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Slc4a3
Gene Detail
 Symbol
Name
ID
Slc4a3
solute carrier family 4 (anion exchanger), member 3
MGI:109350
Synonyms A930038D23Rik, Ae3
Feature Type protein coding gene
Genetic Map
Chromosome 1
39.16 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:75546266-75562172 bp, + strand
From VEGA annotation of GRCm38

  15907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a3

Human
homologs
Human Homolog SLC4A3, solute carrier family 4 (anion exchanger), member 3
NCBI Gene ID 6508
neXtProt AC  NX_P48751
Human Synonyms  AE3, SLC2C
Human Chr (Location)  2q36; chr2:219627570-219641980 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Spontaneous(1) Targeted(3)
Genomic Mutations involving Slc4a3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for one knock-out allele show inner retina defects including selective ERG b-wave depression, optic nerve and retinal vessel anomalies, sheathing of retinal vessels and late onset photoreceptor death. Homozygotes for another knock-out allele are more sensitive to seizure-inducing agents.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Slc4a3 interacts with 298 markers (Mir7-1, Mir7-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process anion transport, ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function anion:anion antiporter activity, anion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (266)    Tissues (118)    Images (29)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 266
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(3) cDNA(65)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019426 (Evidence)
Ensembl Gene ModelENSMUSG00000006576 (Evidence)
Entrez Gene20536 (Evidence)
UniGene5053
DFCITC1579742, TC1593935, TC1605126
DoTSDT.101722990, DT.102551920, DT.525445, DT.55146374
NIA Mouse Gene IndexU000478
Consensus CDS ProjectCCDS15080.1
International Mouse Knockout Project StatusSlc4a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019426 VEGA Gene Model | MGI Sequence Detail 15907 C57BL/6J ±  kb
transcript OTTMUST00000046376 VEGA | MGI Sequence Detail 7182 Not Applicable 
polypeptide OTTMUSP00000020937 VEGA | MGI Sequence Detail 1227 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(22) UniProt(11)
Polymorphisms RFLP(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018241 Anion exchange, conserved site
InterPro IPR001717 Anion exchange protein
InterPro IPR002979 Anion exchange protein 3
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
Protein Ontology PR:000015159 anion exchange protein 3
References (Earliest) J:16498 Kopito RR, et al., Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger. Cell. 1989 Dec 1;59(5):927-37
(Latest) J:198011 Eom T, et al., NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013;2:e00178
All references(46)
Other
accession IDs
MGD-MRK-1169, MGD-MRK-38395, MGI:1925074

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory