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Cbx5 Gene Detail
Summary
  • Symbol
    Cbx5
  • Name
    chromobox 5
  • Synonyms
    2610029O15Rik, heterochromatin protein 1 alpha, HP1, Hp1a, HP1a, Hp1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:109372
    NCBI Gene: 12419
  • Gene Overview
    MyGene.info: CBX5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:103191544-103239816 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48273 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CBX5, chromobox 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CBX5, chromobox 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL25, HP1, HP1A
  • Links
    NCBI Gene ID: 23468
    neXtProt AC: NX_P45973
    UniProt: P45973

  • Chr Location
    12q13.13; chr12:54230946-54280131 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation of this gene are viable and fertile and exhibit no apparent physical or behavioral abnormality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030240 VEGA Gene Model | MGI Sequence Detail 48273 C57BL/6J ±  kb
    transcript OTTMUST00000074868 VEGA | MGI Sequence Detail 1146 Not Applicable  
    polypeptide OTTMUSP00000039140 VEGA | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      78 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 23
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-38417, MGI:1923790, MGI:2146269
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 14
      Gene Ontology 20
      Phenotypes 16
    • Earliest
      J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
    • Latest
      J:252201 Rapisarda V, et al., p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct;137(10):2157-2167

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory