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Kcnk2
Gene Detail
Symbol

Name
ID
Kcnk2
potassium channel, subfamily K, member 2
MGI:109366
Synonyms
TREK-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
94.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:189207930-189402273 bp, - strand
From VEGA annotation of GRCm38

  194344 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7794  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: KCNK2
Gene Tree: Kcnk2

Human
homologs
KCNK2, potassium channel, two pore domain subfamily K, member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3776
neXtProt AC: NX_O95069

Human Synonyms: hTREK-1c, hTREK-1e, K2p2.1, TPKC1, TREK, TREK1, TREK-1

Human Chr (Location): 1q41; chr1:215002639-215237093 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased sensitivity to pharmacologically induced seizures and ischemia.
 
Interactions
Kcnk2 interacts with 285 markers (Mir10a, Mir10b, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (56)    Tissues (19)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 40
RT-PCR 13
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnk2    NEW 
Molecular
reagents
All nucleic(15) cDNA(12) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051040 (Evidence)
Ensembl Gene Model ENSMUSG00000037624 (Evidence)
Entrez Gene 16526 (Evidence)
NIA Mouse Gene Index U022188
Consensus CDS Project CCDS48480.1, CCDS48481.1
International Mouse Phenotyping Consortium Status Kcnk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051040 VEGA Gene Model | MGI Sequence Detail 194344 C57BL/6J ±  kb
transcript OTTMUST00000129387 VEGA | MGI Sequence Detail 1548 Not Applicable 
polypeptide OTTMUSP00000069501 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(1406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR003976 Two pore domain potassium channel, TREK
Protein Ontology PR:000001914 potassium channel subfamily K member 2
References
(Earliest) J:37545 Fink M, et al., Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 1996 Dec 16;15(24):6854-62
(Latest) J:220586 Bando Y, et al., Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex. Cereb Cortex. 2014 Apr;24(4):1017-29
All references(58)
Other
accession IDs
MGD-MRK-38411, MGI:2138348

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory