About   Help   FAQ
Cbx5
Gene Detail
 Symbol
Name
ID
Cbx5
chromobox 5
MGI:109372
Synonyms 2610029O15Rik, heterochromatin protein 1 alpha, HP1, Hp1a, HP1a, Hp1alpha
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:103191544-103239816 bp, - strand
From VEGA annotation of GRCm38

  48273 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7257  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: heterochromatin protein 1 (HP1)
Gene Tree: Cbx5

Human
homologs
Human Homolog CBX5, chromobox homolog 5
NCBI Gene ID 23468
neXtProt AC  NX_P45973
Human Synonyms  HEL25, HP1, HP1A
Human Chr (Location)  12q13.13; chr12:54230946-54280131 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1052) : Gene trapped(1048) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a mutation of this gene are viable and fertile and exhibit no apparent physical or behavioral abnormality.
 
Interactions
Cbx5 interacts with 544 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process negative regulation of transcription, DNA-templated
Component chromocenter, chromosome, ...
Function chromatin binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (144)    Tissues (129)    Images (30)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 134
Western blot 7
RT-PCR 3
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000030240 (Evidence)
Ensembl Gene ModelENSMUSG00000009575 (Evidence)
Entrez Gene12419 (Evidence)
DFCITC1577812, TC1597202, TC1602728, TC1605404
DoTSDT.101142663, DT.101705948, DT.40157527, DT.493521, DT.97385880
NIA Mouse Gene IndexU036708, U073403
Consensus CDS ProjectCCDS37231.1
International Mouse Knockout Project StatusCbx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030240 VEGA Gene Model | MGI Sequence Detail 48273 C57BL/6J ±  kb
transcript OTTMUST00000074866 VEGA | MGI Sequence Detail 8803 Not Applicable 
polypeptide OTTMUSP00000039138 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(18) UniProt(2)
Polymorphisms SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR017984 Chromo domain subgroup
InterPro IPR008251 Chromo shadow domain
Protein Ontology PR:000005086 chromobox protein homolog 5
References (Earliest) J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
(Latest) J:201469 Sridharan R, et al., Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency. Nat Cell Biol. 2013 Jul;15(7):872-82
All references(80)
Other
accession IDs
MGD-MRK-38417, MGI:1923790, MGI:2146269

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory