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Fut2
Gene Detail
 Symbol
Name
ID
Fut2
fucosyltransferase 2
MGI:109374
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45648595-45666308 bp, - strand
From NCBI annotation of GRCm38

  17714 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 4 western clawed frog

Gene Tree: Fut2

Human
homologs
Human Homolog FUT2, fucosyltransferase 2 (secretor status included)
NCBI Gene ID 2524
neXtProt AC  NX_Q10981
Human Synonyms  B12QTL1, SE, Se2, SEC2, sej
Human Chr (Location)  19q13.3; chr19:48695971-48705934 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FUT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. Females are somewhate more susceptible to infections withCandida albicans.
 
Interactions
Fut2 interacts with 200 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process carbohydrate metabolic process, fucosylation, ...
Component extracellular vesicular exosome, Golgi apparatus, ...
Function fucosyltransferase activity, galactoside 2-alpha-L-fucosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000055978 (Evidence)
Entrez Gene14344 (Evidence)
DFCITC1584199, TC1697681, TC1743716
DoTSDT.101297805, DT.55250844, DT.99843832
NIA Mouse Gene IndexU155384
EC2.4.1.69
Consensus CDS ProjectCCDS21258.1
International Mouse Knockout Project StatusFut2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14344 NCBI Gene Model | MGI Sequence Detail 17714 C57BL/6J ±  kb
transcript NM_001271993 RefSeq | MGI Sequence Detail 3073 C57BL/6 
polypeptide Q9JL27 UniProt | EBI | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(198 from dbSNP Build 137)    SNPs within 2kb including multiple locations(206)
Protein-related
information
ResourceIDDescription
InterPro IPR002516 Glycosyl transferase, family 11
Protein Ontology PR:000007705 galactoside 2-alpha-L-fucosyltransferase 2
Graphical View of Protein Domain Structure
References (Earliest) J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
(Latest) J:202313 Kashyap PC, et al., Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17059-64
All references(42)
Other
accession IDs
MGD-MRK-38419

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory