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Gtpbp1 Gene Detail
Summary
  • Symbol
    Gtpbp1
  • Name
    GTP binding protein 1
  • Synonyms
    GP-1, GTPBP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109443
    NCBI Gene: 14904
  • Gene Overview
    MyGene.info: GTPBP1
Location & Maps
more
  • Sequence Map
    Chr15:79690896-79721479 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30584 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GTPBP1, GTP binding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GTPBP1, GTP binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP1, GP-1, HSPC018
  • Links
    NCBI Gene ID: 9567
    neXtProt AC: NX_O00178

  • Chr Location
    22q13.1; chr22:38704557-38738173 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3165
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GTPBP1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    23 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Gtpbp1
  • Incidental Mutations
Homozygous mice for a targeted null mutation were viable and fertile with no obvious morphological or behavioral defects. In addition, no defects in macrophage function were observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14904 NCBI Gene Model | MGI Sequence Detail 30584 C57BL/6J ±  kb
transcript NM_013818 RefSeq | MGI Sequence Detail 3444 C57BL/6  
polypeptide O08582 UniProt | EBI | MGI Sequence Detail 668 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008332 GTP-binding protein 1
  • PDB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR009000 Translation protein, beta-barrel domain
Molecular
Reagents
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  • All nucleic 113
    Genomic 1
    cDNA 112

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38488, MGI:2146115, MGI:2146176, MGI:2146305
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:38479 Senju S, et al., Identification of human and mouse GP-1, a putative member of a novel G-protein family. Biochem Biophys Res Commun. 1997 Feb 13;231(2):360-4
  • Latest
    J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory