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Fut2
Gene Detail
Symbol

Name
ID
Fut2
fucosyltransferase 2
MGI:109374
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45648595-45666308 bp, - strand
From Ensembl annotation of GRCm38

  17714 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 4 western clawed frog

HCOP human homology predictions: FUT2
Gene Tree: Fut2

Human
homologs
FUT2, fucosyltransferase 2 (secretor status included)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2524
neXtProt AC: NX_Q10981

Human Synonyms: B12QTL1, SE, Se2, SEC2, sej

Human Chr (Location): 19q13.3; chr19:48695971-48705934 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FUT2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. Females are somewhate more susceptible to infections withCandida albicans.
 
Interactions
Fut2 interacts with 199 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process carbohydrate metabolic process, fucosylation, ...
Component extracellular exosome, Golgi apparatus, ...
Function fucosyltransferase activity, galactoside 2-alpha-L-fucosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493351    NEW 
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000055978 (Evidence)
Entrez Gene 14344 (Evidence)
DFCI TC1697681, TC1584199, TC1743716
DoTS DT.99843832, DT.55250844, DT.101297805
NIA Mouse Gene Index U155384
EC 2.4.1.69
Consensus CDS Project CCDS21258.1
International Mouse Phenotyping Consortium Status Fut2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055978 Ensembl Gene Model | MGI Sequence Detail 17714 C57BL/6J ±  kb
transcript ENSMUST00000069800 Ensembl | MGI Sequence Detail 2865 Not Applicable 
polypeptide ENSMUSP00000063719 Ensembl | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(198 from dbSNP Build 137)    SNPs within 2kb including multiple locations(206)
Protein-related
information
ResourceIDDescription
InterPro IPR002516 Glycosyl transferase, family 11
Protein Ontology PR:000007705 galactoside 2-alpha-L-fucosyltransferase 2
References
(Earliest) J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
(Latest) J:217494 Pickard JM, et al., Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature. 2014 Oct 30;514(7524):638-41
All references(42)
Other
accession IDs
MGD-MRK-38419

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory