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Commd1 Gene Detail
Summary
  • Symbol
    Commd1
  • Name
    COMM domain containing 1
  • Synonyms
    Murr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109474
    NCBI Gene: 17846
  • Gene Overview
    MyGene.info: COMMD1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:22899728-22983108 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 14.22 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109474
protein coding gene Chr11:22896136-22983108 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018081
protein coding gene Chr11:20604839-20693475 (-)
A/J MGP_AJ_G0018054
protein coding gene Chr11:19820575-19907482 (-)
AKR/J MGP_AKRJ_G0018018
protein coding gene Chr11:20527028-20618246 (-)
BALB/cJ MGP_BALBcJ_G0018022
protein coding gene Chr11:19956469-20042866 (-)
C3H/HeJ MGP_C3HHeJ_G0017836
protein coding gene Chr11:20406960-20496194 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018474
protein coding gene Chr11:21459610-21551931 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016132
protein coding gene Chr11:18718241-18807342 (-)
CAST/EiJ MGP_CASTEiJ_G0017397
protein coding gene Chr11:20460011-20548193 (-)
CBA/J MGP_CBAJ_G0017810
protein coding gene Chr11:22411141-22505025 (-)
DBA/2J MGP_DBA2J_G0017920
protein coding gene Chr11:19751447-19837870 (-)
FVB/NJ MGP_FVBNJ_G0017912
protein coding gene Chr11:19524763-19613942 (-)
LP/J MGP_LPJ_G0017991
protein coding gene Chr11:20718730-20810614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017938
protein coding gene Chr11:22888370-22980363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018515
protein coding gene Chr11:20639421-20729177 (-)
PWK/PhJ MGP_PWKPhJ_G0017178
protein coding gene Chr11:19788864-19871877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016975
protein coding gene Chr11:20373731-20469126 (-)
WSB/EiJ MGP_WSBEiJ_G0017451
protein coding gene Chr11:20264427-20353120 (-)



Homology
more
  • Human Ortholog
    COMMD1, copper metabolism domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COMMD1, copper metabolism domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2orf5, MURR1
  • Links
    NCBI Gene ID: 150684
    neXtProt AC: NX_Q8N668
    UniProt: Q8N668

  • Chr Location
    2p15; chr2:61888723-62136070 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17604
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: COMMD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are embryonic lethal with growth retardation, failure to turn, increased apoptosis in brain mesenchyme and defects in extraembryonic tissue development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17846 NCBI Gene Model | MGI Sequence Detail 83381 C57BL/6J ±  kb
    transcript NM_001361661 RefSeq | MGI Sequence Detail 828 C57BL/6  
    polypeptide Q8K4M5 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38519, MGI:2144104
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260042 Fedoseienko A, et al., COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Circ Res. 2018 Mar 15;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory