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Il10rb
Gene Detail
Symbol

Name
ID
Il10rb
interleukin 10 receptor, beta
MGI:109380
Synonyms
6620401D04Rik, CRF2-4, Crfb4, D16H21S58, D21S58h, Il10r2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
52.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:91406164-91425834 bp, + strand
From VEGA annotation of GRCm38

  19671 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interleukin-10 receptor beta chain
Gene Tree: Il10rb

Human
homologs
Human Homolog IL10RB, interleukin 10 receptor, beta
NCBI Gene ID 3588
neXtProt AC  NX_Q08334
Human Synonyms  CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
Human Chr (Location)  21q22.11; chr21:33266360-33297234 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human IL10RB
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Il10rb (3)
Incidental mutations (data from Mutagenetix , APF )
 
Most mice homozygous for a knock-out allele develop moderate to severe colitis without small intestinal involvement and splenomegaly with a hyperproliferative splenic red pulp.
 
Interactions
Il10rb interacts with 290 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (200)    Tissues (155)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
Northern blot 40
RT-PCR 18
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(1) cDNA(54) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028329 (Evidence)
Ensembl Gene ModelENSMUSG00000022969 (Evidence)
Entrez Gene16155 (Evidence)
UniGene4154
DFCITC1577442, TC1621406
DoTSDT.101360065, DT.101735019, DT.533057, DT.94146367
NIA Mouse Gene IndexU017370, U237294
Consensus CDS ProjectCCDS37398.1
International Mouse Knockout Project StatusIl10rb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028329 VEGA Gene Model | MGI Sequence Detail 19671 C57BL/6J ±  kb
transcript OTTMUST00000070213 VEGA | MGI Sequence Detail 1850 Not Applicable 
polypeptide OTTMUSP00000035750 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
Protein Ontology PR:000008979 interleukin-10 receptor subunit beta
References
(Earliest) J:9328 Cheng SV, et al., Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6032-6
(Latest) J:195646 Mirpuri J, et al., Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. PLoS One. 2012;7(12):e51955
All references(52)
Other
accession IDs
MGD-MRK-38425, MGD-MRK-4247, MGD-MRK-5726, MGI:1918692, MGI:2146455, MGI:90448

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory