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Cbx5 Gene Detail
Summary
  • Symbol
    Cbx5
  • Name
    chromobox 5
  • Synonyms
    2610029O15Rik, heterochromatin protein 1 alpha, HP1, Hp1a, HP1a, Hp1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:109372
    NCBI Gene: 12419
  • Gene Overview
    MyGene.info: CBX5
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103191544-103239816 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109372
protein coding gene Chr15:103191544-103239904 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022434
protein coding gene Chr15:105436307-105491911 (-)
A/J MGP_AJ_G0022396
protein coding gene Chr15:101272629-101322404 (-)
AKR/J MGP_AKRJ_G0022371
protein coding gene Chr15:104344905-104394098 (-)
BALB/cJ MGP_BALBcJ_G0022400
protein coding gene Chr15:101319149-101368491 (-)
C3H/HeJ MGP_C3HHeJ_G0022167
protein coding gene Chr15:104432800-104488291 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022849
protein coding gene Chr15:109328742-109379505 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020372
protein coding gene Chr15:97039302-97085408 (-)
CAST/EiJ MGP_CASTEiJ_G0021693
protein coding gene Chr15:105305840-105360202 (-)
CBA/J MGP_CBAJ_G0022136
protein coding gene Chr15:113171386-113230382 (-)
DBA/2J MGP_DBA2J_G0022267
protein coding gene Chr15:100543270-100594824 (-)
FVB/NJ MGP_FVBNJ_G0022243
protein coding gene Chr15:99610072-99659157 (-)
LP/J MGP_LPJ_G0022336
protein coding gene Chr15:105577750-105639209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022265
protein coding gene Chr15:116683999-116732984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022861
protein coding gene Chr15:104388193-104438209 (-)
PWK/PhJ MGP_PWKPhJ_G0021433
protein coding gene Chr15:100726123-100776328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021265
protein coding gene Chr15:104222973-104274361 (-)
WSB/EiJ MGP_WSBEiJ_G0021743
protein coding gene Chr15:105005507-105056124 (-)



Homology
more
  • Human Ortholog
    CBX5, chromobox 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CBX5, chromobox 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL25, HP1, HP1A
  • Links
    NCBI Gene ID: 23468
    neXtProt AC: NX_P45973
    UniProt: P45973

  • Chr Location
    12q13.13; chr12:54230946-54280131 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation of this gene are viable and fertile and exhibit no apparent physical or behavioral abnormality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009575 Ensembl Gene Model | MGI Sequence Detail 48273 C57BL/6J ±  kb
    transcript ENSMUST00000108813 Ensembl | MGI Sequence Detail 3661 Not Applicable  
    polypeptide ENSMUSP00000104441 Ensembl | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 24
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-38417, MGI:1923790, MGI:2146269
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 14
      Gene Ontology 20
      Phenotypes 16
    • Earliest
      J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
    • Latest
      J:252201 Rapisarda V, et al., p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct;137(10):2157-2167

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory