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Reg3g Gene Detail
Summary
  • Symbol
    Reg3g
  • Name
    regenerating islet-derived 3 gamma
  • Synonyms
    RegIII (gamma)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109406
    NCBI Gene: 19695
  • Gene Overview
    MyGene.info: REG3G
Location & Maps
more
  • Sequence Map
    Chr6:78466269-78468872 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2604 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 34.78 cM, cytoband C
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    REG3G, regenerating family member 3 gamma
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REG3G, regenerating family member 3 gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LPPM429, PAP1B, PAP-1B, PAPIB, PAP IB, REG III, REG-III, UNQ429
  • Links
    NCBI Gene ID: 130120
    neXtProt AC: NX_Q6UW15

  • Chr Location
    2p12; chr2:79025686-79028504 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Reg3g
  • Incidental Mutations
Mice homozygous for a knock-out allele eshibit increased mucosal bacterial loads, T-helper 1 cells, and intestinal permeability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042157 VEGA Gene Model | MGI Sequence Detail 2604 C57BL/6J ±  kb
transcript OTTMUST00000110621 VEGA | MGI Sequence Detail 771 Not Applicable  
polypeptide OTTMUSP00000061746 VEGA | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 55
    Genomic 1
    cDNA 51
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38451, MGI:2141414
References
more
  • Summaries
    All 39
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:38547 Narushima Y, et al., Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997 Feb 7;185(2):159-68
  • Latest
    J:196462 Choi SM, et al., Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia. J Exp Med. 2013 Mar 11;210(3):551-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory