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Lmo4 Gene Detail
Summary
  • Symbol
    Lmo4
  • Name
    LIM domain only 4
  • Synonyms
    A730077C12Rik, Crp3, Etohi4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109360
    NCBI Gene: 16911
  • Gene Overview
    MyGene.info: LMO4
Location & Maps
more
  • Sequence Map
    Chr3:144188530-144205220 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16691 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 68.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LMO4, LIM domain only 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LMO4, LIM domain only 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8543
    neXtProt AC: NX_P61968

  • Chr Location
    1p22.3; chr1:87328468-87348923 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4927
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LMO4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lmo4 mouse models

Human Disease Mouse Models
       Anencephaly   OMIM: 206500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 10 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    13
  • Genomic Mutations
    1 involving Lmo4
Homozygous null mice die embryonically and exhibit a failure of neural tube closure and exencephaly, which is associated with abnormal patterns of cell proliferation and with high levels of apoptosis within the neuroepithelium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029080 VEGA Gene Model | MGI Sequence Detail 16691 C57BL/6J ±  kb
transcript OTTMUST00000072137 VEGA | MGI Sequence Detail 1417 Not Applicable  
polypeptide OTTMUSP00000037063 VEGA | MGI Sequence Detail 165 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    72 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 188
    cDNA 184
    Primer pair 1
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38405, MGI:1261430, MGI:2443844
References
more
  • Summaries
    All 128
    Developmental Gene Expression 79
    Diseases 1
    Gene Ontology 13
    Phenotypes 34
  • Earliest
    J:44447 Baumeister A, et al., Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997 Dec 1;139(5):1231-42
  • Latest
    J:230652 Harb K, et al., Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory