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Slc4a1
Gene Detail
Symbol

Name
ID
Slc4a1
solute carrier family 4 (anion exchanger), member 1
MGI:109393
STS
Synonyms
Ae1, band 3, CD233, Empb3, erythrocyte membrane protein band 3, l11Jus51
Feature Type
protein coding gene
Genetic Map
Chromosome 11
66.29 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:102348824-102366203 bp, - strand
From VEGA annotation of GRCm38

  17380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SLC4A1
Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a1

Human
homologs
SLC4A1, solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6521
neXtProt AC: NX_P02730

Human Synonyms: AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR

Human Chr (Location): 17q21.31; chr17:44248390-44268161 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human SLC4A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(1) Spontaneous(1) Targeted(8)
Genomic Mutations involving Slc4a1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null mutations exhibit retarded growth, severe spherocytosis, hemolytic anemia, lack of erythrocyte glycophorin A, mitotic defects, and high postnatal mortality.
 
Human Diseases Modeled in Mice Using Slc4a1 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Slc4a1 interacts with 177 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process anion transmembrane transport, anion transport, ...
Component basolateral plasma membrane, blood microparticle, ...
Function actin binding, anion:anion antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (57)    Tissues (12)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 51
RT-PCR 2
RNase protection 3
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc4a1 ; ZFIN slc4a1a, slc4a1b    NEW 
Molecular
reagents
All nucleic(146) Genomic(5) cDNA(134) Primer pair(4) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000002767 (Evidence)
Ensembl Gene Model ENSMUSG00000006574 (Evidence)
Entrez Gene 20533 (Evidence)
UniGene 7248
DFCI TC1748544, TC1573723
DoTS DT.101190353, DT.496052, DT.101406510, DT.101288034, DT.91300669, DT.99867086
NIA Mouse Gene Index U033475
Consensus CDS Project CCDS25496.1
International Mouse Phenotyping Consortium Status Slc4a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002767 VEGA Gene Model | MGI Sequence Detail 17380 C57BL/6J ±  kb
transcript OTTMUST00000005533 VEGA | MGI Sequence Detail 4545 Not Applicable 
polypeptide OTTMUSP00000002635 VEGA | MGI Sequence Detail 929 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(2) UniProt(11)
Polymorphisms
PCR(5) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018241 Anion exchange, conserved site
InterPro IPR001717 Anion exchange protein
InterPro IPR002977 Anion exchange protein 1
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
Protein Ontology PR:000002033 band 3 anion transport protein
References
(Earliest) J:35614 Kopito RR, et al., Primary structure and transmembrane orientation of the murine anion exchange protein. Nature. 1985 Jul 18-24;316(6025):234-8
(Latest) J:208725 Sui Z, et al., Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood. 2014 Jan 30;123(5):758-67
All references(103)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1167, MGD-MRK-38438, MGD-MRK-9369, MGI:2671335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory