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Hp1bp3 Gene Detail
Summary
  • Symbol
    Hp1bp3
  • Name
    heterochromatin protein 1, binding protein 3
  • Synonyms
    Hp1bp74, MGC:28927
  • Feature Type
    protein coding gene
  • IDs
    MGI:109369
    NCBI Gene: 15441
  • Gene Overview
    MyGene.info: HP1BP3
Location & Maps
more
  • Sequence Map
    Chr4:138216296-138244683 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28388 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.03 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HP1BP3, heterochromatin protein 1 binding protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HP1BP3, heterochromatin protein 1 binding protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HP1BP74, HP1-BP74
  • Links
    NCBI Gene ID: 50809
    neXtProt AC: NX_Q5SSJ5

  • Chr Location
    1p36.12; chr1:20742677-20787310 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    2
  • Gene trapped
    23
  • Targeted
    2
  • Genomic Mutations
    3 involving Hp1bp3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality and reduced body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009979 VEGA Gene Model | MGI Sequence Detail 28388 C57BL/6J ±  kb
transcript OTTMUST00000023193 VEGA | MGI Sequence Detail 5155 Not Applicable  
polypeptide OTTMUSP00000010588 VEGA | MGI Sequence Detail 554 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    275 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008726 heterochromatin protein 1-binding protein 3
  • InterPro Domains
    IPR033061 Heterochromatin protein 1-binding protein 3
    IPR005819 Histone H5
    IPR005818 Linker histone H1/H5, domain H15
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38414
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
  • Latest
    J:230411 Garfinkel BP, et al., Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway. Endocrinology. 2015 Dec;156(12):4558-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory