Ctcf
Gene Detail

Symbol Name ID

Ctcf CCCTC-binding factor MGI:109447

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:105636568-105682922 bp, + strand From VEGA annotation of GRCm38   46355 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctcf

Human homologs

Human Homolog		CTCF, CCCTC-binding factor (zinc finger protein)
NCBI Gene ID		10664
neXtProt AC		NX_P49711
Human Chr (Location)		16q21-q22.3; chr16:67596310-67673088 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(153) : Targeted(5) Gene trapped(148)
 

Mice homozygous for a null allele die prior to E9.5. Mice homozygous for a conditional allele activated in T cells exhibit a defect in the transition from immature single positive T cells to double positive T cells.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	chromatin modification, chromosome segregation, ...
Component	chromosome, chromosome, centromeric region, ...
Function	chromatin insulator sequence binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (263)    Tissues (205)    Images (14)
Theiler Stages: 2, 3, 4, 5, 17, 18, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	156
RT-PCR	107

cDNA source data(161)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(164) cDNA(162) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017298 (Evidence)
Ensembl Gene Model	ENSMUSG00000005698 (Evidence)
Entrez Gene	13018 (Evidence)
UniGene	269474
DFCI	TC1574628
DoTS	DT.101137414, DT.101328902, DT.534349
NIA Mouse Gene Index	U009750
Consensus CDS Project	CCDS22606.1
International Mouse Knockout Project Status	Ctcf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017298	VEGA Gene Model | MGI Sequence Detail	46355	C57BL/6J
transcript	OTTMUST00000041960	VEGA | MGI Sequence Detail	3782	Not Applicable
polypeptide	OTTMUSP00000018870	VEGA | MGI Sequence Detail	736	Not Applicable

All sequences(46) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000005997	transcriptional repressor CTCF

References

(Earliest) J:33964 Filippova GN, et al., An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol. 1996 Jun;16(6):2802-13
(Latest) J:195711 Shi F, et al., The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid. PLoS One. 2013;8(1):e53919
All references(84)

Other accession IDs

MGD-MRK-38492, MGI:2142760