Wnt8b Gene Detail

Summary

• Symbol
  Wnt8b
• Name
  wingless-type MMTV integration site family, member 8B

• Feature Type
  protein coding gene
• IDs
  MGI:109485
  NCBI Gene: 22423
• Gene Overview
  MyGene.info: WNT8B

Location & Maps

• Sequence Map
  Chr19:44493472-44514273 bp, + strand
• From NCBI annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    20802 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 37.98 cM
• Mapping Data
  7 experiments

Homology

• Human Ortholog
  WNT8B, Wnt family member 8B

• Vertebrate Orthologs
  10

• Human Ortholog
  WNT8B, Wnt family member 8B
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:12789

  NCBI Gene ID: 7479

  neXtProt AC: NX_Q93098

  UniProt: Q93098

  
  
• Chr Location
  10q24.31; chr10:100463055-100483642 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 2550
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: WNT8B
• Protein SuperFamily
  int-1 transforming protein
• Gene Tree
  Wnt8b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  7 strains or lines available

Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  5

• External Resources
  FuncBase

Expression

• Assay Results
  348
• Tissues
  310
• cDNA Data
  21
• Literature Summary
  97

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA WNT8B
  Xenbase wnt8b
  ZFIN wnt8b

Interactions

• Wnt8b interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  16
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS50446.1
• UniGene
  88365

• Ensembl
  ENSMUSG00000036961 (Evidence)
• NCBI Gene
  22423

Representative Sequences			Length	Strain/Species
genomic	22423	NCBI Gene Model | MGI Sequence Detail	20802	C57BL/6J
transcript	NM_011720	RefSeq | MGI Sequence Detail	3376	C57BL/6
polypeptide	Q9WUD6	UniProt | EBI | MGI Sequence Detail	350	Not Applicable

Polymorphisms

• SNPs within 2kb
  279 from dbSNP Build 142

• PCR
  1
• RFLP
  2

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000017451 protein Wnt-8b
  (term hierarchy)
• InterPro Domains
  IPR034311 Protein Wnt-8B
  IPR005817 Wnt
  IPR013301 Wnt-8 protein
  IPR018161 Wnt protein, conserved site

Molecular
Reagents

• All nucleic 37

  cDNA 24

  Primer pair 10

  Other 3

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-39484

References

• Summaries
  All 121

  Developmental Gene Expression 97

  Gene Ontology 5

  Phenotypes 2
• Earliest
  J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
• Latest
  J:239682 Wilde JJ, et al., Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci. 2017 Mar 08;37(10):2565-2579