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Commd1
Gene Detail
Symbol

Name
ID
Commd1
COMM domain containing 1
MGI:109474
Synonyms
Murr1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:22896136-22982382 bp, - strand
From VEGA annotation of GRCm38

  86247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Commd1

Human
homologs
Human Homolog COMMD1, copper metabolism (Murr1) domain containing 1
NCBI Gene ID 150684
neXtProt AC  NX_Q8N668
Human Synonyms  C2orf5, MURR1
Human Chr (Location)  2p15; chr2:61888835-62136070 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele are embryonic lethal with growth retardation, failure to turn, increased apoptosis in brain mesenchyme and defects in extraembryonic tissue development.
 
Interactions
Commd1 interacts with 361 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular copper ion homeostasis, copper ion homeostasis, ...
Component cell, Cul2-RING ubiquitin ligase complex, ...
Function copper ion binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Western blot 6
RT-PCR 6
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005270 (Evidence)
Ensembl Gene ModelENSMUSG00000051355 (Evidence)
Entrez Gene17846 (Evidence)
DFCITC1576849, TC1764854, TC1592757
DoTSDT.55193082, DT.110501799, DT.495711, DT.110501720, DT.101404410, DT.101358006, DT.87033184
Consensus CDS ProjectCCDS24472.1
International Mouse Knockout Project StatusCommd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005270 VEGA Gene Model | MGI Sequence Detail 86247 C57BL/6J ±  kb
transcript OTTMUST00000011742 VEGA | MGI Sequence Detail 1459 Not Applicable 
polypeptide OTTMUSP00000005438 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(6) UniProt(11)
Polymorphisms
SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017920 COMM domain
InterPro IPR009886 HCaRG
Protein Ontology PR:000005729 COMM domain-containing protein 1
References
(Earliest) J:37668 Nabetani A, et al., Mouse U2af1-rs1 is a neomorphic imprinted gene. Mol Cell Biol. 1997 Feb;17(2):789-98
(Latest) J:182331 Vonk WI, et al., Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation. PLoS One. 2011;6(12):e29183
All references(37)
Other
accession IDs
MGD-MRK-38519, MGI:2144104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory