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Krt86 Gene Detail
Summary
  • Symbol
    Krt86
  • Name
    keratin 86
  • Synonyms
    Khb4, Krt2-10, Krt2-11, MHb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109362
    NCBI Gene: 16679
  • Gene Overview
    MyGene.info: KRT86
Location & Maps
more
  • Sequence Map
    Chr15:101473478-101479983 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6506 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.90 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KRT86, keratin 86
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KRT86, keratin 86
    Orthology source: HomoloGene
  • Synonyms
    Hb1, HB6, K86, KRTHB1, KRTHB6, MNX
  • Links
    NCBI Gene ID: 3892
    neXtProt AC: NX_O43790

  • Chr Location
    12q13; chr12:52274631-52309163 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KRT86 associations

Human Disease Mouse Models
       Monilethrix; MNLIX   OMIM: 158000
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    4 involving Krt86
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16679 NCBI Gene Model | MGI Sequence Detail 6506 C57BL/6J ±  kb
transcript NM_010667 RefSeq | MGI Sequence Detail 1960 C57BL/6  
polypeptide P97861 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    40 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009502 keratin, type II cuticular Hb6
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 19
    Genomic 9
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38407, MGI:2145983
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 22
  • Earliest
    J:22955 Knapp B, et al., Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res. 1986 Jan 24;14(2):751-63
  • Latest
    J:198837 Cui CY, et al., Frizzled6 deficiency disrupts the differentiation process of nail development. J Invest Dermatol. 2013 Aug;133(8):1990-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory