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Krt36 Gene Detail
Summary
  • Symbol
    Krt36
  • Name
    keratin 36
  • Synonyms
    HRa-1, keratin 5, Krt1-22, Krt1-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109364
    NCBI Gene: 16673
  • Gene Overview
    MyGene.info: KRT36
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100102007-100105626 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.41 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109364
protein coding gene Chr11:100102007-100109487 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019140
protein coding gene Chr11:102849125-102852744 (-)
A/J MGP_AJ_G0019108
protein coding gene Chr11:98508288-98511907 (-)
AKR/J MGP_AKRJ_G0019077
protein coding gene Chr11:101552421-101556034 (-)
BALB/cJ MGP_BALBcJ_G0019082
protein coding gene Chr11:99024664-99028283 (-)
C3H/HeJ MGP_C3HHeJ_G0018891
protein coding gene Chr11:101748259-101751878 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019531
protein coding gene Chr11:106017971-106021590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017158
protein coding gene Chr11:95961446-95965069 (-)
CAST/EiJ MGP_CASTEiJ_G0018445
protein coding gene Chr11:102730143-102733765 (-)
CBA/J MGP_CBAJ_G0018860
protein coding gene Chr11:110452049-110455668 (-)
DBA/2J MGP_DBA2J_G0018973
protein coding gene Chr11:98082697-98086316 (-)
FVB/NJ MGP_FVBNJ_G0018962
protein coding gene Chr11:97583519-97587138 (-)
LP/J MGP_LPJ_G0019041
protein coding gene Chr11:103388244-103391863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018993
protein coding gene Chr11:110077196-110080815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019569
protein coding gene Chr11:101930420-101934039 (-)
PWK/PhJ MGP_PWKPhJ_G0018208
protein coding gene Chr11:99113607-99117224 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018000
protein coding gene Chr11:101629959-101633580 (-)
WSB/EiJ MGP_WSBEiJ_G0018494
protein coding gene Chr11:101897270-101900889 (-)



Homology
more
  • Human Ortholog
    KRT36, keratin 36
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KRT36, keratin 36
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HA6, hHa6, KRTHA6
  • Links
    NCBI Gene ID: 8689
    neXtProt AC: NX_O76013
    UniProt: O76013

  • Chr Location
    17q21.2; chr17:41486136-41489864 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hyperkeratosis affecting the scales of the tail skin and the filiform papillae of the tongue.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020916 Ensembl Gene Model | MGI Sequence Detail 3620 C57BL/6J ±  kb
    transcript ENSMUST00000107416 Ensembl | MGI Sequence Detail 1671 Not Applicable  
    polypeptide ENSMUSP00000103039 Ensembl | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38409
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:2252 Tobiasch E, et al., Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Differentiation. 1992 Aug;50(3):163-78
    • Latest
      J:242196 Xu M, et al., WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 07;8:15397

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory