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Kcnk2
Gene Detail
 Symbol
Name
ID
Kcnk2
potassium channel, subfamily K, member 2
MGI:109366
Synonyms TREK-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
94.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:189207931-189343832 bp, - strand
From Ensembl annotation of GRCm38

  135902 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7794  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kcnk2

Human
homologs
Human Homolog KCNK2, potassium channel, subfamily K, member 2
NCBI Gene ID 3776
neXtProt AC  NX_O95069
Human Synonyms  hTREK-1c, hTREK-1e, K2p2.1, TPKC1, TREK, TREK1, TREK-1
Human Chr (Location)  1q41; chr1:215005542-215237093 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased sensitivity to pharmacologically induced seizures and ischemia.
 
Interactions
Kcnk2 interacts with 286 markers (Mir10a, Mir10b, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process G-protein coupled receptor signaling pathway, ion transport, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function outward rectifier potassium channel activity, potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (56)    Tissues (18)    Images (18)
Theiler Stages: 2, 3, 4, 23, 25, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 40
RT-PCR 13
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(12) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037624 (Evidence)
Entrez Gene16526 (Evidence)
NIA Mouse Gene IndexU022188
Consensus CDS ProjectCCDS48480.1, CCDS48481.1
International Mouse Knockout Project StatusKcnk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037624 Ensembl Gene Model | MGI Sequence Detail 135902 C57BL/6J ±  kb
transcript ENSMUST00000079451 Ensembl | MGI Sequence Detail 3405 Not Applicable 
polypeptide ENSMUSP00000078416 Ensembl | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(1132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR003976 Two pore domain potassium channel, TREK
Protein Ontology PR:000001914 potassium channel subfamily K member 2
References (Earliest) J:37545 Fink M, et al., Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 1996 Dec 16;15(24):6854-62
(Latest) J:203535 Berrier C, et al., The purified mechanosensitive channel TREK-1 is directly sensitive to membrane tension. J Biol Chem. 2013 Sep 20;288(38):27307-14
All references(56)
Other
accession IDs
MGD-MRK-38411, MGI:2138348

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory