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Commd1 Gene Detail
Summary
  • Symbol
    Commd1
  • Name
    COMM domain containing 1
  • Synonyms
    Murr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109474
    NCBI Gene: 17846
  • Gene Overview
    MyGene.info: COMMD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:22896136-22982382 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86247 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.22 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    COMMD1, copper metabolism domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COMMD1, copper metabolism domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2orf5, MURR1
  • Links
    NCBI Gene ID: 150684
    neXtProt AC: NX_Q8N668
    UniProt: Q8N668

  • Chr Location
    2p15; chr2:61888723-62136070 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17604
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: COMMD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are embryonic lethal with growth retardation, failure to turn, increased apoptosis in brain mesenchyme and defects in extraembryonic tissue development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005270 VEGA Gene Model | MGI Sequence Detail 86247 C57BL/6J ±  kb
    transcript OTTMUST00000011742 VEGA | MGI Sequence Detail 1459 Not Applicable  
    polypeptide OTTMUSP00000005438 VEGA | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      275 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 15
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38519, MGI:2144104
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260042 Fedoseienko A, et al., COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Circ Res. 2018 Mar 15;None(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory