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Il10rb Gene Detail
Summary
  • Symbol
    Il10rb
  • Name
    interleukin 10 receptor, beta
  • Synonyms
    6620401D04Rik, CRF2-4, Crfb4, D16H21S58, D21S58h, Il10r2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109380
    NCBI Gene: 16155
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:91406164-91425834 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19671 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 52.87 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    IL10RB, interleukin 10 receptor subunit beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IL10RB, interleukin 10 receptor subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
  • Links
    NCBI Gene ID: 3588
    neXtProt AC: NX_Q08334
    UniProt: Q08334

  • Chr Location
    21q22.11; chr21:33266360-33297234 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL10RB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele develop moderate to severe colitis without small intestinal involvement and splenomegaly with a hyperproliferative splenic red pulp.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028329 VEGA Gene Model | MGI Sequence Detail 19671 C57BL/6J ±  kb
    transcript OTTMUST00000070213 VEGA | MGI Sequence Detail 1850 Not Applicable  
    polypeptide OTTMUSP00000035750 VEGA | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      76 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR015373 Interferon/interleukin receptor domain
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 1
      cDNA 54
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38425, MGD-MRK-4247, MGD-MRK-5726, MGI:1918692, MGI:2146455, MGI:90448
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:9328 Cheng SV, et al., Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6032-6
    • Latest
      J:253558 Redhu NS, et al., Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 Jul 5;6(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory