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Ell Gene Detail
Summary
  • Symbol
    Ell
  • Name
    elongation factor RNA polymerase II
  • Synonyms
    eleven-nineteen lysine-rich leukemia gene, Ell1, Men
  • Feature Type
    protein coding gene
  • IDs
    MGI:109377
    NCBI Gene: 13716
  • Gene Overview
    MyGene.info: ELL
Location & Maps
more
  • Sequence Map
    Chr8:70539457-70592858 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53402 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ELL, elongation factor for RNA polymerase II
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ELL, elongation factor for RNA polymerase II
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C19orf17, ELL1, MEN, PPP1R68
  • Links
    NCBI Gene ID: 8178
    neXtProt AC: NX_P55199

  • Chr Location
    19p13.11; chr19:18442663-18522129 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Targeted
    3
  • Genomic Mutations
    1 involving Ell
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele die prior to E6.5 but after implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061444 VEGA Gene Model | MGI Sequence Detail 53402 C57BL/6J ±  kb
transcript OTTMUST00000149925 VEGA | MGI Sequence Detail 3072 Not Applicable  
polypeptide OTTMUSP00000077747 VEGA | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    185 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    cDNA 77

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38422
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:38608 Thirman MJ, et al., Developmental analysis and subcellular localization of the murine homologue of ELL. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1408-13
  • Latest
    J:201955 Mourgues S, et al., ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17927-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory