  WNT8B, Wnt family member 8B
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:12789

  NCBI Gene ID: 7479

  neXtProt AC: NX_Q93098

  UniProt: Q93098

  
  
• Chr Location
  10q24.31; chr10:100463055-100483642 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 2550
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: WNT8B
• Protein SuperFamily
  int-1 transforming protein
• Gene Tree
  Wnt8b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  10 strains or lines available

Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  17
• GO References
  6

• External Resources
  FuncBase

Expression

• Assay Results
  365
• Tissues
  322
• cDNA Data
  22
• Literature Summary
  113

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA WNT8B
  Xenbase wnt8b
  ZFIN wnt8b

Interactions

• Wnt8b interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  35
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS50446.1
• UniGene
  88365

• Ensembl
  ENSMUSG00000036961 (Evidence)
• NCBI Gene
  22423

Representative Sequences			Length	Strain/Species
genomic	22423	NCBI Gene Model | MGI Sequence Detail	20802	C57BL/6J
transcript	NM_011720	RefSeq | MGI Sequence Detail	3376	C57BL/6
polypeptide	Q9WUD6	UniProt | EBI | MGI Sequence Detail	350	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000017451 protein Wnt-8b
  (term hierarchy)
• InterPro Domains
  IPR034311 Protein Wnt-8B
  IPR005817 Wnt
  IPR013301 Wnt-8 protein
  IPR018161 Wnt protein, conserved site

Molecular
Reagents

• All nucleic 40

  cDNA 25

  Primer pair 10

  Other 5

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-39484

References

• Summaries
  All 140

  Developmental Gene Expression 113

  Gene Ontology 6

  Phenotypes 3
• Earliest
  J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
• Latest
  J:273296 Kaiser K, et al., WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nat Commun. 2019 Apr 2;10(1):1498

TSS for Wnt8b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156615	Chr19:44493467-44493500 (+)	12 bp
Tssr156616	Chr19:44511197-44511208 (+)	17,731 bp
Tssr156617	Chr19:44511232-44511242 (+)	17,765 bp