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Rnf103 Gene Detail
Summary
  • Symbol
    Rnf103
  • Name
    ring finger protein 103
  • Synonyms
    kf-1, Zfp103
  • Feature Type
    protein coding gene
  • IDs
    MGI:109483
    NCBI Gene: 22644
Location & Maps
more
  • Sequence Map
    Chr6:71493894-71510881 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16988 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF103, ring finger protein 103
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNF103, ring finger protein 103
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HKF-1, KF1, KF-1, ZFP103, ZFP-103
  • Links
    NCBI Gene ID: 7844
    neXtProt AC: NX_O00237

  • Chr Location
    2p11.2; chr2:86603393-86623877 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4146
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RNF103
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Rnf103
  • Incidental Mutations
Mice homozygous for a knock-out allele display significantly increased anxiety-like behavior under stressful conditions as well as increased prepulse inhibition and a reduced startle amplitude with no detectable changes in exploratory locomotion or behavioral despair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023991 VEGA Gene Model | MGI Sequence Detail 16988 C57BL/6J ±  kb
transcript OTTMUST00000058650 VEGA | MGI Sequence Detail 3264 Not Applicable  
polypeptide OTTMUSP00000028453 VEGA | MGI Sequence Detail 683 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    229 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-39482, MGI:2141657, MGI:2141666
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:38480 Yasojima K, et al., Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Biochem Biophys Res Commun. 1997 Feb 13;231(2):481-7
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory