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Noct Gene Detail
Summary
  • Symbol
    Noct
  • Name
    nocturnin
  • Synonyms
    Ccr4, Ccrn4l
  • Feature Type
    protein coding gene
  • IDs
    MGI:109382
    NCBI Gene: 12457
Location & Maps
more
  • Sequence Map
    Chr3:51224447-51251644 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27198 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NOCT, nocturnin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NOCT, nocturnin
    Orthology source: HomoloGene
  • Synonyms
    Ccr4c, CCR4L, CCRN4L, NOC
  • Links
    NCBI Gene ID: 25819
    neXtProt AC: NX_Q9UK39

  • Chr Location
    4q31.1; chr4:139015759-139045939 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7661
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: NOCT
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Gene trapped
    42
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Noct
  • Incidental Mutations
Mice homozygous for a null allele are resistant to diet-induced obesity and fatty liver development, show increased circulating glucose levels and increased insulin sensitivity on a standard diet and have impaired glucose tolerance on a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027519 VEGA Gene Model | MGI Sequence Detail 27198 C57BL/6J ±  kb
transcript OTTMUST00000068124 VEGA | MGI Sequence Detail 3059 Not Applicable  
polypeptide OTTMUSP00000034381 VEGA | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    261 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 23
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38427, MGI:2139914
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:38802 Puech A, et al., Characterization of two age-induced intracisternal A-particle-related transcripts in the mouse liver. Transcriptional read-through into an open reading frame with similarities to the yeast ccr4 transcription factor. J Biol Chem. 1997 Feb 28;272(9):5995-6003
  • Latest
    J:201137 Zhou K, et al., Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-E3829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory