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Napsa Gene Detail
Summary
  • Symbol
    Napsa
  • Name
    napsin A aspartic peptidase
  • Synonyms
    Kdap, NAP1, napsin, pronapsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109365
    NCBI Gene: 16541
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44221869-44236270 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    471 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109365
 protein coding gene Chr7:44221804-44236286 (+)
129S1/SvImJ ENSMUSG00200024644
 protein coding gene Chr7:31814412-31829057 (+)
A/J ENSMUSG00195046954
 protein coding gene Chr7:35842447-35856940 (+)
AKR/J ENSMUSG00220007468
 protein coding gene Chr7:30147337-30161993 (+)
BALB/cJ ENSMUSG00180035499
 protein coding gene Chr7:32717829-32732323 (+)
C3H/HeJ ENSMUSG00175034909
 protein coding gene Chr7:33250360-33264983 (+)
C57BL/6NJ ENSMUSG00215043361
 protein coding gene Chr7:32511555-32526049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029667
 protein coding gene Chr7:46514645-46528101 (+)
CAST/EiJ ENSTCUG00005045965
 protein coding gene Chr7:36227224-36241871 (+)
CBA/J ENSMUSG00210047098
 protein coding gene Chr7:33621752-33636376 (+)
DBA/2J ENSMUSG00185042660
 protein coding gene Chr7:37494366-37508679 (+)
FVB/NJ ENSMUSG00205035454
 protein coding gene Chr7:33166928-33181581 (+)
JF1/MsJ ENSUMUG00000014925
 protein coding gene Chr7:41981598-41995939 (+)
LP/J ENSMUSG00230050293
 protein coding gene Chr7:42917244-42931743 (+)
NOD/ShiLtJ ENSMUSG00190025297
 protein coding gene Chr7:33494712-33509357 (+)
NZO/HlLtJ ENSMUSG00225016120
 protein coding gene Chr7:41128037-41142528 (+)
PWK/PhJ ENSLUMG00010038008
 protein coding gene Chr7:32450602-32465070 (+)
SPRET/EiJ ENSMSPG00010039996
 protein coding gene Chr7:32231829-32246185 (+)
WSB/EiJ ENSIUOG00005024028
 protein coding gene Chr7:34039782-34054290 (+)



Homology
more
  • Human Ortholog
    NAPSA, napsin A aspartic peptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAPSA, napsin A aspartic peptidase
  • Synonyms
    KAP, Kdap, NAP1, NAPA, NR1H2-AS1, SNAPA
  • Links
    NCBI Gene ID: 9476
    UniProt: O96009

  • Chr Location
    19q13.33; chr19:50358472-50369302 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    103
  • cDNA Data
    11
  • Literature Summary
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16541 NCBI Gene Model | MGI Sequence Detail 14402 C57BL/6J ±  kb
transcript NM_008437 RefSeq | MGI Sequence Detail 1479 Not Specified  
polypeptide O09043 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 12
    Primer pair 2
    Other 2
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38410
References
more
  • Summaries
    All 47
    Developmental Gene Expression 15
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:38131 Mori K, et al., Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney. FEBS Lett. 1997 Jan 20;401(2-3):218-22
  • Latest
    J:213127 Jakus Z, et al., Lymphatic function is required prenatally for lung inflation at birth. J Exp Med. 2014 May 5;211(5):815-26
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory