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Ctr9 Gene Detail
Summary
  • Symbol
    Ctr9
  • Name
    CTR9 homolog, Paf1/RNA polymerase II complex component
  • Synonyms
    Sh2bp1, Tsbp, Tsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:109345
    NCBI Gene: 22083
  • Gene Overview
    MyGene.info: CTR9
Location & Maps
more
  • Sequence Map
    Chr7:111028951-111056377 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27427 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CTR9, CTR9 homolog, Paf1/RNA polymerase II complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CTR9, CTR9 homolog, Paf1/RNA polymerase II complex component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p150, p150TSP, SH2BP1, TSBP
  • Links
    NCBI Gene ID: 9646
    neXtProt AC: NX_Q6PD62

  • Chr Location
    11p15.3; chr11:10750987-10779755 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40668
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CTR9
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ctr9
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023898 VEGA Gene Model | MGI Sequence Detail 27427 C57BL/6J ±  kb
transcript OTTMUST00000058384 VEGA | MGI Sequence Detail 4300 Not Applicable  
polypeptide OTTMUSP00000028282 VEGA | MGI Sequence Detail 1173 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    143 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006017 RNA polymerase-associated protein CTR9
  • InterPro Domains
    IPR031101 RNA polymerase-associated protein Ctr9
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013105 Tetratricopeptide repeat 2
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
less
  • All nucleic 145
    cDNA 145

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-33783, MGD-MRK-38390, MGI:2141821
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:32101 Malek SN, et al., p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. J Biol Chem. 1996 Mar 22;271(12):6952-62
  • Latest
    J:209381 Yoo HS, et al., Transcriptional regulator CTR9 inhibits Th17 differentiation via repression of IL-17 expression. J Immunol. 2014 Feb 15;192(4):1440-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory