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Gtpbp1 Gene Detail
Summary
  • Symbol
    Gtpbp1
  • Name
    GTP binding protein 1
  • Synonyms
    GP-1, GTPBP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109443
    NCBI Gene: 14904
  • Gene Overview
    MyGene.info: GTPBP1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79690896-79721479 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109443
protein coding gene Chr15:79690845-79721479 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022083
protein coding gene Chr15:79991537-80015732 (+)
A/J MGP_AJ_G0022044
protein coding gene Chr15:77221189-77245470 (+)
AKR/J MGP_AKRJ_G0022019
protein coding gene Chr15:79384777-79409077 (+)
BALB/cJ MGP_BALBcJ_G0022050
protein coding gene Chr15:77234980-77259315 (+)
C3H/HeJ MGP_C3HHeJ_G0021821
protein coding gene Chr15:79370851-79395233 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022493
protein coding gene Chr15:83132043-83163574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020023
protein coding gene Chr15:73696378-73720460 (+)
CAST/EiJ MGP_CASTEiJ_G0021342
protein coding gene Chr15:80080635-80106421 (+)
CBA/J MGP_CBAJ_G0021786
protein coding gene Chr15:85729413-85753794 (+)
DBA/2J MGP_DBA2J_G0021915
protein coding gene Chr15:76708095-76733206 (+)
FVB/NJ MGP_FVBNJ_G0021893
protein coding gene Chr15:75735438-75760736 (+)
LP/J MGP_LPJ_G0021983
protein coding gene Chr15:80178481-80204276 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021913
protein coding gene Chr15:90828199-90853580 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022507
protein coding gene Chr15:79403121-79427382 (+)
PWK/PhJ MGP_PWKPhJ_G0021084
protein coding gene Chr15:76718171-76744258 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020921
protein coding gene Chr15:79202233-79227616 (+)
WSB/EiJ MGP_WSBEiJ_G0021394
protein coding gene Chr15:79787947-79813289 (+)



Homology
more
  • Human Ortholog
    GTPBP1, GTP binding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GTPBP1, GTP binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP1, GP-1, HSPC018
  • Links
    NCBI Gene ID: 9567
    neXtProt AC: NX_O00178
    UniProt: O00178

  • Chr Location
    22q13.1; chr22:38704561-38738265 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3165
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GTPBP1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    23 phenotype references
Homozygous mice for a targeted null mutation were viable and fertile with no obvious morphological or behavioral defects. In addition, no defects in macrophage function were observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14904 NCBI Gene Model | MGI Sequence Detail 30584 C57BL/6J ±  kb
transcript NM_013818 RefSeq | MGI Sequence Detail 3444 C57BL/6  
polypeptide O08582 UniProt | EBI | MGI Sequence Detail 668 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008332 GTP-binding protein 1
  • PDB
  • InterPro Domains
    IPR039263 GTP-binding protein 1
    IPR035531 GTP binding protein 1-like, GTP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
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  • All nucleic 115
    Genomic 1
    cDNA 114

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38488, MGI:2146115, MGI:2146176, MGI:2146305
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory