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Lmo4
Gene Detail
 Symbol
Name
ID
Lmo4
LIM domain only 4
MGI:109360
Synonyms A730077C12Rik, Crp3, Etohi4
Feature Type protein coding gene
Genetic Map
Chromosome 3
68.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:144188530-144205220 bp, - strand
From VEGA annotation of GRCm38

  16691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lmo4

Human
homologs
Human Homolog LMO4, LIM domain only 4
NCBI Gene ID 8543
neXtProt AC  NX_P61968
Human Chr (Location)  1p22.3; chr1:87328468-87348923 (+)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Targeted(13) Gene trapped(9)
 
Homozygous null mice die embryonically and exhibit a failure of neural tube closure and exencephaly, which is associated with abnormal patterns of cell proliferation and with high levels of apoptosis within the neuroepithelium.
 
Human Diseases Modeled Using Mouse Lmo4 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process negative regulation of protein complex assembly, neural tube closure, ...
Component transcription factor complex
Function enhancer sequence-specific DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (269)    Tissues (135)    Images (44)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 227
Northern blot 24
RT-PCR 15
cDNA source data(182)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(186) cDNA(184) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029080 (Evidence)
Ensembl Gene ModelENSMUSG00000028266 (Evidence)
Entrez Gene16911 (Evidence)
UniGene29187
DFCITC1572885, TC1591251, TC1591815, TC1603467, TC1603547
DoTSDT.101123245, DT.535507, DT.55257054, DT.94223254, DT.94223263
NIA Mouse Gene IndexU024721
PDB1M3V, 1RUT, 2DFY
Consensus CDS ProjectCCDS51085.1
International Mouse Knockout Project StatusLmo4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029080 VEGA Gene Model | MGI Sequence Detail 16691 C57BL/6J ±  kb
transcript OTTMUST00000072133 VEGA | MGI Sequence Detail 1669 Not Applicable 
polypeptide OTTMUSP00000037059 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009864 LIM domain transcription factor LMO4
References (Earliest) J:44447 Baumeister A, et al., Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997 Dec 1;139(5):1231-42
(Latest) J:205589 Zaman T, et al., LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J Neurosci. 2014 Jan 1;34(1):140-8
All references(116)
Other
accession IDs
MGD-MRK-38405, MGI:1261430, MGI:2443844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory