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Rnf103
Gene Detail
 Symbol
Name
ID
Rnf103
ring finger protein 103
MGI:109483
Synonyms kf-1, Zfp103
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:71493894-71525020 bp, + strand
From VEGA annotation of GRCm38

  31127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rnf103

Human
homologs
Human Homolog RNF103, ring finger protein 103
NCBI Gene ID 7844
neXtProt AC  NX_O00237
Human Synonyms  HKF-1, KF1, KF-1, ZFP103, ZFP-103
Human Chr (Location)  2p11.2; chr2:86603393-86623877 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display significantly increased anxiety-like behavior under stressful conditions as well as increased prepulse inhibition and a reduced startle amplitude with no detectable changes in exploratory locomotion or behavioral despair.
 
Interactions
Rnf103 interacts with 394 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ER-associated ubiquitin-dependent protein catabolic process, protein ubiquitination
Component endoplasmic reticulum, integral component of membrane, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (48)    Images (7)
Theiler Stages: 1, 2, 17, 21, 23, 28
Assay TypeResults
RNA in situ 56
RT-PCR 2
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023991 (Evidence)
Ensembl Gene ModelENSMUSG00000052656 (Evidence)
Entrez Gene22644 (Evidence)
UniGene422969
DFCITC1578700
DoTSDT.110497007, DT.489348, DT.94190117
EC6.3.2.-
Consensus CDS ProjectCCDS39508.1
International Mouse Knockout Project StatusRnf103
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023991 VEGA Gene Model | MGI Sequence Detail 31127 C57BL/6J ±  kb
transcript OTTMUST00000058650 VEGA | MGI Sequence Detail 3264 Not Applicable 
polypeptide OTTMUSP00000028453 VEGA | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000014065 E3 ubiquitin-protein ligase RNF103
References (Earliest) J:38480 Yasojima K, et al., Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Biochem Biophys Res Commun. 1997 Feb 13;231(2):481-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGD-MRK-39482, MGI:2141657, MGI:2141666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory