About   Help   FAQ
Lmo4
Gene Detail
Symbol

Name
ID
Lmo4
LIM domain only 4
MGI:109360
Synonyms
A730077C12Rik, Crp3, Etohi4
Feature Type
protein coding gene
Genetic Map
Chromosome 3
68.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:144188530-144205220 bp, - strand
From VEGA annotation of GRCm38

  16691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LMO4
Gene Tree: Lmo4

Human
homologs
LMO4, LIM domain only 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8543
neXtProt AC: NX_P61968

Human Chr (Location): 1p22.3; chr1:87328468-87348923 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(9) Targeted(13)
 
Homozygous null mice die embryonically and exhibit a failure of neural tube closure and exencephaly, which is associated with abnormal patterns of cell proliferation and with high levels of apoptosis within the neuroepithelium.
 
Human Diseases Modeled in Mice Using Lmo4 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Lmo4 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (73 records)
Data Summary: Results (319)    Tissues (166)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 269
Northern blot 35
RT-PCR 12
cDNA source data(182)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LMO4 ; Xenbase lmo4.1, lmo4.2 ; ZFIN lmo4a, lmo4b    NEW 
Molecular
reagents
All nucleic(188) cDNA(184) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029080 (Evidence)
Ensembl Gene Model ENSMUSG00000028266 (Evidence)
Entrez Gene 16911 (Evidence)
UniGene 29187
DFCI TC1603547, TC1572885, TC1603467, TC1591815, TC1591251
DoTS DT.55257054, DT.535507, DT.101123245, DT.94223263, DT.94223254
NIA Mouse Gene Index U024721
PDB 1M3V, 1RUT, 2MBV, 2DFY
Consensus CDS Project CCDS51085.1
International Mouse Phenotyping Consortium Status Lmo4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029080 VEGA Gene Model | MGI Sequence Detail 16691 C57BL/6J ±  kb
transcript OTTMUST00000072133 VEGA | MGI Sequence Detail 1669 Not Applicable 
polypeptide OTTMUSP00000037059 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009864 LIM domain transcription factor LMO4
References
(Earliest) J:44447 Baumeister A, et al., Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997 Dec 1;139(5):1231-42
(Latest) J:221123 Qin Z, et al., Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31
All references(122)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-38405, MGI:1261430, MGI:2443844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory