Nek2 MGI Mouse Gene Detail - MGI:109359 - NIMA (never in mitosis gene a)-related expressed kinase 2

Symbol

Nek2
Name

NIMA (never in mitosis gene a)-related expressed kinase 2

Feature Type

protein coding gene
IDs

MGI:109359
NCBI Gene: 18005
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:191553556-191565162 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 96.94 cM
Mapping Data

2 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109359	protein coding gene	Chr1:191552487-191565162 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016948	protein coding gene	Chr1:198899511-198911211 (+)
A/J	MGP_AJ_G0016927	protein coding gene	Chr1:190733487-190745139 (+)
AKR/J	MGP_AKRJ_G0016892	protein coding gene	Chr1:196406965-196418619 (+)
BALB/cJ	MGP_BALBcJ_G0016885	protein coding gene	Chr1:191412523-191424177 (+)
C3H/HeJ	MGP_C3HHeJ_G0016709	protein coding gene	Chr1:197246174-197257649 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017348	protein coding gene	Chr1:205242396-205254002 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015055	protein coding gene	Chr1:181634086-181645868 (+)
CAST/EiJ	MGP_CASTEiJ_G0016292	protein coding gene	Chr1:196838549-196850210 (+)
CBA/J	MGP_CBAJ_G0016683	protein coding gene	Chr1:212841398-212855772 (+)
DBA/2J	MGP_DBA2J_G0016789	protein coding gene	Chr1:189455961-189468496 (+)
FVB/NJ	MGP_FVBNJ_G0016785	protein coding gene	Chr1:187580283-187593042 (+)
LP/J	MGP_LPJ_G0016864	protein coding gene	Chr1:200086204-200097683 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016817	protein coding gene	Chr1:219498762-219511946 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017385	protein coding gene	Chr1:196269073-196282678 (+)
PWK/PhJ	MGP_PWKPhJ_G0016079	protein coding gene	Chr1:188754323-188766117 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015855	protein coding gene	Chr1:195278670-195294354 (+)
WSB/EiJ	MGP_WSBEiJ_G0016354	protein coding gene	Chr1:196518975-196532861 (+)

Human Ortholog

NEK2, NIMA related kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEK2, NIMA related kinase 2
Synonyms

HsPK21, NEK2A, NLK1, PPP1R111, RP67
Links

HGNC:7745

NCBI Gene ID: 4751

neXtProt AC: NX_P51955

UniProt: P51955
Chr Location

1q32.3; chr1:211658256-211675630 (-) GRCh38

MGI Vertebrate Homology

Nek2 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEK2
Gene Tree

Nek2

Diseases

1 with human NEK2 associations

				Human Disease	Mouse Models
				retinitis pigmentosa 67 IDs retinitis pigmentosa 67 DOID:0110359 ICD10CM:H35.5 OMIM:615565

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

54
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

29
cDNA Data

26
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nek2

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All Sequences

57
RefSeq

8
UniProt

6
CCDS

CCDS15623.1

Ensembl

ENSMUSG00000026622 (Evidence)
NCBI Gene

18005

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026622	Ensembl Gene Model \| MGI Sequence Detail	11607	C57BL/6J	± kb
transcript	ENSMUST00000027931	Ensembl \| MGI Sequence Detail	3227	Not Applicable
polypeptide	ENSMUSP00000027931	Ensembl \| MGI Sequence Detail	443	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011128 serine/threonine-protein kinase Nek2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 32

cDNA 26

Primer pair 6

Microarray probesets 5

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MGD-MRK-38404, MGI:2138121, MGI:2138656

Summaries

All 54

Developmental Gene Expression 13

Gene Ontology 11

Phenotypes 10
Earliest

J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
Latest

J:332091 Ding W, et al., Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2021 Mar;64(3):419-433

TSS for Nek2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10789	Chr1:191553588-191553601 (+)	39 bp
Tssr10790	Chr1:191553604-191553680 (+)	86 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23