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Icam5 Gene Detail
Summary
  • Symbol
    Icam5
  • Name
    intercellular adhesion molecule 5, telencephalin
  • Synonyms
    CD50, Icam3, Tlcn, TLN
  • Feature Type
    protein coding gene
  • IDs
    MGI:109430
    NCBI Gene: 15898
  • Gene Overview
    MyGene.info: ICAM5
Location & Maps
more
  • Sequence Map
    Chr9:21032038-21039036 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6999 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.70 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ICAM5, intercellular adhesion molecule 5
  • Vertebrate Orthologs
    14
  • Human Ortholog
    ICAM5, intercellular adhesion molecule 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TLCN, TLN
  • Links
    NCBI Gene ID: 7087
    neXtProt AC: NX_Q9UMF0

  • Chr Location
    19p13.2; chr19:10289435-10296778 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit enhanced long-term potentiation, sensorimotor gating, and reward-based learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15898 NCBI Gene Model | MGI Sequence Detail 6999 C57BL/6J ±  kb
transcript NM_008319 RefSeq | MGI Sequence Detail 2982 C57BL/6  
polypeptide Q60625 UniProt | EBI | MGI Sequence Detail 917 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 12
    Genomic 3
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-18600, MGD-MRK-38475, MGI:101792
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:38192 Yoshihara Y, et al., An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Neuron. 1994 Mar;12(3):541-53
  • Latest
    J:229641 Saito S, et al., RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Eur J Immunol. 2015 May;45(5):1512-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory