About   Help   FAQ
Wnt8b
Gene Detail
 Symbol
Name
ID
Wnt8b
wingless-type MMTV integration site family, member 8B
MGI:109485
Feature Type protein coding gene
Genetic Map
Chromosome 19
37.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:44493472-44514273 bp, + strand
From NCBI annotation of GRCm38

  20802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt8b

Human
homologs
Human Homolog WNT8B, wingless-type MMTV integration site family, member 8B
NCBI Gene ID 7479
neXtProt AC  NX_Q93098
Human Chr (Location)  10q24; chr10:100463055-100483642 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.
 
Interactions
Wnt8b interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell-cell signaling, cell fate commitment, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, receptor binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (345)    Tissues (301)    Images (38)
Theiler Stages: 3, 5, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 333
RT-PCR 12
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(24) Primer pair(9) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000036961 (Evidence)
Entrez Gene22423 (Evidence)
UniGene88365
DFCITC1587932
DoTSDT.486231
NIA Mouse Gene IndexU019488
Consensus CDS ProjectCCDS50446.1
International Mouse Knockout Project StatusWnt8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22423 NCBI Gene Model | MGI Sequence Detail 20802 C57BL/6J ±  kb
transcript NM_011720 RefSeq | MGI Sequence Detail 3376 C57BL/6 
polypeptide Q9WUD6 UniProt | EBI | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013301 Wnt-8 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017451 protein Wnt-8b
Graphical View of Protein Domain Structure
References (Earliest) J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(112)
Other
accession IDs
MGD-MRK-39484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory