Wnt8b MGI Mouse Gene Detail - MGI:109485 - wingless-type MMTV integration site family, member 8B

Wnt8b Gene Detail

Symbol

Wnt8b
Name

wingless-type MMTV integration site family, member 8B

Feature Type

protein coding gene
IDs

MGI:109485
NCBI Gene: 22423
Gene Overview

MyGene.info: WNT8B

Sequence Map

Chr19:44493472-44514273 bp, + strand
From NCBI annotation of GRCm38

Mouse Genome Browser
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Sequence

20802 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 37.98 cM
Mapping Data

7 experiments

Human Ortholog

WNT8B, Wnt family member 8B

Vertebrate Orthologs

10

Human Ortholog

WNT8B, Wnt family member 8B
Orthology source: HomoloGene, HGNC
Links

HGNC:12789

NCBI Gene ID: 7479

neXtProt AC: NX_Q93098
Chr Location

10q24; chr10:100463055-100483642 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2550
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: WNT8B
Protein SuperFamily

int-1 transforming protein
Gene Tree

Wnt8b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
2 phenotype references

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.

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All GO Annotations

16
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

345
Tissues

307
cDNA Data

21
Literature Summary

95

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

GEISHA WNT8B

Xenbase wnt8b

ZFIN wnt8b

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Wnt8b interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

16
RefSeq

2
UniProt

4
CCDS

CCDS50446.1
UniGene

88365

Ensembl

ENSMUSG00000036961 (Evidence)
NCBI Gene

22423

			Length	Strain/Species	Flank
genomic	22423	NCBI Gene Model \| MGI Sequence Detail	20802	C57BL/6J	± kb
transcript	NM_011720	RefSeq \| MGI Sequence Detail	3376	C57BL/6
polypeptide	Q9WUD6	UniProt \| EBI \| MGI Sequence Detail	350	Not Applicable

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SNPs within 2kb

279 from dbSNP Build 142

PCR

1
RFLP

2

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UniProt

4 Sequences
Protein Ontology

PR:000017451 protein Wnt-8b
InterPro Domains

IPR005817 Wnt

IPR013301 Wnt-8 protein

IPR018161 Wnt protein, conserved site

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All nucleic 36

cDNA 24

Primer pair 9

Other 3

Microarray probesets 3

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MGD-MRK-39484

Summaries

All 119

Developmental Gene Expression 95

Gene Ontology 5

Phenotypes 2
Earliest

J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
Latest

J:232481 Caronia-Brown G, et al., Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development. Neural Dev. 2016;11:9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2016 MGI 6.05