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Eya3 Gene Detail
Summary
  • Symbol
    Eya3
  • Name
    EYA transcriptional coactivator and phosphatase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109339
    NCBI Gene: 14050
Location & Maps
more
  • Sequence Map
    Chr4:132638987-132724765 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 65.68 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    EYA3, EYA transcriptional coactivator and phosphatase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EYA3, EYA transcriptional coactivator and phosphatase 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2140
    neXtProt AC: NX_Q99504

  • Chr Location
    1p36; chr1:27970344-28088675 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    569
  • Chemically induced (other)
    2
  • Gene trapped
    563
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Eya3
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit abnormal heart function, decreased grip strength and increased exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009803 VEGA Gene Model | MGI Sequence Detail 85779 C57BL/6J ±  kb
transcript OTTMUST00000022722 VEGA | MGI Sequence Detail 5160 Not Applicable  
polypeptide OTTMUSP00000010370 VEGA | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    837 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 128
    cDNA 122
    Primer pair 4
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-38384, MGI:2140374
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:38379 Xu PX, et al., Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
  • Latest
    J:175997 Sano T, et al., Characterization of the threonine-phosphatase of mouse eyes absent 3. FEBS Lett. 2011 Sep 2;585(17):2714-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory