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Reg3g
Gene Detail
 Symbol
Name
ID
Reg3g
regenerating islet-derived 3 gamma
MGI:109406
Synonyms RegIII (gamma)
Feature Type protein coding gene
Genetic Map
Chromosome 6
34.78 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:78466269-78468872 bp, - strand
From VEGA annotation of GRCm38

  2604 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

Gene Tree: Reg3g

Human
homologs
Human Homolog REG3G, regenerating islet-derived 3 gamma
NCBI Gene ID 130120
neXtProt AC  NX_Q6UW15
Human Synonyms  LPPM429, PAP1B, PAP-1B, PAPIB, PAP IB, REG III, REG-III, UNQ429
Human Chr (Location)  2p12; chr2:79025686-79028504 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele eshibit increased mucosal bacterial loads, T-helper 1 cells, and intestinal permeability.
 
Interactions
Reg3g interacts with 34 markers (Mir15a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process acute-phase response, defense response to Gram-positive bacterium, ...
Component cytoplasm, extracellular region
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (116)    Tissues (60)    Images (54)
Theiler Stages: 17, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 96
RT-PCR 8
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042157 (Evidence)
Ensembl Gene ModelENSMUSG00000030017 (Evidence)
Entrez Gene19695 (Evidence)
UniGene252385
DFCITC1580598, TC1609948
DoTSDT.101292839, DT.493849
NIA Mouse Gene IndexU027501
Consensus CDS ProjectCCDS20258.1
International Mouse Knockout Project StatusReg3g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042157 VEGA Gene Model | MGI Sequence Detail 2604 C57BL/6J ±  kb
transcript OTTMUST00000110621 VEGA | MGI Sequence Detail 771 Not Applicable 
polypeptide OTTMUSP00000061746 VEGA | MGI Sequence Detail 174 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000013872 regenerating islet-derived protein 3-gamma
References (Earliest) J:38547 Narushima Y, et al., Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997 Feb 7;185(2):159-68
(Latest) J:196462 Choi SM, et al., Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia. J Exp Med. 2013 Mar 11;210(3):551-61
All references(42)
Other
accession IDs
MGD-MRK-38451, MGI:2141414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory