Lad1 MGI Mouse Gene Detail - MGI:109343

Symbol

Lad1
Name

ladinin

Feature Type

protein coding gene
IDs

MGI:109343
NCBI Gene: 16763
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:135746336-135761079 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.30 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

470 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109343	protein coding gene	Chr1:135746336-135761080 (+)
129S1/SvImJ	ENSMUSG00200007923	protein coding gene	Chr1:133361188-133376001 (+)
A/J	ENSMUSG00195015235	protein coding gene	Chr1:132433601-132448418 (+)
AKR/J	ENSMUSG00220046941	protein coding gene	Chr1:132313346-132339090 (+)
BALB/cJ	ENSMUSG00180011056	protein coding gene	Chr1:132974184-132989016 (+)
C3H/HeJ	ENSMUSG00175006406	protein coding gene	Chr1:132677687-132692500 (+)
C57BL/6NJ	ENSMUSG00215011073	protein coding gene	Chr1:132676033-132690869 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014644	protein coding gene	Chr1:127427674-127442437 (+)
CAST/EiJ	ENSTCUG00005034568	protein coding gene	Chr1:131607032-131621943 (+)
CBA/J	ENSMUSG00210013871	protein coding gene	Chr1:132608027-132622837 (+)
DBA/2J	ENSMUSG00185028244	protein coding gene	Chr1:136984452-136999269 (+)
FVB/NJ	ENSMUSG00205002131	protein coding gene	Chr1:131943710-131958527 (+)
JF1/MsJ	ENSUMUG00000046407	protein coding gene	Chr1:136108326-136123229 (+)
LP/J	ENSMUSG00230038184	protein coding gene	Chr1:136508827-136523662 (+)
NOD/ShiLtJ	ENSMUSG00190002639	protein coding gene	Chr1:132622072-132636880 (+)
NZO/HlLtJ	ENSMUSG00225017637	protein coding gene	Chr1:140275748-140290579 (+)
PWK/PhJ	ENSLUMG00010025442	protein coding gene	Chr1:131733052-131748038 (+)
SPRET/EiJ	ENSMSPG00010011562	protein coding gene	Chr1:134535560-134550240 (+)
WSB/EiJ	ENSIUOG00005027899	protein coding gene	Chr1:132384875-132399617 (+)

Human Ortholog

LAD1, ladinin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAD1, ladinin 1
Synonyms

LadA
Links

HGNC:6472

NCBI Gene ID: 3898

UniProt: O00515
Chr Location

1q32.1; chr1:201380833-201399915 (-) GRCh38

MGI Vertebrate Homology

Lad1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAD1
Protein SuperFamily

Ladinin_1
Gene Tree

Lad1

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

5
Radiation induced

1
Genomic Mutations

3 involving Lad1
Incidental Mutations

CvDC
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

698
Tissues

16
cDNA Data

74
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lad1

ZFIN lad1

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS35723.1

Ensembl

ENSMUSG00000041782 (Evidence)
NCBI Gene

16763

			Length	Strain/Species	Flank
genomic	16763	NCBI Gene Model \| MGI Sequence Detail	14744	C57BL/6J	± kb
transcript	NM_133664	RefSeq \| MGI Sequence Detail	2992	C57BL/6
polypeptide	P57016	UniProt \| EBI \| MGI Sequence Detail	528	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009648 ladinin-1

(term hierarchy)
InterPro Domains

IPR017404 Ladinin 1

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All nucleic 76

Genomic 2

cDNA 74

Microarray probesets 3

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MGD-MRK-38388

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:284219 Wang B, et al., Macrophage beta2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis. Cell Rep. 2019 Feb 5;26(6):1614-1626.e5

TSS for Lad1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8990	Chr1:135746331-135746340 (+)	0 bp
Tssr8991	Chr1:135746399-135746410 (+)	69 bp
Tssr8992	Chr1:135746424-135746449 (+)	101 bp
Tssr8993	Chr1:135746450-135746461 (+)	120 bp
Tssr8994	Chr1:135746463-135746477 (+)	134 bp
Tssr8995	Chr1:135746504-135746511 (+)	172 bp
Tssr8996	Chr1:135746548-135746572 (+)	224 bp
Tssr8997	Chr1:135746580-135746587 (+)	248 bp
Tssr8998	Chr1:135746596-135746597 (+)	261 bp
Tssr8999	Chr1:135746609-135746638 (+)	288 bp
Tssr9000	Chr1:135746642-135746719 (+)	345 bp
Tssr9001	Chr1:135752778-135752801 (+)	6,454 bp
Tssr9002	Chr1:135754629-135754655 (+)	8,306 bp
Tssr9003	Chr1:135755010-135755041 (+)	8,690 bp
Tssr9004	Chr1:135755687-135755699 (+)	9,357 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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