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Cbx5 Gene Detail
Summary
  • Symbol
    Cbx5
  • Name
    chromobox 5
  • Synonyms
    2610029O15Rik, heterochromatin protein 1 alpha, HP1, Hp1a, HP1a, Hp1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:109372
    NCBI Gene: 12419
  • Gene Overview
    MyGene.info: CBX5
Location & Maps
more
  • Sequence Map
    Chr15:103191544-103239816 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48273 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CBX5, chromobox 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CBX5, chromobox 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL25, HP1, HP1A
  • Links
    NCBI Gene ID: 23468
    neXtProt AC: NX_P45973

  • Chr Location
    12q13.13; chr12:54230946-54280131 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation of this gene are viable and fertile and exhibit no apparent physical or behavioral abnormality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030240 VEGA Gene Model | MGI Sequence Detail 48273 C57BL/6J ±  kb
transcript OTTMUST00000074868 VEGA | MGI Sequence Detail 1146 Not Applicable  
polypeptide OTTMUSP00000039140 VEGA | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 23
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-38417, MGI:1923790, MGI:2146269
References
more
  • Summaries
    All 78
    Developmental Gene Expression 11
    Gene Ontology 18
    Phenotypes 16
  • Earliest
    J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
  • Latest
    J:201469 Sridharan R, et al., Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency. Nat Cell Biol. 2013 Jul;15(7):872-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory