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Napsa
Gene Detail
Symbol

Name
ID
Napsa
napsin A aspartic peptidase
MGI:109365
Synonyms
Kdap, NAP1, napsin, pronapsin
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:44572432-44586862 bp, + strand
From VEGA annotation of GRCm38

  14431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Pepsin
Gene Tree: Napsa

Human
homologs
Human Homolog NAPSA, napsin A aspartic peptidase
NCBI Gene ID 9476
neXtProt AC  NX_O96009
Human Synonyms  KAP, Kdap, NAP1, NAPA, SNAPA
Human Chr (Location)  19q13.33; chr19:50358477-50365674 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(13)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Napsa interacts with 10 markers (Mir18b, Mir296, Mir363, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (93)    Tissues (60)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 77
Western blot 11
RT-PCR 2
cDNA source data(255)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(258) cDNA(256) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021117 (Evidence)
Ensembl Gene ModelENSMUSG00000002204 (Evidence)
Entrez Gene16541 (Evidence)
UniGene383181
DFCITC1572330, TC1716220
DoTSDT.496128, DT.55127147
NIA Mouse Gene IndexU008045
EC3.4.23.-
Consensus CDS ProjectCCDS21212.1
International Mouse Knockout Project StatusNapsa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021117 VEGA Gene Model | MGI Sequence Detail 14431 C57BL/6J ±  kb
transcript OTTMUST00000049974 VEGA | MGI Sequence Detail 1508 Not Applicable 
polypeptide OTTMUSP00000023258 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
Protein Ontology PR:000010986 napsin-A
References
(Earliest) J:38131 Mori K, et al., Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney. FEBS Lett. 1997 Jan 20;401(2-3):218-22
(Latest) J:202949 Chang DR, et al., Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18042-51
All references(49)
Other
accession IDs
MGD-MRK-38410

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory