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Nek2
Gene Detail
 Symbol
Name
ID
Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
MGI:109359
Feature Type protein coding gene
Genetic Map
Chromosome 1
96.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:191821444-191833050 bp, + strand
From VEGA annotation of GRCm38

  11607 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74441  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nek2

Human
homologs
Human Homolog NEK2, NIMA-related kinase 2
NCBI Gene ID 4751
neXtProt AC  NX_P51955
Human Synonyms  HsPK21, NEK2A, NLK1, PPP1R111, RP67
Human Chr (Location)  1q32.3; chr1:211658256-211675630 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NEK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nek2 interacts with 200 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process blastocyst development, cell cycle, ...
Component centrosome, chromosome, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (16)    Tissues (8)   
Theiler Stages: 1, 20, 23, 26, 27, 28
Assay TypeResults
Western blot 3
RT-PCR 13
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(25) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027018 (Evidence)
Ensembl Gene ModelENSMUSG00000026622 (Evidence)
Entrez Gene18005 (Evidence)
DFCITC1577192, TC1586787, TC1596575
NIA Mouse Gene IndexU001295
EC2.7.11.1
Consensus CDS ProjectCCDS15623.1
International Mouse Knockout Project StatusNek2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027018 VEGA Gene Model | MGI Sequence Detail 11607 C57BL/6J ±  kb
transcript OTTMUST00000066791 VEGA | MGI Sequence Detail 3227 Not Applicable 
polypeptide OTTMUSP00000033520 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011128 serine/threonine-protein kinase Nek2
References (Earliest) J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
(Latest) J:199098 Shimizu K, et al., Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. FEBS Lett. 2013 Jul 11;587(14):2219-25
All references(38)
Other
accession IDs
MGD-MRK-38404, MGI:2138121, MGI:2138656

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory