About   Help   FAQ
Nek2 Gene Detail
Summary
  • Symbol
    Nek2
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109359
    NCBI Gene: 18005
  • Gene Overview
    MyGene.info: NEK2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191821444-191833050 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 96.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109359
protein coding gene Chr1:191821281-191833050 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016948
protein coding gene Chr1:198899511-198911211 (+)
A/J MGP_AJ_G0016927
protein coding gene Chr1:190733487-190745139 (+)
AKR/J MGP_AKRJ_G0016892
protein coding gene Chr1:196406965-196418619 (+)
BALB/cJ MGP_BALBcJ_G0016885
protein coding gene Chr1:191412523-191424177 (+)
C3H/HeJ MGP_C3HHeJ_G0016709
protein coding gene Chr1:197246174-197257649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017348
protein coding gene Chr1:205242396-205254002 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015055
protein coding gene Chr1:181634086-181645868 (+)
CAST/EiJ MGP_CASTEiJ_G0016292
protein coding gene Chr1:196838549-196850210 (+)
CBA/J MGP_CBAJ_G0016683
protein coding gene Chr1:212841398-212855772 (+)
DBA/2J MGP_DBA2J_G0016789
protein coding gene Chr1:189455961-189468496 (+)
FVB/NJ MGP_FVBNJ_G0016785
protein coding gene Chr1:187580283-187593042 (+)
LP/J MGP_LPJ_G0016864
protein coding gene Chr1:200086204-200097683 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016817
protein coding gene Chr1:219498762-219511946 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017385
protein coding gene Chr1:196269073-196282678 (+)
PWK/PhJ MGP_PWKPhJ_G0016079
protein coding gene Chr1:188754323-188766117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015855
protein coding gene Chr1:195278670-195294354 (+)
WSB/EiJ MGP_WSBEiJ_G0016354
protein coding gene Chr1:196518975-196532861 (+)



Homology
more
  • Human Ortholog
    NEK2, NIMA related kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NEK2, NIMA related kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HsPK21, NEK2A, NLK1, PPP1R111, RP67
  • Links
    NCBI Gene ID: 4751
    neXtProt AC: NX_P51955
    UniProt: P51955

  • Chr Location
    1q32.3; chr1:211658256-211675630 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74441
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEK2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human NEK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026622 Ensembl Gene Model | MGI Sequence Detail 11607 C57BL/6J ±  kb
transcript ENSMUST00000027931 Ensembl | MGI Sequence Detail 3227 Not Applicable  
polypeptide ENSMUSP00000027931 Ensembl | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 26
    Primer pair 5

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38404, MGI:2138121, MGI:2138656
References
more
  • Summaries
    All 41
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
  • Latest
    J:208452 Sasaki Y, et al., Molecular contribution to cleft palate production in cleft lip mice. Congenit Anom (Kyoto). 2014 May;54(2):94-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory