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Doc2a
Gene Detail
Symbol

Name
ID
Doc2a
double C2, alpha
MGI:109446
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.25 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:126847416-126852705 bp, + strand
From VEGA annotation of GRCm38

  5290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: double C2 protein, alpha/beta/gamma types
Gene Tree: Doc2a

Human
homologs
Human Homolog DOC2A, double C2-like domains, alpha
NCBI Gene ID 8448
neXtProt AC  NX_Q14183
Human Synonyms  Doc2
Human Chr (Location)  16p11.2; chr16:30005514-30021291 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Doc2a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus affects excitatory synaptic transmission, LTP, and learning/memory.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Doc2a interacts with 87 markers (Mir15a, Mir18, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process exocytosis, regulation of calcium ion-dependent exocytosis, ...
Component cell junction, cytoplasmic vesicle, ...
Function calcium-dependent phospholipid binding, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 2
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023358 (Evidence)
Ensembl Gene ModelENSMUSG00000052301 (Evidence)
Entrez Gene13446 (Evidence)
Consensus CDS ProjectCCDS21847.1
International Mouse Knockout Project StatusDoc2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023358 VEGA Gene Model | MGI Sequence Detail 5290 C57BL/6J ±  kb
transcript OTTMUST00000056651 VEGA | MGI Sequence Detail 2538 Not Applicable 
polypeptide OTTMUSP00000027249 VEGA | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(14) UniProt(14)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR014638 Double C2 protein, alpha/beta/gamma type
InterPro IPR001565 Synaptotagmin
Protein Ontology PR:000006614 double C2-like domain-containing protein alpha
References
(Earliest) J:38862 Naito A, et al., Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain. Brain Res Mol Brain Res. 1997 Mar;44(2):198-204
(Latest) J:202747 Pinheiro PS, et al., Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release. J Neurosci. 2013 Oct 16;33(42):16459-70
All references(33)
Other
accession IDs
MGD-MRK-38491

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory