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Fut2 Gene Detail
Summary
  • Symbol
    Fut2
  • Name
    fucosyltransferase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109374
    NCBI Gene: 14344
  • Gene Overview
    MyGene.info: FUT2
Location & Maps
more
  • Sequence Map
    Chr7:45648595-45666308 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17714 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.41 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FUT2, fucosyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FUT2, fucosyltransferase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B12QTL1, SE, Se2, SEC2, sej
  • Links
    NCBI Gene ID: 2524
    neXtProt AC: NX_Q10981

  • Chr Location
    19q13.3; chr19:48695971-48705934 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FUT2 associations

Human Disease Mouse Models
       Fucosyltransferase 2; FUT2   OMIM: 182100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for disruptions in this gene display an essentially normal phenotype. Females are somewhate more susceptible to infections withCandida albicans.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055978 Ensembl Gene Model | MGI Sequence Detail 17714 C57BL/6J ±  kb
transcript ENSMUST00000069800 Ensembl | MGI Sequence Detail 2865 Not Applicable  
polypeptide ENSMUSP00000063719 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    189 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007705 galactoside 2-alpha-L-fucosyltransferase 2
  • EC
  • InterPro Domains
    IPR002516 Glycosyl transferase, family 11
Molecular
Reagents
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  • All nucleic 7
    Genomic 1
    cDNA 5
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38419
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
  • Latest
    J:217494 Pickard JM, et al., Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature. 2014 Oct 30;514(7524):638-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory