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Reg3g
Gene Detail
Symbol

Name
ID
Reg3g
regenerating islet-derived 3 gamma
MGI:109406
Synonyms
RegIII (gamma)
Feature Type
protein coding gene
Genetic Map
Chromosome 6
34.78 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:78466269-78468872 bp, - strand
From VEGA annotation of GRCm38

  2604 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

HCOP human homology predictions: REG3G
Gene Tree: Reg3g

Human
homologs
REG3G, regenerating islet-derived 3 gamma
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 130120
neXtProt AC: NX_Q6UW15

Human Synonyms: LPPM429, PAP1B, PAP-1B, PAPIB, PAP IB, REG III, REG-III, UNQ429

Human Chr (Location): 2p12; chr2:79025686-79028504 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Genomic Mutations involving Reg3g (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele eshibit increased mucosal bacterial loads, T-helper 1 cells, and intestinal permeability.
 
Interactions
Reg3g interacts with 34 markers (Mir15a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process acute-phase response, defense response to Gram-positive bacterium, ...
Component cytoplasm, extracellular region
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (116)    Tissues (60)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 96
RT-PCR 8
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000042157 (Evidence)
Ensembl Gene Model ENSMUSG00000030017 (Evidence)
Entrez Gene 19695 (Evidence)
UniGene 252385
DFCI TC1609948, TC1580598
DoTS DT.101292839, DT.493849
NIA Mouse Gene Index U027501
Consensus CDS Project CCDS20258.1
International Mouse Phenotyping Consortium Status Reg3g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042157 VEGA Gene Model | MGI Sequence Detail 2604 C57BL/6J ±  kb
transcript OTTMUST00000110621 VEGA | MGI Sequence Detail 771 Not Applicable 
polypeptide OTTMUSP00000061746 VEGA | MGI Sequence Detail 174 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000013872 regenerating islet-derived protein 3-gamma
References
(Earliest) J:38547 Narushima Y, et al., Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997 Feb 7;185(2):159-68
(Latest) J:196462 Choi SM, et al., Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia. J Exp Med. 2013 Mar 11;210(3):551-61
All references(42)
Other
accession IDs
MGD-MRK-38451, MGI:2141414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory