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Nek2 Gene Detail
Summary
  • Symbol
    Nek2
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109359
    NCBI Gene: 18005
  • Gene Overview
    MyGene.info: NEK2
Location & Maps
more
  • Sequence Map
    Chr1:191821444-191833050 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11607 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    NEK2, NIMA related kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NEK2, NIMA related kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HsPK21, NEK2A, NLK1, PPP1R111, RP67
  • Links
    NCBI Gene ID: 4751
    neXtProt AC: NX_P51955

  • Chr Location
    1q32.3; chr1:211658256-211675630 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 74441
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NEK2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human NEK2 associations

Human Disease Mouse Models
       Retinitis Pigmentosa 67; RP67   OMIM: 615565
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027018 VEGA Gene Model | MGI Sequence Detail 11607 C57BL/6J ±  kb
transcript OTTMUST00000066791 VEGA | MGI Sequence Detail 3227 Not Applicable  
polypeptide OTTMUSP00000033520 VEGA | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011128 serine/threonine-protein kinase Nek2
  • EC
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 30
    cDNA 25
    Primer pair 5

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-38404, MGI:2138121, MGI:2138656
References
more
  • Summaries
    All 39
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 3
  • Earliest
    J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
  • Latest
    J:208452 Sasaki Y, et al., Molecular contribution to cleft palate production in cleft lip mice. Congenit Anom (Kyoto). 2014 May;54(2):94-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory