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Ctcf
Gene Detail
Symbol

Name
ID
Ctcf
CCCTC-binding factor
MGI:109447
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:105636568-105682922 bp, + strand
From VEGA annotation of GRCm38

  46355 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ctcf

Human
homologs
Human Homolog CTCF, CCCTC-binding factor (zinc finger protein)
NCBI Gene ID 10664
neXtProt AC  NX_P49711
Human Synonyms  MRD21
Human Chr (Location)  16q21-q22.3; chr16:67562407-67639185 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTCF
Mutations,
alleles, and
phenotypes
All mutations/alleles(154) : Gene trapped(148) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior at implantation. Mice homozygous for a conditional allele activated in T cells exhibit a defect in the transition from immature single positive T cells to double positive T cells.
 
Interactions
Ctcf interacts with 302 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process chromatin modification, chromosome segregation, ...
Component chromosome, chromosome, centromeric region, ...
Function chromatin binding, chromatin insulator sequence binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (256)    Tissues (206)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
RT-PCR 100
cDNA source data(164)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(167) cDNA(165) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017298 (Evidence)
Ensembl Gene ModelENSMUSG00000005698 (Evidence)
Entrez Gene13018 (Evidence)
UniGene269474
DFCITC1574628
DoTSDT.534349, DT.101328902, DT.101137414
NIA Mouse Gene IndexU009750
Consensus CDS ProjectCCDS22606.1
International Mouse Knockout Project StatusCtcf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017298 VEGA Gene Model | MGI Sequence Detail 46355 C57BL/6J ±  kb
transcript OTTMUST00000041960 VEGA | MGI Sequence Detail 3782 Not Applicable 
polypeptide OTTMUSP00000018870 VEGA | MGI Sequence Detail 736 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(13) UniProt(9)
Polymorphisms
SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000005997 transcriptional repressor CTCF
References
(Earliest) J:33964 Filippova GN, et al., An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol. 1996 Jun;16(6):2802-13
(Latest) J:212499 Kim LK, et al., Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell. 2014 Apr 10;54(1):56-66
All references(93)
Other
accession IDs
MGD-MRK-38492, MGI:2142760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory