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Faf1 Gene Detail
Summary
  • Symbol
    Faf1
  • Name
    Fas-associated factor 1
  • Synonyms
    Dffrx, Fam
  • Feature Type
    protein coding gene
  • IDs
    MGI:109419
    NCBI Gene: 14084
  • Gene Overview
    MyGene.info: FAF1
Location & Maps
more
  • Sequence Map
    Chr4:109676588-109963960 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      287373 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 51.33 cM, cytoband C6
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FAF1, Fas associated factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAF1, Fas associated factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-03, hFAF1, HFAF1s, UBXD12, UBXN3A
  • Links
    NCBI Gene ID: 11124
    neXtProt AC: NX_Q9UNN5

  • Chr Location
    1p33; chr1:50441263-50960264 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5120
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FAF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    91
  • Chemically induced (other)
    2
  • Gene trapped
    85
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Faf1
  • Incidental Mutations
Homozygous fail to develop beyond 2-cell stage. Mice homozygous for a hypomorphic gene trap allele exhibit decreased susceptibility to dopaminergic neuron neurotoxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008482 VEGA Gene Model | MGI Sequence Detail 287373 C57BL/6J ±  kb
transcript OTTMUST00000019252 VEGA | MGI Sequence Detail 4468 Not Applicable  
polypeptide OTTMUSP00000008830 VEGA | MGI Sequence Detail 649 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    937 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 95
    Genomic 1
    cDNA 92
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38464, MGI:2140134
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:30163 Chu K, et al., A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11894-8
  • Latest
    J:215514 Saulnier A, et al., The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals. Cereb Cortex. 2013 Nov;23(11):2552-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory