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Doc2a Gene Detail
Summary
  • Symbol
    Doc2a
  • Name
    double C2, alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:109446
    NCBI Gene: 13446
  • Gene Overview
    MyGene.info: DOC2A
Location & Maps
more
  • Sequence Map
    Chr7:126847416-126852705 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5290 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DOC2A, double C2 domain alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DOC2A, double C2 domain alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Doc2
  • Links
    NCBI Gene ID: 8448
    neXtProt AC: NX_Q14183

  • Chr Location
    16p11.2; chr16:30005514-30023280 (-)  GRCh38.p2

Human Diseases
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  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Genomic Mutations
    3 involving Doc2a
  • Incidental Mutations
Homozygous inactivation of this locus affects excitatory synaptic transmission, LTP, and learning/memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023358 VEGA Gene Model | MGI Sequence Detail 5290 C57BL/6J ±  kb
transcript OTTMUST00000056651 VEGA | MGI Sequence Detail 2538 Not Applicable  
polypeptide OTTMUSP00000027249 VEGA | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000006614 double C2-like domain-containing protein alpha
  • InterPro Domains
    IPR000008 C2 domain
    IPR030535 Double C2-like domain-containing protein alpha
    IPR014638 Double C2 protein, alpha/beta/gamma
    IPR001565 Synaptotagmin
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-38491
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Diseases 6
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:38862 Naito A, et al., Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain. Brain Res Mol Brain Res. 1997 Mar;44(2):198-204
  • Latest
    J:232211 de Jong AP, et al., Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5095-100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory