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Kcnk2 Gene Detail
Summary
  • Symbol
    Kcnk2
  • Name
    potassium channel, subfamily K, member 2
  • Synonyms
    TREK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109366
    NCBI Gene: 16526
  • Gene Overview
    MyGene.info: KCNK2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:189207930-189402273 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 94.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109366
protein coding gene Chr1:189207930-189402704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016927
protein coding gene Chr1:196096634-196305350 (-)
A/J MGP_AJ_G0016906
protein coding gene Chr1:188087565-188288621 (-)
AKR/J MGP_AKRJ_G0016871
protein coding gene Chr1:193609673-193814897 (-)
BALB/cJ MGP_BALBcJ_G0016864
protein coding gene Chr1:188762511-188959723 (-)
C3H/HeJ MGP_C3HHeJ_G0016688
protein coding gene Chr1:194487092-194692685 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017327
protein coding gene Chr1:202380481-202584947 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015034
protein coding gene Chr1:179028043-179209354 (-)
CAST/EiJ MGP_CASTEiJ_G0016271
protein coding gene Chr1:194051976-194257457 (-)
CBA/J MGP_CBAJ_G0016662
protein coding gene Chr1:209902480-210140803 (-)
DBA/2J MGP_DBA2J_G0016768
protein coding gene Chr1:186829117-187021125 (-)
FVB/NJ MGP_FVBNJ_G0016764
protein coding gene Chr1:184929504-185124391 (-)
LP/J MGP_LPJ_G0016843
protein coding gene Chr1:197278498-197478755 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016796
protein coding gene Chr1:216637682-216851774 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017364
protein coding gene Chr1:193535037-193741219 (-)
PWK/PhJ MGP_PWKPhJ_G0016058
protein coding gene Chr1:186081016-186285461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015834
protein coding gene Chr1:192510280-192710068 (-)
WSB/EiJ MGP_WSBEiJ_G0016333
protein coding gene Chr1:193738147-193938871 (-)



Homology
more
  • Human Ortholog
    KCNK2, potassium two pore domain channel subfamily K member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNK2, potassium two pore domain channel subfamily K member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hTREK-1c, hTREK-1e, K2p2.1, TPKC1, TREK, TREK1, TREK-1
  • Links
    NCBI Gene ID: 3776
    neXtProt AC: NX_O95069
    UniProt: O95069

  • Chr Location
    1q41; chr1:215002920-215237093 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased sensitivity to pharmacologically induced seizures and ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037624 Ensembl Gene Model | MGI Sequence Detail 194344 C57BL/6J ±  kb
transcript ENSMUST00000193319 Ensembl | MGI Sequence Detail 1548 Not Applicable  
polypeptide ENSMUSP00000141891 Ensembl | MGI Sequence Detail 426 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 13
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38411, MGI:2138348
References
more
  • Summaries
    All 71
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:37545 Fink M, et al., Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 1996 Dec 16;15(24):6854-62
  • Latest
    J:251470 Schwingshackl A, et al., Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1030-L1046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory