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Ell Gene Detail
Summary
  • Symbol
    Ell
  • Name
    elongation factor RNA polymerase II
  • Synonyms
    eleven-nineteen lysine-rich leukemia gene, Ell1, Men
  • Feature Type
    protein coding gene
  • IDs
    MGI:109377
    NCBI Gene: 13716
  • Gene Overview
    MyGene.info: ELL
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70539675-70592858 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109377
protein coding gene Chr8:70539457-70592858 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033712
protein coding gene Chr8:70811636-70868440 (+)
A/J MGP_AJ_G0033695
protein coding gene Chr8:67938207-67992078 (+)
AKR/J MGP_AKRJ_G0033620
protein coding gene Chr8:69869059-69924692 (+)
BALB/cJ MGP_BALBcJ_G0033691
protein coding gene Chr8:68171750-68224867 (+)
C3H/HeJ MGP_C3HHeJ_G0033401
protein coding gene Chr8:70517568-70574758 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034208
protein coding gene Chr8:73490531-73549138 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031152
protein coding gene Chr8:62754803-62808745 (+)
CAST/EiJ MGP_CASTEiJ_G0032726
protein coding gene Chr8:69999930-70064643 (+)
CBA/J MGP_CBAJ_G0033379
protein coding gene Chr8:76127765-76184900 (+)
DBA/2J MGP_DBA2J_G0033533
protein coding gene Chr8:67654014-67707500 (+)
FVB/NJ MGP_FVBNJ_G0033474
protein coding gene Chr8:66773419-66833979 (+)
LP/J MGP_LPJ_G0033620
protein coding gene Chr8:70838769-70895305 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033517
protein coding gene Chr8:78794854-78852070 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034226
protein coding gene Chr8:70053903-70110764 (+)
PWK/PhJ MGP_PWKPhJ_G0032434
protein coding gene Chr8:66954239-67008381 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032270
protein coding gene Chr8:69027773-69077619 (+)
WSB/EiJ MGP_WSBEiJ_G0032841
protein coding gene Chr8:70416277-70471038 (+)



Homology
more
  • Human Ortholog
    ELL, elongation factor for RNA polymerase II
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ELL, elongation factor for RNA polymerase II
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C19orf17, ELL1, MEN, PPP1R68
  • Links
    NCBI Gene ID: 8178
    neXtProt AC: NX_P55199
    UniProt: P55199

  • Chr Location
    19p13.11; chr19:18442663-18522129 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prior to E6.5 but after implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13716 NCBI Gene Model | MGI Sequence Detail 53184 C57BL/6J ±  kb
transcript NM_007924 RefSeq | MGI Sequence Detail 3085 C57BL/6  
polypeptide O08856 UniProt | EBI | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38422
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:38608 Thirman MJ, et al., Developmental analysis and subcellular localization of the murine homologue of ELL. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1408-13
  • Latest
    J:238261 Ugale A, et al., Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation. Cell Rep. 2014 Nov 20;9(4):1246-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory