Napsa
Gene Detail

Symbol Name ID

Napsa napsin A aspartic peptidase MGI:109365

Synonyms

Kdap, NAP1, napsin, pronapsin

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:44572432-44586862 bp, + strand From VEGA annotation of GRCm38   14431 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Pepsin
Gene Tree: Napsa

Human homologs

Human Homolog		NAPSA, napsin A aspartic peptidase
NCBI Gene ID		9476
neXtProt AC		NX_O96009
Human Synonyms		KAP, Kdap, NAP1, NAPA, SNAPA
Human Chr (Location)		19q13.33; chr19:50861734-50868931 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Gene trapped(13)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	membrane protein proteolysis, proteolysis, ...
Component	alveolar lamellar body, extracellular region, ...
Function	aspartic-type endopeptidase activity, endopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (93)    Tissues (59)    Images (10)
Theiler Stages: 11, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	77
Western blot	11
RT-PCR	2

cDNA source data(253)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(256) cDNA(254) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021117 (Evidence)
Ensembl Gene Model	ENSMUSG00000002204 (Evidence)
Entrez Gene	16541 (Evidence)
UniGene	383181
DFCI	TC1572330, TC1716220
DoTS	DT.496128, DT.55127147
NIA Mouse Gene Index	U008045
EC	3.4.23.-
Consensus CDS Project	CCDS21212.1
International Mouse Knockout Project Status	Napsa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021117	VEGA Gene Model | MGI Sequence Detail	14431	C57BL/6J
transcript	OTTMUST00000049974	VEGA | MGI Sequence Detail	1508	Not Applicable
polypeptide	OTTMUSP00000023258	VEGA | MGI Sequence Detail	419	Not Applicable

All sequences(31) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(169 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR021109	Aspartic peptidase
InterPro	IPR001461	Peptidase A1
InterPro	IPR001969	Peptidase aspartic, active site
Protein Ontology	PR:000010986	napsin-A

References

(Earliest) J:38131 Mori K, et al., Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney. FEBS Lett. 1997 Jan 20;401(2-3):218-22
(Latest) J:190056 Xu Y, et al., Transcriptional programs controlling perinatal lung maturation. PLoS One. 2012;7(8):e37046
All references(47)

Other accession IDs

MGD-MRK-38410