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Fut1 Gene Detail
Summary
  • Symbol
    Fut1
  • Name
    fucosyltransferase 1
  • Synonyms
    H transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109375
    NCBI Gene: 14343
  • Gene Overview
    MyGene.info: FUT1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45617289-45621059 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.39 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109375
protein coding gene Chr7:45617266-45621059 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032233
protein coding gene Chr7:45917550-45920795 (+)
A/J MGP_AJ_G0032212
protein coding gene Chr7:45011752-45015208 (+)
AKR/J MGP_AKRJ_G0032148
protein coding gene Chr7:46260702-46264169 (+)
BALB/cJ MGP_BALBcJ_G0032224
protein coding gene Chr7:45005107-45008925 (+)
C3H/HeJ MGP_C3HHeJ_G0031939
protein coding gene Chr7:46751705-46754952 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032716
protein coding gene Chr7:48171780-48175247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029730
protein coding gene Chr7:47557236-47560611 (+)
CAST/EiJ MGP_CASTEiJ_G0031268
protein coding gene Chr7:38189805-38193011 (+)
CBA/J MGP_CBAJ_G0031904
protein coding gene Chr7:49771705-49778314 (+)
DBA/2J MGP_DBA2J_G0032062
protein coding gene Chr7:44689854-44693111 (+)
FVB/NJ MGP_FVBNJ_G0032013
protein coding gene Chr7:44462381-44465828 (+)
LP/J MGP_LPJ_G0032140
protein coding gene Chr7:46621819-46625074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032050
protein coding gene Chr7:48459868-48463300 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032732
protein coding gene Chr7:45470613-45473870 (+)
PWK/PhJ MGP_PWKPhJ_G0030990
protein coding gene Chr7:38057659-38060860 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030828
protein coding gene Chr7:33498628-33501912 (+)
WSB/EiJ MGP_WSBEiJ_G0031385
protein coding gene Chr7:45974851-45978243 (+)



Homology
more
  • Human Ortholog
    FUT1, fucosyltransferase 1 (H blood group)
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FUT1, fucosyltransferase 1 (H blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    H, HH, HSC
  • Links
    NCBI Gene ID: 2523
    neXtProt AC: NX_P19526
    UniProt: P19526

  • Chr Location
    19q13.33; chr19:48747826-48755390 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 120
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FUT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and healthy, lack alpha(1,2)fucose residues from the apical surface of pancreatic acinar glands and are deficient in epididymal cell surface alpha(1,2)fucosylated glycans but show normal male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008461 Ensembl Gene Model | MGI Sequence Detail 3771 C57BL/6J ±  kb
    transcript ENSMUST00000008605 Ensembl | MGI Sequence Detail 2580 Not Applicable  
    polypeptide ENSMUSP00000008605 Ensembl | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR002516 Glycosyl transferase, family 11
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 4
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38420
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
    • Latest
      J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory