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Fut1
Gene Detail
Symbol

Name
ID
Fut1
fucosyltransferase 1
MGI:109375
Synonyms
H transferase
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:45617606-45621059 bp, + strand
From Ensembl annotation of GRCm38

  3454 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: FUT1
Gene Tree: Fut1

Human
homologs
FUT1, fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2523
neXtProt AC: NX_P19526

Human Synonyms: H, HH, HSC

Human Chr (Location): 19q13.3; chr19:48748011-48755390 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and healthy, lack alpha(1,2)fucose residues from the apical surface of pancreatic acinar glands and are deficient in epididymal cell surface alpha(1,2)fucosylated glycans but show normal male fertility.
 
Interactions
Fut1 interacts with 173 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process fucosylation, protein glycosylation
Function galactoside 2-alpha-L-fucosyltransferase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fut1    NEW 
Molecular
reagents
All nucleic(11) Genomic(4) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000008461 (Evidence)
Entrez Gene 14343 (Evidence)
DFCI TC1589554, TC1768520
DoTS DT.111016370, DT.91360740
NIA Mouse Gene Index U008082
EC 2.4.1.69
Consensus CDS Project CCDS21254.1
International Mouse Phenotyping Consortium Status Fut1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000008461 Ensembl Gene Model | MGI Sequence Detail 3454 C57BL/6J ±  kb
transcript ENSMUST00000008605 Ensembl | MGI Sequence Detail 2580 Not Applicable 
polypeptide ENSMUSP00000008605 Ensembl | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002516 Glycosyl transferase, family 11
Protein Ontology PR:000007702 galactoside 2-alpha-L-fucosyltransferase 1
References
(Earliest) J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
(Latest) J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80
All references(37)
Other
accession IDs
MGD-MRK-38420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory