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Ctcf Gene Detail
Summary
  • Symbol
    Ctcf
  • Name
    CCCTC-binding factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109447
    NCBI Gene: 13018
Location & Maps
more
  • Sequence Map
    Chr8:105636568-105682922 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46355 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CTCF, CCCTC-binding factor (zinc finger protein)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CTCF, CCCTC-binding factor (zinc finger protein)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MRD21
  • Links
    NCBI Gene ID: 10664
    neXtProt AC: NX_P49711

  • Chr Location
    16q21-q22.3; chr16:67562407-67639185 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4786
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CTCF
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CTCF associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 21; MRD21   OMIM: 615502
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior at implantation. Mice homozygous for a conditional allele activated in T cells exhibit a defect in the transition from immature single positive T cells to double positive T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017298 VEGA Gene Model | MGI Sequence Detail 46355 C57BL/6J ±  kb
transcript OTTMUST00000041960 VEGA | MGI Sequence Detail 3782 Not Applicable  
polypeptide OTTMUSP00000018870 VEGA | MGI Sequence Detail 736 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005997 transcriptional repressor CTCF
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 167
    cDNA 165
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38492, MGI:2142760
References
more
  • Summaries
    All 89
    Developmental Gene Expression 10
    Gene Ontology 16
    Phenotypes 21
  • Earliest
    J:33964 Filippova GN, et al., An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol. 1996 Jun;16(6):2802-13
  • Latest
    J:224312 Qiu Z, et al., Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol. 2015 Jan;35(1):224-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory