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Commd1
Gene Detail
Symbol

Name
ID
Commd1
COMM domain containing 1
MGI:109474
Synonyms
Murr1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:22896136-22982382 bp, - strand
From VEGA annotation of GRCm38

  86247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COMMD1
Gene Tree: Commd1

Human
homologs
COMMD1, copper metabolism (Murr1) domain containing 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 150684
neXtProt AC: NX_Q8N668

Human Synonyms: C2orf5, MURR1

Human Chr (Location): 2p15; chr2:61888728-62136070 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele are embryonic lethal with growth retardation, failure to turn, increased apoptosis in brain mesenchyme and defects in extraembryonic tissue development.
 
Interactions
Commd1 interacts with 360 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular copper ion homeostasis, copper ion homeostasis, ...
Component cell, Cul2-RING ubiquitin ligase complex, ...
Function copper ion binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Western blot 6
RT-PCR 6
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase commd1    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005270 (Evidence)
Ensembl Gene Model ENSMUSG00000051355 (Evidence)
Entrez Gene 17846 (Evidence)
DFCI TC1576849, TC1592757, TC1764854
DoTS DT.495711, DT.101358006, DT.110501799, DT.110501720, DT.101404410, DT.87033184, DT.55193082
Consensus CDS Project CCDS24472.1
International Mouse Phenotyping Consortium Status Commd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005270 VEGA Gene Model | MGI Sequence Detail 86247 C57BL/6J ±  kb
transcript OTTMUST00000011742 VEGA | MGI Sequence Detail 1459 Not Applicable 
polypeptide OTTMUSP00000005438 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017920 COMM domain
InterPro IPR009886 HCaRG
Protein Ontology PR:000005729 COMM domain-containing protein 1
References
(Earliest) J:37668 Nabetani A, et al., Mouse U2af1-rs1 is a neomorphic imprinted gene. Mol Cell Biol. 1997 Feb;17(2):789-98
(Latest) J:218475 Bartuzi P, et al., A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta. 2014 Nov;1842(11):2257-65
All references(37)
Other
accession IDs
MGD-MRK-38519, MGI:2144104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory