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Hp1bp3
Gene Detail
Symbol

Name
ID
Hp1bp3
heterochromatin protein 1, binding protein 3
MGI:109369
Synonyms
Hp1bp74, MGC:28927
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.03 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:138216296-138244683 bp, + strand
From VEGA annotation of GRCm38

  28388 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: HP1BP3
Gene Tree: Hp1bp3

Human
homologs
HP1BP3, heterochromatin protein 1, binding protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 50809
neXtProt AC: NX_Q5SSJ5

Human Synonyms: HP1BP74, HP1-BP74

Human Chr (Location): 1p36.12; chr1:20742677-20787310 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(23) Targeted(2)
Genomic Mutations involving Hp1bp3 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hp1bp3 interacts with 332 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to hypoxia, heterochromatin organization, ...
Component chromosome, nucleosome, ...
Function DNA binding, nucleosome binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hp1bp3    NEW 
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009979 (Evidence)
Ensembl Gene Model ENSMUSG00000028759 (Evidence)
Entrez Gene 15441 (Evidence)
DFCI TC1626781, TC1607546, TC1573547, TC1651470, TC1678855, TC1653587
NIA Mouse Gene Index U004994
Consensus CDS Project CCDS38927.1, CCDS51334.1
International Mouse Phenotyping Consortium Status Hp1bp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009979 VEGA Gene Model | MGI Sequence Detail 28388 C57BL/6J ±  kb
transcript OTTMUST00000023193 VEGA | MGI Sequence Detail 5155 Not Applicable 
polypeptide OTTMUSP00000010588 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(26) UniProt(9)
Polymorphisms
SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005818 Histone H1/H5
InterPro IPR005819 Histone H5
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008726 heterochromatin protein 1-binding protein 3
References
(Earliest) J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Other
accession IDs
MGD-MRK-38414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory