Wnt8b
Gene Detail

Symbol Name ID

Wnt8b wingless-type MMTV integration site family, member 8B MGI:109485

Feature Type

protein coding gene

Genetic Map

Chromosome 19

37.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:44493472-44514273 bp, + strand From NCBI annotation of GRCm38   20802 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt8b

Human homologs

Human Homolog		WNT8B, wingless-type MMTV integration site family, member 8B
NCBI Gene ID		7479
neXtProt AC		NX_Q93098
Human Chr (Location)		10q24; chr10:100463055-100483642 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.

 

Interactions

Wnt8b interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell-cell signaling, cell fate commitment, ...
Component	extracellular region, extracellular space, ...
Function	frizzled binding, receptor binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (85 records)

Data Summary: Results (347)    Tissues (303)    Images (38)
Theiler Stages: 4, 5, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	333
RT-PCR	14

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(36) cDNA(24) Primer pair(9) Other(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000036961 (Evidence)
Entrez Gene	22423 (Evidence)
UniGene	88365
DFCI	TC1587932
DoTS	DT.486231
NIA Mouse Gene Index	U019488
Consensus CDS Project	CCDS50446.1
International Mouse Knockout Project Status	Wnt8b

Sequences

Length	Strain/Species
genomic	22423	NCBI Gene Model | MGI Sequence Detail	20802	C57BL/6J
transcript	NM_011720	RefSeq | MGI Sequence Detail	3376	C57BL/6
polypeptide	Q9WUD6	UniProt | EBI | MGI Sequence Detail	350	Not Applicable

All sequences(19) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(282 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013301	Wnt-8 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017451	protein Wnt-8b

Graphical View of Protein Domain Structure

References

(Earliest) J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(112)

Other accession IDs

MGD-MRK-39484